RAS oncogenes: the first 30 years View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-06

AUTHORS

Marcos Malumbres, Mariano Barbacid

ABSTRACT

From the pioneering work with acute transforming retroviruses to the current post-genomic era, RAS genes have always been at the leading edge of signal transduction and molecular oncology. Yet, a complete understanding of RAS function and dysfunction — mainly in human cancer — is still to come. The knowledge that has accumulated since their discovery 30 years ago has, however, been remarkable, and should pave the way for not only solving the outstanding issues regarding RAS biology, but also for developing efficacious drugs that could have a significant impact on cancer treatment. More... »

PAGES

459-465

References to SciGraph publications

  • 1982-11. Mechanism of activation of a human oncogene in NATURE
  • 1982-07. T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes in NATURE
  • 1964-12. An Unidentified Virus which causes the Rapid Production of Tumours in Mice in NATURE
  • 1983-05. Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene in NATURE
  • 1987-05. Prevalence of ras gene mutations in human colorectal cancers in NATURE
  • 1982-11. A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene in NATURE
  • 1984-08. The p21 ras C-terminus is required for transformation and membrane association in NATURE
  • 2002-06-09. Mutations of the BRAF gene in human cancer in NATURE
  • 1998-06. Structural basis for the interaction of Ras with RaIGDS in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 1984-08. Comparative biochemical properties of normal and activated human ras p21 protein in NATURE
  • 1994-08. Phosphatidylinositol-3-OH kinase direct target of Ras in NATURE
  • 1985-01. Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells in NATURE
  • 1983-08. Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture in NATURE
  • 1992-03. C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains in NATURE
  • 1993-07. Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1 in NATURE
  • 1985-05. Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats in NATURE
  • 1982-06. Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene in NATURE
  • 1986-04. Requirement for c-ras proteins during viral oncogene transformation in NATURE
  • 2003-01. Targeting RAS signalling pathways in cancer therapy in NATURE REVIEWS CANCER
  • 1988-09-01. Cloning of bovine GAP and its interaction with oncogenic ras p21 in NATURE
  • 1982-12. Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change in NATURE
  • 1989-09. Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation in NATURE
  • 1993-05. How receptors turn Ras on in NATURE
  • 1993-05. C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation in NATURE
  • 2001-04-26. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice in NATURE
  • 2000-06-19. Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis in ONCOGENE
  • 1983-08. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes in NATURE
  • 1983-06. Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1 in NATURE
  • 1981-08. The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes in NATURE
  • 1998-07. The structural basis of the activation of Ras by Sos in NATURE
  • 1981-03. Transforming genes of carcinomas and neuroblastomas introduced into mouse fibroblasts in NATURE
  • 1982-04. Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells in NATURE
  • 1983-12. Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations in NATURE
  • 1990-05. Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis in NATURE
  • 1993-07. Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro in NATURE
  • 1999-07. Essential role for oncogenic Ras in tumour maintenance in NATURE
  • 1984-07. Epidermal growth factor stimulates guanine nucleotide binding activity and phosphorylation of ras oncogene proteins in NATURE
  • 1992-07. Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21 in NATURE
  • 1984-09. The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity in NATURE
  • 1995-08-01. Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice in NATURE MEDICINE
  • 1997-09. K-Ras is essential for the development of the mouse embryo in ONCOGENE
  • 1987-05. Detection of high incidence of K-ras oncogenes during human colon tumorigenesis in NATURE
  • 1984-02. Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas in NATURE
  • 1983-08. Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene in NATURE
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    DIMENSIONS

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