Targeting polo-like kinase 1 for cancer therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-04

AUTHORS

Klaus Strebhardt, Axel Ullrich

ABSTRACT

Human polo-like kinase 1 (PLK1) is essential during mitosis and in the maintenance of genomic stability. PLK1 is overexpressed in human tumours and has prognostic potential in cancer, indicating its involvement in carcinogenesis and its potential as a therapeutic target. The use of different PLK1 inhibitors has increased our knowledge of mitotic regulation and allowed us to assess their ability to suppress tumour growth in vivo. We address the structural features of the kinase domain and the unique polo-box domain of PLK1 that are most suited for drug development and discuss our current understanding of the therapeutic potential of PLK1. More... »

PAGES

321-330

References to SciGraph publications

  • 1994-02. Hot lips and phosphorylation of protein kinases in NATURE
  • 2002-02. Scytonemin-a marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases in INFLAMMATION RESEARCH
  • 2000-09. Polo-like kinase-1 is a target of the DNA damage checkpoint in NATURE CELL BIOLOGY
  • 2002-05. Downregulation of human polo-like kinase activity by antisense oligonucleotides induces growth inhibition in cancer cells in ONCOGENE
  • 2004-06. Polo-like kinases and the orchestration of cell division in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2003-06. Expression profiling reveals off-target gene regulation by RNAi in NATURE BIOTECHNOLOGY
  • 2004-08. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas in ONCOGENE
  • 2003-02. Active cyclin B1–Cdk1 first appears on centrosomes in prophase in NATURE CELL BIOLOGY
  • 2004-12. Strategies to overcome resistance to targeted protein kinase inhibitors in NATURE REVIEWS DRUG DISCOVERY
  • 2005-01. Regulation of cell cycle checkpoints by polo-like kinases in ONCOGENE
  • 1997-02. Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer in ONCOGENE
  • 2005-01. Polo-like kinases and oncogenesis in ONCOGENE
  • 2002-11. Cooperative phosphorylation including the activity of polo-like kinase 1 regulates the subcellular localization of cyclin B1 in ONCOGENE
  • 2004-01. Polo-like kinase 1 overexpression is an early event in the progression of papillary carcinoma in BRITISH JOURNAL OF CANCER
  • 2004-12. Aurora-kinase inhibitors as anticancer agents in NATURE REVIEWS CANCER
  • 2005-01. The anaphase-promoting complex: a key factor in the regulation of cell cycle in ONCOGENE
  • 2005-01. Anaphase-promoting complex-dependent proteolysis of cell cycle regulators and genomic instability of cancer cells in ONCOGENE
  • 2001-03. Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase in NATURE
  • 2004-03. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo in NATURE MEDICINE
  • 2001-10. Comparative Expression of the Mitotic Regulators SAK and PLK in Colorectal Cancer in ANNALS OF SURGICAL ONCOLOGY
  • 2005-01. Structure and function of Polo-like kinases in ONCOGENE
  • 1998-12. Mouse polo-like kinase 1 associates with the acentriolar spindle poles, meiotic chromosomes and spindle midzone during oocyte maturation in CHROMOSOMA
  • 1998-12. GFP tagging reveals human Polo-like kinase 1 at the kinetochore/centromere region of mitotic chromosomes in CHROMOSOMA
  • 2005-04. Getting in and out of mitosis with Polo-like kinase-1 in ONCOGENE
  • 1993-06. A conserved mitotic kinase active at late anaphase—telophase in syncytial Drosophila embryos in NATURE
  • 2005-04. Polo-like kinase isoforms in breast cancer: expression patterns and prognostic implications in VIRCHOWS ARCHIV
  • 2000-10. Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages in ONCOGENE
  • 2001-05. Increased Human Polo-Like Kinase-1 Expression in Gliomas in JOURNAL OF NEURO-ONCOLOGY
  • 2002-12. Crystal structure of an activated Akt/Protein Kinase B ternary complex with GSK3-peptide and AMP-PNP in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2000-11. Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines in NATURE CELL BIOLOGY
  • Journal

    TITLE

    Nature Reviews Cancer

    ISSUE

    4

    VOLUME

    6

    Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc1841

    DOI

    http://dx.doi.org/10.1038/nrc1841

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035809252

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16557283


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