Searching for the elusive targets of farnesyltransferase inhibitors View Full Text


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Article Info

DATE

2003-12

AUTHORS

Saïd M Sebti, Channing J Der

ABSTRACT

Farnesyltransferase (FTase) inhibitors (FTIs) were developed originally as anti-RAS compounds and novel target-based drugs for cancer treatment. The analyses of FTIs continue in the clinic, but the antitumour activity cannot be ascribed simply to inhibition of RAS. Although FTI action is due to inhibition of FTase, and RAS proteins are indeed substrates for this enzyme, the RAS proteins that are most frequently mutated in human cancers escape FTI inhibition. RHOB has been suggested as a target, but is this issue resolved or do the crucial targets of FTIs remain to be identified? More... »

PAGES

945-951

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc1234

    DOI

    http://dx.doi.org/10.1038/nrc1234

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1016969921

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/14737124


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