Emerging roles of proteases in tumour suppression View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-10

AUTHORS

Carlos López-Otín, Lynn M. Matrisian

ABSTRACT

Proteases have long been associated with cancer progression because of their ability to degrade extracellular matrices, which facilitates invasion and metastasis. However, recent studies have shown that these enzymes target a diversity of substrates and favour all steps of tumour evolution. Unexpectedly, the post-trial studies have also revealed proteases with tumour-suppressive effects. These effects are associated with more than 30 different enzymes that belong to three distinct protease classes. What are the clinical implications of these findings? More... »

PAGES

800-808

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc2228

    DOI

    http://dx.doi.org/10.1038/nrc2228

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17851543


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