The STATs of cancer — new molecular targets come of age View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-02

AUTHORS

Hua Yu, Richard Jove

ABSTRACT

Key PointsSignal transducer and activator of transcription (STAT)-family proteins are latent cytoplasmic transcription factors that convey signals from cytokine and growth-factor receptors to the nucleus.STAT proteins, particularly STAT3 and the STAT5 proteins, are frequently overactivated in a variety of human solid tumours and blood malignancies.Continuous deregulation of nuclear gene expression by persistent STAT3 and STAT5 signalling promotes the growth and survival of tumour cells, thereby contributing to malignancy.Persistent STAT3 signalling in tumour cells induces tumour angiogenesis and suppresses anti-tumour immune responses, further enhancing tumour progression.Tumour cells that become dependent on persistent STAT3 signalling are more sensitive to STAT3 inhibitors than normal cells, providing a therapeutic window based on transient or partial inhibition of STAT3.Proof-of-concept studies in cell-culture and animal models have validated STAT3 and STAT5 proteins as promising molecular targets for novel cancer therapies, including small-molecule inhibitors of STAT signalling. More... »

PAGES

97-105

References to SciGraph publications

  • 2003-09-17. Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells in BMC CANCER
  • 2003. STAT Signaling in Cancer: Insights into Pathogenesis and Treatment Strategies in SIGNAL TRANSDUCTION IN CANCER
  • 2002-04. Spinning molecular immunology into successful immunotherapy in NATURE REVIEWS IMMUNOLOGY
  • 2001-04-26. IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity in NATURE
  • 2000-11-20. Role of Src expression and activation in human cancer in ONCOGENE
  • 2000-06. Compromised HOXA5 function can limit p53 expression in human breast tumours in NATURE
  • 2000-05-25. Modulation of STAT signaling by STAT-interacting proteins in ONCOGENE
  • 2002-01-10. Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis in ONCOGENE
  • 2000-05-25. STATs in oncogenesis in ONCOGENE
  • 2002-03-21. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis in ONCOGENE
  • 2003-12-21. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells in NATURE MEDICINE
  • 2001-05-03. Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells in ONCOGENE
  • 1992-10. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo in NATURE
  • 2001-05-01. Oncogenic kinase signalling in NATURE
  • 2002-10-09. Roles of activated Src and Stat3 signaling in melanoma tumor cell growth in ONCOGENE
  • 2002-10. Transcription factors as targets for cancer therapy in NATURE REVIEWS CANCER
  • 2003-01-22. Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis in ONCOGENE
  • 2000-05-25. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors in ONCOGENE
  • 2000-05-25. IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled in ONCOGENE
  • 1994-02. Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant in NATURE
  • 2000-11. Surfing the p53 network in NATURE
  • 1999-05-13. Mechanisms of apoptosis by c-Myc in ONCOGENE
  • 2003-03-11. Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway in ONCOGENE
  • 2000-05-25. The role of STATs in transcriptional control and their impact on cellular function in ONCOGENE
  • 2000-12-27. STAT proteins: novel molecular targets for cancer drug discovery in ONCOGENE
  • 2001-05. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity in NATURE GENETICS
  • 2003-07-02. Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells in ONCOGENE
  • 2000-11-16. Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling in ONCOGENE
  • 2002-02-07. Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death in ONCOGENE
  • 1993-10. The pathway to signal achievement in NATURE
  • 1996-10. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells in NATURE MEDICINE
  • 2002-09-01. STATs: transcriptional control and biological impact in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2000-05-25. STAT signaling in head and neck cancer in ONCOGENE
  • 2000-05-25. JAK-STAT signaling activated by Abl oncogenes in ONCOGENE
  • 2000-05-25. STAT signaling in the pathogenesis and treatment of leukemias in ONCOGENE
  • 2002-12-12. Inhibition of Bcr–Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells in ONCOGENE
  • 2000-05-25. Roles of STAT3 defined by tissue-specific gene targeting in ONCOGENE
  • 2002-07-01. The phosphatidylinositol 3-Kinase–AKT pathway in human cancer in NATURE REVIEWS CANCER
  • 2003-12. Targeting HIF-1 for cancer therapy in NATURE REVIEWS CANCER
  • Journal

