A new MAFia in cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-09

AUTHORS

Alain Eychène, Nathalie Rocques, Celio Pouponnot

ABSTRACT

Like JUN and FOS, the Maf transcription factors belong to the AP1 family. Besides their established role in human cancer--overexpression of the large Maf genes promotes the development of multiple myeloma--they can display tumour suppressor-like activity in specific cellular contexts, which is compatible with their physiological role in terminal differentiation. However, their oncogenic activity relies mostly on the acquisition of new biological functions relevant to cell transformation, the most striking characteristic of Maf oncoproteins being their ability to enhance pathological interactions between tumour cells and the stroma. More... »

PAGES

683-693

References to SciGraph publications

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  • Journal

    TITLE

    Nature Reviews Cancer

    ISSUE

    9

    VOLUME

    8

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc2460

    DOI

    http://dx.doi.org/10.1038/nrc2460

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1002355874

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19143053


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