MicroRNA signatures in human cancers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-11

AUTHORS

George A. Calin, Carlo M. Croce

ABSTRACT

MicroRNA (miRNA) alterations are involved in the initiation and progression of human cancer. The causes of the widespread differential expression of miRNA genes in malignant compared with normal cells can be explained by the location of these genes in cancer-associated genomic regions, by epigenetic mechanisms and by alterations in the miRNA processing machinery. MiRNA-expression profiling of human tumours has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment. In addition, profiling has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein-coding genes involved in cancer. More... »

PAGES

857-866

References to SciGraph publications

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  • Journal

    TITLE

    Nature Reviews Cancer

    ISSUE

    11

    VOLUME

    6

    Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc1997

    DOI

    http://dx.doi.org/10.1038/nrc1997

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044012298

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17060945


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