    TITLE

    Nature Reviews Cancer

    ISSUE

    2

    VOLUME

    4

    Related Patents

  • Indirubin Derivatives And Uses Thereof In Treating Chronic Myelogenous Leukemia
  • Compounds That Suppress Cancer Cells And Exhibit Antitumor Activity
  • Preparation And Uses Of 1,2,4-Triazolo [1,5a] Pyridine Derivatives
  • Stat3 Pathway Inhibitors And Cancer Stem Cell Inhibitors
  • Compositions And Methods For Cancer Treatment
  • Stat3 Inhibitors
  • Fused Quinonic Compounds
  • Platinum Iv Complex Inhibitor
  • Stat3 Inhibitor
  • Stat3 Inhibitor Having Anti-Cancer Activity And Methods
  • Stat3 Inhibitors
  • Compositions And Methods For Cancer Treatment
  • Use Of Phenyl Phosphates And Their Prodrugs As Drugs In Cancer Therapy
  • Gla Domains As Targeting Agents
  • Indirubin Derivatives, And Uses Thereof
  • Methods Of Predicting Responsiveness To Chemotherapeutic Agents And Selecting Treatments
  • Methods For Inhibiting Stat3 Signaling In Immune Cells
  • 6-Aryl-7-Substituted-3-(1h-Pyrazol-5-Yl)-7h-[1,2,4]Triazolo[3,4-B][1,3,4]Thiadiazines As Inhibitors Of The Stat3 Pathway With Anti-Proliferative Activity
  • Methods And Compositions For Prevention Of Allergic Reaction
  • Platinum Compounds That Inhibit Constitutive Stat3 Signaling And Induce Cell Cycle Arrest And Apoptosis Of Malignant Cells
  • Stat3 Inhibitor
  • 2-Acetylnaphtho[2,3-B]Furan -4,9-Dione For Use On Treating Cancer
  • Rna Aptamers Against Baff-R As Cell-Type Specific Delivery Agents And Methods For Their Use
  • Salicylic Acid Derivatives, Pharmaceutically Acceptable Salt Thereof, Composition Thereof And Method Of Use Thereof
  • Methods For Predicting Treatment Response Based On The Expression Profiles Of Protein And Transcription Biomarkers
  • Humanized Lewis-Y Specific Antibody-Based Delivery Of Dicer Substrate Sirna (D-Sirna) Against Stat3
  • Platinum Compounds That Inhibit Constitutive Stat3 Signaling And Induce Cell Cycle Arrest And Apoptosis Of Malignant Cells
  • Substituted 2-Hydroxy-4-(2-(Phenylsulfonamido)Acetamido)Benzoic Acid Analogs As Inhibitors Of Stat Protein
  • Naphthofuran Derivatives, Preparation, And Methods Of Use Thereof
  • Biomarkers For Prognosis Of Lung Cancer
  • Stabilized Stat3 Decoy Oligonucleotides And Uses Therefor
  • Preparation And Uses Of 1,2,4-Triazolo [1,5a] Pyridine Derivatives
  • Methods For Treating Cancer
  • 6-Aryl-7-Substituted-3-(1h-Pyrazol-5-Yl)-7h-[1,2,4]Triazolo[3,4-B][1,3,4]Thiadiazines As Inhibitors Of The Stat3 Pathway With Anti-Proliferative Activity
  • Methods And Compositions For Treatment Of Fibrosis
  • Inhibitors Of Stat3 And Uses Thereof
  • Macrocyclic Compounds As Alk, Fak And Jak2 Inhibitors
  • New Salicylic Acid Derivatives, Pharmaceutically Acceptable Salt Thereof, Composition Thereof And Method Of Use Thereof
  • Substituted 2-Hydroxy-4-(2-(Phenylsulfonamido)Acetamido)Benzoic Acid Analogs As Inhibitors Of Stat Proteins
  • Rna Aptamers Against Baff-R As Cell-Type Specific Delivery Agents And Methods For Their Use
  • Substituted 2-Hydroxy-4-(2-(Phenylsulfonamido)Acetamido)Benzoic Acid Analogs As Inhibitors Of Stat Protein
  • Gla Domains As Targeting Agents
  • Stat3 Protein Degraders
  • Fused Quinonic Compounds
  • Salicylic Acid Derivatives, Pharmaceutically Acceptable Salt Thereof, Composition Thereof And Method Of Use Thereof
  • Novel Stat3 Inhibitors
  • Drug Composition Cytotoxic For Pancreatic Cancer Cells
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc1275

