Oncomirs — microRNAs with a role in cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-04

AUTHORS

Aurora Esquela-Kerscher, Frank J Slack

ABSTRACT

MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators. They regulate diverse biological processes, and bioinformatic data indicates that each miRNA can control hundreds of gene targets, underscoring the potential influence of miRNAs on almost every genetic pathway. Recent evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes. miRNAs have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer. More... »

PAGES

259-269

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  • Journal

    TITLE

    Nature Reviews Cancer

    ISSUE

    4

    VOLUME

    6

    Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc1840

    DOI

    http://dx.doi.org/10.1038/nrc1840

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1030226923

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16557279


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