The role of enhancers in cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-08

AUTHORS

Inderpreet Sur, Jussi Taipale

ABSTRACT

Enhancer elements function as the logic gates of the genetic regulatory circuitry. One of their most important functions is the integration of extracellular signals with intracellular cell fate information to generate cell type-specific transcriptional responses. Mutations occurring in cancer often misregulate enhancers that normally control the signal-dependent expression of growth-related genes. This misregulation can result from trans-acting mechanisms, such as activation of the transcription factors or epigenetic regulators that control enhancer activity, or can be caused in cis by direct mutations that alter the activity of the enhancer or its target gene specificity. These processes can generate tumour type-specific super-enhancers and establish a 'locked' gene regulatory state that drives the uncontrolled proliferation of cancer cells. Here, we review the role of enhancers in cancer, and their potential as therapeutic targets. More... »

PAGES

483-493

References to SciGraph publications

  • 2015-07. CTCF/cohesin-binding sites are frequently mutated in cancer in NATURE GENETICS
  • 2007-05. Genome-wide association study of prostate cancer identifies a second risk locus at 8q24 in NATURE GENETICS
  • 2010-09. Mediator and cohesin connect gene expression and chromatin architecture in NATURE
  • 2015-09. BET inhibitor resistance emerges from leukaemia stem cells in NATURE
  • 2015-07. Recurrent somatic mutations in regulatory regions of human cancer genomes in NATURE GENETICS
  • 2008-01. Predicting expression patterns from regulatory sequence in Drosophila segmentation in NATURE
  • 2015-10. Non-coding recurrent mutations in chronic lymphocytic leukaemia in NATURE
  • 2009-11. An oestrogen-receptor-α-bound human chromatin interactome in NATURE
  • 2006-07. Molecular cytogenetic study of 126 unselected T-ALL cases reveals high incidence of TCRβ locus rearrangements and putative new T-cell oncogenes in LEUKEMIA
  • 2013-06. Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data in NATURE REVIEWS GENETICS
  • 2014-11. Genome-wide analysis of noncoding regulatory mutations in cancer in NATURE GENETICS
  • 2007-08. Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24 in NATURE GENETICS
  • 2012-09. The accessible chromatin landscape of the human genome in NATURE
  • 2007-08. A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21 in NATURE GENETICS
  • 2012-08. Chromatin organization is a major influence on regional mutation rates in human cancer cells in NATURE
  • 2015-06. The emerging complexity of gene fusions in cancer in NATURE REVIEWS CANCER
  • 2014-02. A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding in NATURE GENETICS
  • 2011-03. Regulation of chromatin by histone modifications in CELL RESEARCH
  • 2010-12. Selective inhibition of BET bromodomains in NATURE
  • 2013-12. High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions in NATURE COMMUNICATIONS
  • 2015-02. Enhancer–core-promoter specificity separates developmental and housekeeping gene regulation in NATURE
  • 2013-11. Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer in NATURE REVIEWS GENETICS
  • 2014-01. Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair in NATURE BIOTECHNOLOGY
  • 2015-08. GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1 in SCIENTIFIC REPORTS
  • 2010-02. Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk in NATURE GENETICS
  • 2014-07. Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma in NATURE
  • 2015-12. Enrichment of inflammatory bowel disease and colorectal cancer risk variants in colon expression quantitative trait loci in BMC GENOMICS
  • 2013-10. Cancer drug resistance: an evolving paradigm in NATURE REVIEWS CANCER
  • 2011-08. Determinants and dynamics of genome accessibility in NATURE REVIEWS GENETICS
  • 2009-05. Histone modifications at human enhancers reflect global cell-type-specific gene expression in NATURE
  • 2004-03. A census of human cancer genes in NATURE REVIEWS CANCER
  • 2015-02. Cell-of-origin chromatin organization shapes the mutational landscape of cancer in NATURE