    DOI

    http://dx.doi.org/10.1038/nrc1275

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031068002

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/14964307


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Apoptosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Division", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA-Binding Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Milk Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neovascularization, Pathologic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "STAT2 Transcription Factor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "STAT5 Transcription Factor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Trans-Activators", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Immunology Program and Department of Interdisciplinary Oncology, University of South Florida College of Medicine, 33612, Tampa, Florida, USA", 
              "id": "http://www.grid.ac/institutes/grid.170693.a", 
              "name": [
                "Immunology Program and Department of Interdisciplinary Oncology, University of South Florida College of Medicine, 33612, Tampa, Florida, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yu", 
            "givenName": "Hua", 
            "id": "sg:person.01322016332.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322016332.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "H. Lee Moffitt Cancer Center and Research Institute and Department of Interdisciplinary Oncology, Molecular Oncology Program, University of South Florida College of Medicine, 33612, Tampa, Florida, USA", 
              "id": "http://www.grid.ac/institutes/grid.170693.a", 
              "name": [
                "H. Lee Moffitt Cancer Center and Research Institute and Department of Interdisciplinary Oncology, Molecular Oncology Program, University of South Florida College of Medicine, 33612, Tampa, Florida, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jove", 
            "givenName": "Richard", 
            "id": "sg:person.0613555447.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613555447.67"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/sj.onc.1206479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041803871", 
              "https://doi.org/10.1038/sj.onc.1206479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/367576a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016282476", 
              "https://doi.org/10.1038/367576a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203912", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036305391", 
              "https://doi.org/10.1038/sj.onc.1203912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35077225", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037528958", 
              "https://doi.org/10.1038/35077225"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc906", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046543214", 
              "https://doi.org/10.1038/nrc906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029504869", 
              "https://doi.org/10.1038/sj.onc.1203947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203478", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002051407", 
              "https://doi.org/10.1038/sj.onc.1203478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1096-1096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021940849", 
              "https://doi.org/10.1038/nm1096-1096"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008616882", 
              "https://doi.org/10.1038/sj.onc.1206226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041380684", 
              "https://doi.org/10.1038/sj.onc.1206122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203484", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005311964", 
              "https://doi.org/10.1038/sj.onc.1203484"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm976", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049736419", 
              "https://doi.org/10.1038/nm976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015007460", 
              "https://doi.org/10.1038/sj.onc.1204086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0501-29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003632653", 
              "https://doi.org/10.1038/ng0501-29"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-3-23", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016396934", 
              "https://doi.org/10.1186/1471-2407-3-23"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc839", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014023118", 
              "https://doi.org/10.1038/nrc839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001510184", 
              "https://doi.org/10.1038/sj.onc.1206028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205152", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042163942", 
              "https://doi.org/10.1038/sj.onc.1205152"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034382167", 
              "https://doi.org/10.1038/nrc1187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/365781a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020168730", 
              "https://doi.org/10.1038/365781a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027056444", 
              "https://doi.org/10.1038/sj.onc.1203486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203594", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019935517", 
              "https://doi.org/10.1038/sj.onc.1203594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203527", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007050008", 
              "https://doi.org/10.1038/sj.onc.1203527"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203476", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009697050", 
              "https://doi.org/10.1038/sj.onc.1203476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35016125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045061122", 
              "https://doi.org/10.1038/35016125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/0-306-48158-8_11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021261427", 
