The genetics and mechanisms of T cell acute lymphoblastic leukaemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-08

AUTHORS

Laura Belver, Adolfo Ferrando

ABSTRACT

T cell acute lymphoblastic leukaemia (T-ALL) is an aggressive haematological malignancy derived from early T cell progenitors. In recent years genomic and transcriptomic studies have uncovered major oncogenic and tumour suppressor pathways involved in T-ALL transformation and identified distinct biological groups associated with prognosis. An increased understanding of T-ALL biology has already translated into new prognostic biomarkers and improved animal models of leukaemia and has opened opportunities for the development of targeted therapies for the treatment of this disease. In this Review we examine our current understanding of the molecular mechanisms of T-ALL and recent developments in the translation of these results to the clinic. More... »

PAGES

494-507

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    URI

    http://scigraph.springernature.com/pub.10.1038/nrc.2016.63

    DOI

    http://dx.doi.org/10.1038/nrc.2016.63

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1034012710

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27451956


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