  • 2014-04. CTCF: an architectural protein bridging genome topology and function in NATURE REVIEWS GENETICS
  • 2013-03. DNA methylation of distal regulatory sites characterizes dysregulation of cancer genes in GENOME BIOLOGY
  • 2016-01. Insulator dysfunction and oncogene activation in IDH mutant gliomas in NATURE
  • 2016-02. Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers in NATURE GENETICS
  • 2014-07. In pursuit of design principles of regulatory sequences in NATURE REVIEWS GENETICS
  • 2015-01. Function and information content of DNA methylation in NATURE
  • 2015-03. DNMT3A in haematological malignancies in NATURE REVIEWS CANCER
  • 2015-04. The role of regulatory variation in complex traits and disease in NATURE REVIEWS GENETICS
  • 2006-06. A common variant associated with prostate cancer in European and African populations in NATURE GENETICS
  • 2015-09. Transcriptional plasticity promotes primary and acquired resistance to BET inhibition in NATURE
  • 2015-11-11. Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism in NATURE
  • 2012-03. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype in NATURE
  • 2010-02-18. The landscape of somatic copy-number alteration across human cancers in NATURE
  • 2012-03. IDH mutation impairs histone demethylation and results in a block to cell differentiation in NATURE
  • 2005-01. Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells in NATURE MEDICINE
  • 2005-01. Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway in NATURE MEDICINE
  • 2009-08. The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling in NATURE GENETICS
  • 2009-08. The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer in NATURE GENETICS
  • 2014-07-06. Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility in NATURE IMMUNOLOGY
  • 2007-04. The impact of translocations and gene fusions on cancer causation in NATURE REVIEWS CANCER
  • 2014-04. Transcriptional enhancers: from properties to genome-wide predictions in NATURE REVIEWS GENETICS
  • 2012-09. An integrated encyclopedia of DNA elements in the human genome in NATURE
  • 2009-08. H3.3/H2A.Z double variant–containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions in NATURE GENETICS
  • 2009-10. Identification of a new prostate cancer susceptibility locus on chromosome 8q24 in NATURE GENETICS
  • 2010-03. Principles and challenges of genome-wide DNA methylation analysis in NATURE REVIEWS GENETICS
  • 2010-11. Determining the specificity of protein–DNA interactions in NATURE REVIEWS GENETICS
  • 2012-04-11. Topological domains in mammalian genomes identified by analysis of chromatin interactions in NATURE
  • 2015-11. The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis in NATURE GENETICS
  • 2014-03. An atlas of active enhancers across human cell types and tissues in NATURE
  • 2007-03. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome in NATURE GENETICS
  • 2015-10. Mediator kinase inhibition further activates super-enhancer-associated genes in AML in NATURE
  • 2014-10. A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia in NATURE MEDICINE
  • 2006-11. In vivo enhancer analysis of human conserved non-coding sequences in NATURE
  • 2016-12. Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer in GENOME BIOLOGY
  • 2016-04. Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170 in NATURE GENETICS
  • 2014-08. Pan-cancer patterns of DNA methylation in GENOME MEDICINE
  • 2007-05. Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 in NATURE GENETICS
  • 2015-10. MYC: connecting selective transcriptional control to global RNA production in NATURE REVIEWS CANCER
  • 2014-01. Discovery and saturation analysis of cancer genes across 21 tumour types in NATURE
  • 2012-12. ChIP–seq and beyond: new and improved methodologies to detect and characterize protein–DNA interactions in NATURE REVIEWS GENETICS
  • 2013-07. Mutational heterogeneity in cancer and the search for new cancer-associated genes in NATURE
  • 2011-12-14. DNA-binding factors shape the mouse methylome at distal regulatory regions in NATURE
  • 2013-08. Signatures of mutational processes in human cancer in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc.2016.62