              "https://doi.org/10.1007/0-306-48158-8_11"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35074122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001419011", 
              "https://doi.org/10.1038/35074122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1202727", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016362345", 
              "https://doi.org/10.1038/sj.onc.1202727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205260", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006935562", 
              "https://doi.org/10.1038/sj.onc.1205260"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203483", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005181530", 
              "https://doi.org/10.1038/sj.onc.1203483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203522", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019679218", 
              "https://doi.org/10.1038/sj.onc.1203522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/359845a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021927273", 
              "https://doi.org/10.1038/359845a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003489702", 
              "https://doi.org/10.1038/sj.onc.1204349"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023491583", 
              "https://doi.org/10.1038/sj.onc.1205004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri774", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045044815", 
              "https://doi.org/10.1038/nri774"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203551", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026415083", 
              "https://doi.org/10.1038/sj.onc.1203551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205859", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014860210", 
              "https://doi.org/10.1038/sj.onc.1205859"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35042675", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023763406", 
              "https://doi.org/10.1038/35042675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045111933", 
              "https://doi.org/10.1038/nrm909"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2004-02", 
        "datePublishedReg": "2004-02-01", 
        "description": "Key PointsSignal transducer and activator of transcription (STAT)-family proteins are latent cytoplasmic transcription factors that convey signals from cytokine and growth-factor receptors to the nucleus.STAT proteins, particularly STAT3 and the STAT5 proteins, are frequently overactivated in a variety of human solid tumours and blood malignancies.Continuous deregulation of nuclear gene expression by persistent STAT3 and STAT5 signalling promotes the growth and survival of tumour cells, thereby contributing to malignancy.Persistent STAT3 signalling in tumour cells induces tumour angiogenesis and suppresses anti-tumour immune responses, further enhancing tumour progression.Tumour cells that become dependent on persistent STAT3 signalling are more sensitive to STAT3 inhibitors than normal cells, providing a therapeutic window based on transient or partial inhibition of STAT3.Proof-of-concept studies in cell-culture and animal models have validated STAT3 and STAT5 proteins as promising molecular targets for novel cancer therapies, including small-molecule inhibitors of STAT signalling.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/nrc1275", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1029716", 
            "issn": [
              "1474-175X", 
              "1474-1768"
            ], 
            "name": "Nature Reviews Cancer", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "4"
          }
        ], 
        "keywords": [
          "persistent STAT3", 
          "latent cytoplasmic transcription factors", 
          "nuclear gene expression", 
          "cytoplasmic transcription factors", 
          "activator of transcription", 
          "molecular targets", 
          "small molecule inhibitors", 
          "family proteins", 
          "STAT5 proteins", 
          "transcription factors", 
          "growth factor receptor", 
          "novel cancer therapies", 
          "gene expression", 
          "STAT3 inhibitor", 
          "anti-tumor immune response", 
          "tumor cells", 
          "STAT3", 
          "protein", 
          "normal cells", 
          "STAT5", 
          "human solid tumors", 
          "tumor progression", 
          "tumor angiogenesis", 
          "cells", 
          "immune response", 
          "therapeutic window", 
          "partial inhibition", 
          "animal models", 
          "solid tumors", 
          "blood malignancies", 
          "cancer therapy", 
          "STATs", 
          "transcription", 
          "inhibitors", 
          "malignancy", 
          "STAT", 
          "target", 
          "activator", 
          "concept study", 
          "deregulation", 
          "expression", 
          "angiogenesis", 
          "receptors", 
          "cytokines", 
          "therapy", 
          "tumors", 
          "inhibition", 
          "growth", 
          "nucleus", 
          "progression", 
          "survival", 
          "age", 
          "transducer", 
          "variety", 
          "response", 
          "signals", 
          "factors", 
          "study", 
          "window", 
          "model", 
          "continuous deregulation"
        ], 
        "name": "The STATs of cancer \u2014 new molecular targets come of age", 
        "pagination": "97-105", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1031068002"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nrc1275"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "14964307"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nrc1275", 
          "https://app.dimensions.ai/details/publication/pub.1031068002"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T16:55", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_393.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/nrc1275"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrc1275'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrc1275'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrc1275'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrc1275'


     

    This table displays all metadata directly associated to this object as RDF triples.

