Detection and interpretation of altered methylation patterns in cancer cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-03

AUTHORS

Toshikazu Ushijima

ABSTRACT

Epigenetic alterations, such as abnormal DNA-methylation patterns, are associated with many human tumour types. New techniques have been developed to perform genome-wide screening for alterations in DNA-methylation patterns, not only to identify tumour-suppressor genes, but also to find patterns that can be used in diagnosis and prognosis. However, interpretation of differential methylation has proven difficult because the significance of methylation alterations depends on the genomic region, and functions of CpG islands at specific sites have not been fully clarified. What techniques can be used to identify new tumour suppressors and diagnostic markers? More... »

PAGES

223-231

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc1571

    DOI

    http://dx.doi.org/10.1038/nrc1571

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031272878

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15719030


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