Galectins as modulators of tumour progression View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-01

AUTHORS

Fu-Tong Liu, Gabriel A. Rabinovich

ABSTRACT

Galectins are a family of animal lectins with diverse biological activities. They function both extracellularly, by interacting with cell-surface and extracellular matrix glycoproteins and glycolipids, and intracellularly, by interacting with cytoplasmic and nuclear proteins to modulate signalling pathways. Current research indicates that galectins have important roles in cancer; they contribute to neoplastic transformation, tumour cell survival, angiogenesis and tumour metastasis. They can modulate the immune and inflammatory responses and might have a key role helping tumours to escape immune surveillance. How do the different members of the Galectin family contribute to these diverse aspects of tumour biology? More... »

PAGES

29-41

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc1527

    DOI

    http://dx.doi.org/10.1038/nrc1527

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1027571841

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15630413


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