    331 TRIPLES      21 PREDICATES      137 URIs      90 LITERALS      18 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nrc1275 schema:about N14b7fcac954e4ea2a0f0ec0503c28dab
    2 N2d2f6bbc44444b44a00252618dd0cc90
    3 N63b95754c163457ab83b165579f06a27
    4 N68e179f3e45b4582a4cb385066a1b9a4
    5 N96c58fbb2c224c26872656cb6b5e00fa
    6 N9bdb9ec2f4ee4804b40ff469e8024d10
    7 Naf00ee38640d435e9e4a30fa381d0e6c
    8 Nb0751ad209a14eefa68ebc6a2ec70ddc
    9 Nf7a76d1931ba4031a9313547e079f103
    10 Nfd6f2ce6531146ebaafb9db922377c25
    11 Nffda4b06ba294dbebab5cec0b58940b1
    12 anzsrc-for:11
    13 anzsrc-for:1112
    14 schema:author Nc3c62fcf291a434a9fff5cdab6146b4f
    15 schema:citation sg:pub.10.1007/0-306-48158-8_11
    16 sg:pub.10.1038/35016125
    17 sg:pub.10.1038/35042675
    18 sg:pub.10.1038/35074122
    19 sg:pub.10.1038/35077225
    20 sg:pub.10.1038/359845a0
    21 sg:pub.10.1038/365781a0
    22 sg:pub.10.1038/367576a0
    23 sg:pub.10.1038/ng0501-29
    24 sg:pub.10.1038/nm1096-1096
    25 sg:pub.10.1038/nm976
    26 sg:pub.10.1038/nrc1187
    27 sg:pub.10.1038/nrc839
    28 sg:pub.10.1038/nrc906
    29 sg:pub.10.1038/nri774
    30 sg:pub.10.1038/nrm909
    31 sg:pub.10.1038/sj.onc.1202727
    32 sg:pub.10.1038/sj.onc.1203476
    33 sg:pub.10.1038/sj.onc.1203478
    34 sg:pub.10.1038/sj.onc.1203483
    35 sg:pub.10.1038/sj.onc.1203484
    36 sg:pub.10.1038/sj.onc.1203486
    37 sg:pub.10.1038/sj.onc.1203522
    38 sg:pub.10.1038/sj.onc.1203527
    39 sg:pub.10.1038/sj.onc.1203551
    40 sg:pub.10.1038/sj.onc.1203594
    41 sg:pub.10.1038/sj.onc.1203912
    42 sg:pub.10.1038/sj.onc.1203947
    43 sg:pub.10.1038/sj.onc.1204086
    44 sg:pub.10.1038/sj.onc.1204349
    45 sg:pub.10.1038/sj.onc.1205004
    46 sg:pub.10.1038/sj.onc.1205152
    47 sg:pub.10.1038/sj.onc.1205260
    48 sg:pub.10.1038/sj.onc.1205859
    49 sg:pub.10.1038/sj.onc.1206028
    50 sg:pub.10.1038/sj.onc.1206122
    51 sg:pub.10.1038/sj.onc.1206226
    52 sg:pub.10.1038/sj.onc.1206479
    53 sg:pub.10.1186/1471-2407-3-23
    54 schema:datePublished 2004-02
    55 schema:datePublishedReg 2004-02-01
    56 schema:description Key PointsSignal transducer and activator of transcription (STAT)-family proteins are latent cytoplasmic transcription factors that convey signals from cytokine and growth-factor receptors to the nucleus.STAT proteins, particularly STAT3 and the STAT5 proteins, are frequently overactivated in a variety of human solid tumours and blood malignancies.Continuous deregulation of nuclear gene expression by persistent STAT3 and STAT5 signalling promotes the growth and survival of tumour cells, thereby contributing to malignancy.Persistent STAT3 signalling in tumour cells induces tumour angiogenesis and suppresses anti-tumour immune responses, further enhancing tumour progression.Tumour cells that become dependent on persistent STAT3 signalling are more sensitive to STAT3 inhibitors than normal cells, providing a therapeutic window based on transient or partial inhibition of STAT3.Proof-of-concept studies in cell-culture and animal models have validated STAT3 and STAT5 proteins as promising molecular targets for novel cancer therapies, including small-molecule inhibitors of STAT signalling.
    57 schema:genre article
    58 schema:isAccessibleForFree false
    59 schema:isPartOf N130ba57a07d8429abdf309bd6a3d4ef2
    60 N5471bf0c8e49438dbb0ccbbad88f2889
    61 sg:journal.1029716
    62 schema:keywords STAT
    63 STAT3
    64 STAT3 inhibitor
    65 STAT5
    66 STAT5 proteins
    67 STATs
    68 activator
    69 activator of transcription
    70 age
    71 angiogenesis
    72 animal models
    73 anti-tumor immune response
    74 blood malignancies
    75 cancer therapy
    76 cells
    77 concept study
    78 continuous deregulation
    79 cytokines
    80 cytoplasmic transcription factors
    81 deregulation
    82 expression
    83 factors
    84 family proteins
    85 gene expression
    86 growth
    87 growth factor receptor
    88 human solid tumors
    89 immune response
    90 inhibition
    91 inhibitors
    92 latent cytoplasmic transcription factors
    93 malignancy
    94 model
    95 molecular targets
