Friends or foes — bipolar effects of the tumour stroma in cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-11

AUTHORS

Margareta M. Mueller, Norbert E. Fusenig

ABSTRACT

The restricted view of tumour progression as a multistep process defined by the accumulation of mutations in cancer cells has largely ignored the substantial contribution of the tumour microenvironment to malignancy. Even though the seed and soil hypothesis of Paget dates to 1889, it has been less than two decades since researchers have included the tumour microenvironment in their analyses of tumour progression. What have we recently learned from studying tumour-stroma interactions, and will this help to define new targets for therapy? More... »

PAGES

839-849

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc1477

    DOI

    http://dx.doi.org/10.1038/nrc1477

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15516957


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