    DOI

    http://dx.doi.org/10.1038/nrc.2016.62

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1016983600

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27364481


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Enhancer Elements, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epigenesis, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Predisposition to Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Karolinska Institute", 
              "id": "https://www.grid.ac/institutes/grid.4714.6", 
              "name": [
                "Division of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, and Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm SE-171 77, Sweden."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sur", 
            "givenName": "Inderpreet", 
            "id": "sg:person.01330113145.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330113145.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Helsinki", 
              "id": "https://www.grid.ac/institutes/grid.7737.4", 
              "name": [
                "Division of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, and Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm SE-171 77, Sweden.", 
                "Genome-Scale Biology Program, University of Helsinki, Biomedicum, PO Box 63, Helsinki 00014, Finland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Taipale", 
            "givenName": "Jussi", 
            "id": "sg:person.0625474350.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625474350.36"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature10860", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000103968", 
              "https://doi.org/10.1038/nature10860"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3682", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000164192", 
              "https://doi.org/10.1038/nrg3682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14898", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000218710", 
              "https://doi.org/10.1038/nature14898"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.248526.114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000495179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2845", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000885038", 
              "https://doi.org/10.1038/nrg2845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2845", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000885038", 
              "https://doi.org/10.1038/nrg2845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1217277", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001335291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-4313", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001803874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001851540", 
              "https://doi.org/10.1038/nature09504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001851540", 
              "https://doi.org/10.1038/nature09504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002476578", 
              "https://doi.org/10.1038/ng.403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra0803109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002500139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(89)90916-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002557623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2014.08.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002800972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3306", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002837887", 
              "https://doi.org/10.1038/nrg3306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11232", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003040774", 
              "https://doi.org/10.1038/nature11232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng2022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003791570", 
              "https://doi.org/10.1038/ng2022"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng2022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003791570", 
              "https://doi.org/10.1038/ng2022"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature15540", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004331772", 
              "https://doi.org/10.1038/nature15540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09380", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004695178", 
              "https://doi.org/10.1038/nature09380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09380", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004695178", 
              "https://doi.org/10.1038/nature09380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkv1530", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005174154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.03.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005302017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkq929", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005486377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005628730", 
              "https://doi.org/10.1038/nrg3017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra0905980", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006094606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3554", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006119577", 
              "https://doi.org/10.1038/nrg3554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.166231.113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007039701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.166231.113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007039701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.136127.111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007044518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gde.2014.03.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007490995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1272505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007710897"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5483/bmbrep.2014.47.6.092", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007779597"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddg180", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008338421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1808", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008387561", 
              "https://doi.org/10.1038/ng1808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1808", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008387561", 
              "https://doi.org/10.1038/ng1808"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gde.2010.03.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008714894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05295", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009061596", 
              "https://doi.org/10.1038/nature05295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05295", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009061596", 
              "https://doi.org/10.1038/nature05295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05295", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009061596", 
              "https://doi.org/10.1038/nature05295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ydbio.2010.05.493", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009136530"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.09.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009620828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.11.050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009674515"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1966", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010017851", 
              "https://doi.org/10.1038/ng1966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2010.11.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010196923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010635813", 
              "https://doi.org/10.1038/nature08822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010635813", 
              "https://doi.org/10.1038/nature08822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10866", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010733927", 
              "https://doi.org/10.1038/nature10866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010889060", 
              "https://doi.org/10.1038/nature14192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.09.053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011111923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012147864", 
              "https://doi.org/10.1038/nature14221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13379", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014600483", 
              "https://doi.org/10.1038/nature13379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3665", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014690315", 
              "https://doi.org/10.1038/nm.3665"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.15.8681", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014931389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.r113.512517", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016089954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2862", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016123190", 
              "https://doi.org/10.1038/ng.2862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14904", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016854653", 
              "https://doi.org/10.1038/nature14904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1222794", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017092582"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature16490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017311368", 
              "https://doi.org/10.1038/nature16490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14666", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017405010", 
              "https://doi.org/10.1038/nature14666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.03.036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017590275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2010.10.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017676906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3663", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017831086", 