    96 normal cells
    97 novel cancer therapies
    98 nuclear gene expression
    99 nucleus
    100 partial inhibition
    101 persistent STAT3
    102 progression
    103 protein
    104 receptors
    105 response
    106 signals
    107 small molecule inhibitors
    108 solid tumors
    109 study
    110 survival
    111 target
    112 therapeutic window
    113 therapy
    114 transcription
    115 transcription factors
    116 transducer
    117 tumor angiogenesis
    118 tumor cells
    119 tumor progression
    120 tumors
    121 variety
    122 window
    123 schema:name The STATs of cancer — new molecular targets come of age
    124 schema:pagination 97-105
    125 schema:productId N12b4a3933be546f4bed8ed656e6e0114
    126 N39965d7a50a5448aa68afe38d5d333c9
    127 Nf92df6f3c0864530a2c6ee0300cd822f
    128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031068002
    129 https://doi.org/10.1038/nrc1275
    130 schema:sdDatePublished 2022-08-04T16:55
    131 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    132 schema:sdPublisher N71375dc993b54ba0aa51754ca828c6f6
    133 schema:url https://doi.org/10.1038/nrc1275
    134 sgo:license sg:explorer/license/
    135 sgo:sdDataset articles
    136 rdf:type schema:ScholarlyArticle
    137 N12b4a3933be546f4bed8ed656e6e0114 schema:name doi
    138 schema:value 10.1038/nrc1275
    139 rdf:type schema:PropertyValue
    140 N130ba57a07d8429abdf309bd6a3d4ef2 schema:volumeNumber 4
    141 rdf:type schema:PublicationVolume
    142 N14b7fcac954e4ea2a0f0ec0503c28dab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Cell Division
    144 rdf:type schema:DefinedTerm
    145 N1cf35a78ec3b415bb3c1cd7b1db0b7a6 rdf:first sg:person.0613555447.67
    146 rdf:rest rdf:nil
    147 N2d2f6bbc44444b44a00252618dd0cc90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Humans
    149 rdf:type schema:DefinedTerm
    150 N39965d7a50a5448aa68afe38d5d333c9 schema:name pubmed_id
    151 schema:value 14964307
    152 rdf:type schema:PropertyValue
    153 N5471bf0c8e49438dbb0ccbbad88f2889 schema:issueNumber 2
    154 rdf:type schema:PublicationIssue
    155 N63b95754c163457ab83b165579f06a27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name DNA-Binding Proteins
    157 rdf:type schema:DefinedTerm
    158 N68e179f3e45b4582a4cb385066a1b9a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Trans-Activators
    160 rdf:type schema:DefinedTerm
    161 N71375dc993b54ba0aa51754ca828c6f6 schema:name Springer Nature - SN SciGraph project
    162 rdf:type schema:Organization
    163 N96c58fbb2c224c26872656cb6b5e00fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Neovascularization, Pathologic
    165 rdf:type schema:DefinedTerm
    166 N9bdb9ec2f4ee4804b40ff469e8024d10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Apoptosis
    168 rdf:type schema:DefinedTerm
    169 Naf00ee38640d435e9e4a30fa381d0e6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name STAT5 Transcription Factor
    171 rdf:type schema:DefinedTerm
    172 Nb0751ad209a14eefa68ebc6a2ec70ddc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Neoplasms
    174 rdf:type schema:DefinedTerm
    175 Nc3c62fcf291a434a9fff5cdab6146b4f rdf:first sg:person.01322016332.33
    176 rdf:rest N1cf35a78ec3b415bb3c1cd7b1db0b7a6
    177 Nf7a76d1931ba4031a9313547e079f103 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Milk Proteins
    179 rdf:type schema:DefinedTerm
    180 Nf92df6f3c0864530a2c6ee0300cd822f schema:name dimensions_id
    181 schema:value pub.1031068002
    182 rdf:type schema:PropertyValue
    183 Nfd6f2ce6531146ebaafb9db922377c25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name STAT2 Transcription Factor
    185 rdf:type schema:DefinedTerm
    186 Nffda4b06ba294dbebab5cec0b58940b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Signal Transduction
    188 rdf:type schema:DefinedTerm
    189 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    190 schema:name Medical and Health Sciences
    191 rdf:type schema:DefinedTerm
    192 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    193 schema:name Oncology and Carcinogenesis
    194 rdf:type schema:DefinedTerm
