Occurrence of leukaemia following gene therapy of X-linked SCID View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-07

AUTHORS

Donald B Kohn, Michel Sadelain, Joseph C Glorioso

ABSTRACT

Recombinant viral vectors have allowed gene transfer to be developed as a promising approach to the treatment of genetic diseases. Recently, gene therapy of children with X-linked severe combined immune deficiency resulted in impressive levels of immune reconstitution--a triumph that was later overshadowed by the development of leukaemia in two patients. What were the causes of this cancer, and how can the therapeutic benefits of gene therapy be achieved while minimizing risk to the patient? More... »

PAGES

477-488

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc1122

    DOI

    http://dx.doi.org/10.1038/nrc1122

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010076917

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12835668


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