Emerging roles of proteases in tumour suppression View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-10

AUTHORS

Carlos López-Otín, Lynn M. Matrisian

ABSTRACT

Proteases have long been associated with cancer progression because of their ability to degrade extracellular matrices, which facilitates invasion and metastasis. However, recent studies have shown that these enzymes target a diversity of substrates and favour all steps of tumour evolution. Unexpectedly, the post-trial studies have also revealed proteases with tumour-suppressive effects. These effects are associated with more than 30 different enzymes that belong to three distinct protease classes. What are the clinical implications of these findings? More... »

PAGES

800-808

References to SciGraph publications

  • 2003-08. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB in NATURE
  • 2004-11. The emerging roles of human tissue kallikreins in cancer in NATURE REVIEWS CANCER
  • 2005-12. ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation in ONCOGENE
  • 2007-11. Epigenetic identification of ADAMTS18 as a novel 16q23.1 tumor suppressor frequently silenced in esophageal, nasopharyngeal and multiple other carcinomas in ONCOGENE
  • 2006-06. Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis in NATURE CELL BIOLOGY
  • 2002-01. Low plasma levels of matrix metalloproteinase 9 permit increased tumor angiogenesis in ONCOGENE
  • 2000-05. Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN in NATURE MEDICINE
  • 2003-09. Inactivating mutations of CASPASE-7 gene in human cancers in ONCOGENE
  • 2002-12. Enzyme replacement and enhancement therapies: lessons from lysosomal disorders in NATURE REVIEWS GENETICS
  • 2006-10. Ubiquitin and ubiquitin-like proteins in cancer pathogenesis in NATURE REVIEWS CANCER
  • 2006-04. Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours in BRITISH JOURNAL OF CANCER
  • 2007-04. Cell biology: Autophagy and cancer in NATURE
  • 2002-07. Protease degradomics: A new challenge for proteomics in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2006-09. Targeting proteases: successes, failures and future prospects in NATURE REVIEWS DRUG DISCOVERY
  • 2005-02. Hypermethylation of the 5′ CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis in BRITISH JOURNAL OF CANCER
  • 2007-06. Lentiviral vector neutral endopeptidase gene transfer suppresses prostate cancer tumor growth in CANCER GENE THERAPY
  • 2001. Overexpression of matrix-metalloproteinase-9 in human breast cancer: a potential favourable indicator in node-negativeatients in BRITISH JOURNAL OF CANCER
  • 2004-02. The normal epithelial cell-specific 1 (NES1) gene, a candidate tumor suppressor gene on chromosome 19q13.3–4, is downregulated by hypermethylation in acute lymphoblastic leukemia in LEUKEMIA
  • 2006-04. Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively in ONCOGENE
  • 2002-09. Strategies for MMP inhibition in cancer: innovations for the post-trial era in NATURE REVIEWS CANCER
  • 2005-09. Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation in NATURE
  • 2002-04. Inactivating mutations of the caspase-10 gene in gastric cancer in ONCOGENE
  • 2004-07. FAPα, a surface peptidase expressed during wound healing, is a tumor suppressor in ONCOGENE
  • 2002-03. New functions for the matrix metalloproteinases in cancer progression in NATURE REVIEWS CANCER
  • 2000-06. Identification of the familial cylindromatosis tumour-suppressor gene in NATURE GENETICS
  • 2003-11. Loss of collagenase-2 confers increased skin tumor susceptibility to male mice in NATURE GENETICS
  • 2003-07. Human and mouse proteases: a comparative genomic approach in NATURE REVIEWS GENETICS
  • 2006-10. Cysteine cathepsins: multifunctional enzymes in cancer in NATURE REVIEWS CANCER
  • 2004-07. Somatic mutations of CASP3 gene in human cancers in HUMAN GENETICS
  • 2004-09. METH-2 silencing and promoter hypermethylation in NSCLC in BRITISH JOURNAL OF CANCER
  • 1946-04. Mechanism of the Proteolytic Activity of Malignant Tissue Cells in NATURE
  • 2006-03. Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy in NATURE REVIEWS CANCER
  • 2002-04. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization in NATURE
  • 2006-01. Potentiation of neuroblastoma metastasis by loss of caspase-8 in NATURE
  • 2007-01. Identification of a tumor suppressive critical region mapping to 3p14.2 in esophageal squamous cell carcinoma and studies of a candidate tumor suppressor gene, ADAMTS9 in ONCOGENE
  • 2006-03. Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC) in BRITISH JOURNAL OF CANCER
  • 2003. Matrix Metalloproteinases and Tumor Progression in NEW TRENDS IN CANCER FOR THE 21STCENTURY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc2228

    DOI

    http://dx.doi.org/10.1038/nrc2228

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17851543


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