A census of human cancer genes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-03

AUTHORS

P. Andrew Futreal, Lachlan Coin, Mhairi Marshall, Thomas Down, Timothy Hubbard, Richard Wooster, Nazneen Rahman, Michael R. Stratton

ABSTRACT

A central aim of cancer research has been to identify the mutated genes that are causally implicated in oncogenesis ('cancer genes'). After two decades of searching, how many have been identified and how do they compare to the complete gene set that has been revealed by the human genome sequence? We have conducted a 'census' of cancer genes that indicates that mutations in more than 1% of genes contribute to human cancer. The census illustrates striking features in the types of sequence alteration, cancer classes in which oncogenic mutations have been identified and protein domains that are encoded by cancer genes. More... »

PAGES

177-183

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nrc1299

DOI

http://dx.doi.org/10.1038/nrc1299

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14993899


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