The anti-angiogenic basis of metronomic chemotherapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-06

AUTHORS

Robert S Kerbel, Barton A Kamen

ABSTRACT

In addition to proliferating cancer cells and various types of normal cells, such as those of the bone marrow, conventional cytotoxic chemotherapeutics affect the endothelium of the growing tumour vasculature. The anti-angiogenic efficacy of chemotherapy seems to be optimized by administering comparatively low doses of drug on a frequent or continuous schedule, with no extended interruptions — sometimes referred to as 'metronomic' chemotherapy. In addition to reduced acute toxicity, the efficacy of metronomic chemotherapy seems to increase when administered in combination with specific anti-angiogenic drugs. Gaining better insight into the mechanisms of these effects could lessen or even eliminate the empiricism used to determine the optimal dose and schedule for metronomic chemotherapy regimens. More... »

PAGES

423-436

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc1369

    DOI

    http://dx.doi.org/10.1038/nrc1369

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019159796

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15170445


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