    195 sg:journal.1029716 schema:issn 1474-175X
    196 1474-1768
    197 schema:name Nature Reviews Cancer
    198 schema:publisher Springer Nature
    199 rdf:type schema:Periodical
    200 sg:person.01322016332.33 schema:affiliation grid-institutes:grid.170693.a
    201 schema:familyName Yu
    202 schema:givenName Hua
    203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322016332.33
    204 rdf:type schema:Person
    205 sg:person.0613555447.67 schema:affiliation grid-institutes:grid.170693.a
    206 schema:familyName Jove
    207 schema:givenName Richard
    208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613555447.67
    209 rdf:type schema:Person
    210 sg:pub.10.1007/0-306-48158-8_11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021261427
    211 https://doi.org/10.1007/0-306-48158-8_11
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1038/35016125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045061122
    214 https://doi.org/10.1038/35016125
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/35042675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023763406
    217 https://doi.org/10.1038/35042675
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1038/35074122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001419011
    220 https://doi.org/10.1038/35074122
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1038/35077225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037528958
    223 https://doi.org/10.1038/35077225
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1038/359845a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021927273
    226 https://doi.org/10.1038/359845a0
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1038/365781a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020168730
    229 https://doi.org/10.1038/365781a0
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/367576a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016282476
    232 https://doi.org/10.1038/367576a0
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/ng0501-29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003632653
    235 https://doi.org/10.1038/ng0501-29
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/nm1096-1096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021940849
    238 https://doi.org/10.1038/nm1096-1096
    239 rdf:type schema:CreativeWork
    240 sg:pub.10.1038/nm976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049736419
    241 https://doi.org/10.1038/nm976
    242 rdf:type schema:CreativeWork
    243 sg:pub.10.1038/nrc1187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034382167
    244 https://doi.org/10.1038/nrc1187
    245 rdf:type schema:CreativeWork
    246 sg:pub.10.1038/nrc839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014023118
    247 https://doi.org/10.1038/nrc839
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1038/nrc906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046543214
    250 https://doi.org/10.1038/nrc906
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1038/nri774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045044815
    253 https://doi.org/10.1038/nri774
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/nrm909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045111933
    256 https://doi.org/10.1038/nrm909
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/sj.onc.1202727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016362345
    259 https://doi.org/10.1038/sj.onc.1202727
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/sj.onc.1203476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009697050
    262 https://doi.org/10.1038/sj.onc.1203476
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/sj.onc.1203478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002051407
    265 https://doi.org/10.1038/sj.onc.1203478
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/sj.onc.1203483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005181530
    268 https://doi.org/10.1038/sj.onc.1203483
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/sj.onc.1203484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005311964
