Survivin, cancer networks and pathway-directed drug discovery View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-01

AUTHORS

Dario C Altieri

ABSTRACT

Although there is no shortage of potential targets for cancer therapeutics, we know of only a handful of molecules that are differentially expressed in cancer and intersect multiple pathways required for tumour maintenance. Survivin embodies these properties, and orchestrates integrated cellular networks that are essential for tumour cell proliferation and viability. Pursuing the nodal functions of survivin in cancer might lead to the development of global pathway inhibitors with unique therapeutic potential. More... »

PAGES

61-70

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc2293

    DOI

    http://dx.doi.org/10.1038/nrc2293

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020411420

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18075512


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