A microenvironmental model of carcinogenesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-01

AUTHORS

Robert A. Gatenby, Robert J. Gillies

ABSTRACT

We propose that carcinogenesis requires tumour populations to surmount six distinct microenvironmental proliferation barriers that arise in the adaptive landscapes of normal and premalignant populations growing from epithelial surfaces. Somatic evolution of invasive cancer can then be viewed as a sequence of phenotypical adaptations to these barriers. The genotypical and phenotypical heterogeneity of cancer populations is explained by an equivalence principle in which multiple strategies can successfully adapt to the same barrier. This model provides a theoretical framework in which the diverse cancer genotypes and phenotypes can be understood according to their roles as adaptive strategies to overcome specific microenvironmental growth constraints. More... »

PAGES

56-61

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrc2255

DOI

http://dx.doi.org/10.1038/nrc2255

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031460595

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18059462


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