    271 https://doi.org/10.1038/sj.onc.1203484
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/sj.onc.1203486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027056444
    274 https://doi.org/10.1038/sj.onc.1203486
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1038/sj.onc.1203522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019679218
    277 https://doi.org/10.1038/sj.onc.1203522
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1038/sj.onc.1203527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007050008
    280 https://doi.org/10.1038/sj.onc.1203527
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1038/sj.onc.1203551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026415083
    283 https://doi.org/10.1038/sj.onc.1203551
    284 rdf:type schema:CreativeWork
    285 sg:pub.10.1038/sj.onc.1203594 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019935517
    286 https://doi.org/10.1038/sj.onc.1203594
    287 rdf:type schema:CreativeWork
    288 sg:pub.10.1038/sj.onc.1203912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036305391
    289 https://doi.org/10.1038/sj.onc.1203912
    290 rdf:type schema:CreativeWork
    291 sg:pub.10.1038/sj.onc.1203947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029504869
    292 https://doi.org/10.1038/sj.onc.1203947
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1038/sj.onc.1204086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015007460
    295 https://doi.org/10.1038/sj.onc.1204086
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1038/sj.onc.1204349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003489702
    298 https://doi.org/10.1038/sj.onc.1204349
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1038/sj.onc.1205004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023491583
    301 https://doi.org/10.1038/sj.onc.1205004
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1038/sj.onc.1205152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042163942
    304 https://doi.org/10.1038/sj.onc.1205152
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1038/sj.onc.1205260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006935562
    307 https://doi.org/10.1038/sj.onc.1205260
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1038/sj.onc.1205859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014860210
    310 https://doi.org/10.1038/sj.onc.1205859
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1038/sj.onc.1206028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001510184
    313 https://doi.org/10.1038/sj.onc.1206028
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1038/sj.onc.1206122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041380684
    316 https://doi.org/10.1038/sj.onc.1206122
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1038/sj.onc.1206226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008616882
    319 https://doi.org/10.1038/sj.onc.1206226
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1038/sj.onc.1206479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041803871
    322 https://doi.org/10.1038/sj.onc.1206479
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1186/1471-2407-3-23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016396934
    325 https://doi.org/10.1186/1471-2407-3-23
    326 rdf:type schema:CreativeWork
    327 grid-institutes:grid.170693.a schema:alternateName H. Lee Moffitt Cancer Center and Research Institute and Department of Interdisciplinary Oncology, Molecular Oncology Program, University of South Florida College of Medicine, 33612, Tampa, Florida, USA
    328 Immunology Program and Department of Interdisciplinary Oncology, University of South Florida College of Medicine, 33612, Tampa, Florida, USA
    329 schema:name H. Lee Moffitt Cancer Center and Research Institute and Department of Interdisciplinary Oncology, Molecular Oncology Program, University of South Florida College of Medicine, 33612, Tampa, Florida, USA
    330 Immunology Program and Department of Interdisciplinary Oncology, University of South Florida College of Medicine, 33612, Tampa, Florida, USA
    331 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...