A census of human cancer genes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-03

AUTHORS

P. Andrew Futreal, Lachlan Coin, Mhairi Marshall, Thomas Down, Timothy Hubbard, Richard Wooster, Nazneen Rahman, Michael R. Stratton

ABSTRACT

Key PointsWe have conducted a census from the literature of genes that are mutated and causally implicated in cancer development ('cancer genes').So far, 291 cancer genes have been reported, more than 1% of all the genes in the human genome.90% of cancer genes show somatic mutations in cancer, 20% show germline mutations and 10% show both.The most common mutation class among the known cancer genes is a chromosomal translocation that creates a chimeric gene or apposes a gene to the regulatory elements of another gene.Many more cancer genes have been found in leukaemias, lymphomas and sarcomas than in other types of cancer, despite the fact that they represent only 10% of human cancer. These genes are usually altered by chromosomal translocation.The most common domain that is encoded by cancer genes is the protein kinase. Several domains that are involved in DNA binding and transcriptional regulation are common in proteins that are encoded by cancer genes. More... »

PAGES

177-183

Journal

TITLE

Nature Reviews Cancer

ISSUE

3

VOLUME

4

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc1299

    DOI

    http://dx.doi.org/10.1038/nrc1299

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022731034

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/14993899


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