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AUTHORS ABSTRACTKey PointsDiet is thought to be one of the most important contributing factors to cancer risk, but is linked to metabolic and genetic factors.The European Prospective Investigation into Cancer and Nutrition (EPIC) — a study of over 500,000 people in 10 European countries — was devised to investigate the relationship between diet, metabolic and genetic factors, and cancer.In the EPIC study, food consumption has been measured by country-specific questionnaires that were designed to capture local dietary habits and to provide high compliance. At the time of enrolment, weight, height, lifestyle and personal history data were also collected, along with biological samples including plasma, serum, leukocytes and erythrocytes, from approximately 400,000 individuals, which have been stored in liquid nitrogen.Over 9 million samples have been stored, making the EPIC centres, collectively, the largest biorepository in the world that is available for genetic, metabolic, biochemical and epidemiological data.Subsets of the EPIC study, called 'The Eurogast project' and 'Genair', have been initiated to investigate correlations between tumour-associated genetic mutations, polymorphisms, diet and cancer.EPIC study data are already available on the associations between dietary fibre intake and colorectal cancer, and between fat intake and breast cancer.Large, prospective studies are the best way to study the interaction between diet and cancer.Information on lifestyle and environmental exposure, especially of diet and biomarkers, can only be accurately determined by studying large populations over prolonged periods of time. More... »
PAGES206-215
http://scigraph.springernature.com/pub.10.1038/nrc1298
DOIhttp://dx.doi.org/10.1038/nrc1298
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/14993902
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