Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-10

AUTHORS

Javier A. Menendez, Ruth Lupu

ABSTRACT

There is a renewed interest in the ultimate role of fatty acid synthase (FASN)--a key lipogenic enzyme catalysing the terminal steps in the de novo biogenesis of fatty acids--in cancer pathogenesis. Tumour-associated FASN, by conferring growth and survival advantages rather than functioning as an anabolic energy-storage pathway, appears to necessarily accompany the natural history of most human cancers. A recent identification of cross-talk between FASN and well-established cancer-controlling networks begins to delineate the oncogenic nature of FASN-driven lipogenesis. FASN, a nearly-universal druggable target in many human carcinomas and their precursor lesions, offers new therapeutic opportunities for metabolically treating and preventing cancer. More... »

PAGES

763-777

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  • Journal

    TITLE

    Nature Reviews Cancer

    ISSUE

    10

    VOLUME

    7

    Clinical Trials linked to this publication

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc2222

    DOI

    http://dx.doi.org/10.1038/nrc2222

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024304300

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17882277


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    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrc2222'

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