Why do cancers have high aerobic glycolysis? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-11

AUTHORS

Robert A Gatenby, Robert J Gillies

ABSTRACT

If carcinogenesis occurs by somatic evolution, then common components of the cancer phenotype result from active selection and must, therefore, confer a significant growth advantage. A near-universal property of primary and metastatic cancers is upregulation of glycolysis, resulting in increased glucose consumption, which can be observed with clinical tumour imaging. We propose that persistent metabolism of glucose to lactate even in aerobic conditions is an adaptation to intermittent hypoxia in pre-malignant lesions. However, upregulation of glycolysis leads to microenvironmental acidosis requiring evolution to phenotypes resistant to acid-induced cell toxicity. Subsequent cell populations with upregulated glycolysis and acid resistance have a powerful growth advantage, which promotes unconstrained proliferation and invasion. More... »

PAGES

891-899

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc1478

    DOI

    http://dx.doi.org/10.1038/nrc1478

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032257073

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15516961


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