              "https://doi.org/10.1038/nrg3663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2012.11.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017949272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1506255112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018342866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1506255112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018342866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.409", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018502205", 
              "https://doi.org/10.1038/ng.409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.21.9700", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018690110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.10.042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018757310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13073-014-0066-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020107189", 
              "https://doi.org/10.1186/s13073-014-0066-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13073-014-0066-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020107189", 
              "https://doi.org/10.1186/s13073-014-0066-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tig.2014.07.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020150610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2011.22", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020222518", 
              "https://doi.org/10.1038/cr.2011.22"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0903103106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020299353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djn190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020895882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12864-015-1292-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020957879", 
              "https://doi.org/10.1186/s12864-015-1292-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12864-015-1292-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020957879", 
              "https://doi.org/10.1186/s12864-015-1292-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.012591199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021450538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2013.07.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021552264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms3218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021618987", 
              "https://doi.org/10.1038/ncomms3218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021761707", 
              "https://doi.org/10.1038/nature12213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.79.24.7837", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021868830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12787", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022158752", 
              "https://doi.org/10.1038/nature12787"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1000888", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022521320"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022731034", 
              "https://doi.org/10.1038/nrc1299"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022731034", 
              "https://doi.org/10.1038/nrc1299"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-13-2498", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023523845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1999", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023573468", 
              "https://doi.org/10.1038/ng1999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1999", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023573468", 
              "https://doi.org/10.1038/ng1999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.406", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023714573", 
              "https://doi.org/10.1038/ng.406"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.406", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023714573", 
              "https://doi.org/10.1038/ng.406"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3419", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023734926", 
              "https://doi.org/10.1038/ng.3419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07829", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023938796", 
              "https://doi.org/10.1038/nature07829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07829", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023938796", 
              "https://doi.org/10.1038/nature07829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.444", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025944023", 
              "https://doi.org/10.1038/ng.444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.444", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025944023", 
              "https://doi.org/10.1038/ng.444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3684", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025954650", 
              "https://doi.org/10.1038/nrg3684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2732", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026070037", 
              "https://doi.org/10.1038/nrg2732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2732", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026070037", 
              "https://doi.org/10.1038/nrg2732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.08.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026115083"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10716", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026180143", 
              "https://doi.org/10.1038/nature10716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.510", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026418435", 
              "https://doi.org/10.1038/ng.510"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.510", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026418435", 
              "https://doi.org/10.1038/ng.510"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3599", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026519625", 
              "https://doi.org/10.1038/nrc3599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2012.05.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027162735"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ymeth.2012.05.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027162735"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.180316197", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027811641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aad9024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028359583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.10.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028872258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028994999", 
              "https://doi.org/10.1038/nature11273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0910668107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029012444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029065430", 
              "https://doi.org/10.1038/nature11247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.79.24.7824", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029478335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/17.6.1788", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029574920"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1160", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029661228", 
              "https://doi.org/10.1038/nm1160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1160", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029661228", 
              "https://doi.org/10.1038/nm1160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3521", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029886099", 
              "https://doi.org/10.1038/ng.3521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.80.3.820", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029974447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2010.07.043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030203445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3984", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030316689", 
              "https://doi.org/10.1038/nrc3984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2015.02.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030943729"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tips.2013.11.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032986063"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3335", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033672099", 
              "https://doi.org/10.1038/ng.3335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13994", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033819095", 
              "https://doi.org/10.1038/nature13994"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034652452", 
              "https://doi.org/10.1038/ng.3101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.121541.111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035192436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibs.2014.02.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035488202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1235122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035954369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036599020", 
              "https://doi.org/10.1038/nature08497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036599020", 
              "https://doi.org/10.1038/nature08497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14888", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036615307", 
              "https://doi.org/10.1038/nature14888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13059-016-0879-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038383023", 
              "https://doi.org/10.1186/s13059-016-0879-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0105393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038695422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3895", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039113899", 
              "https://doi.org/10.1038/nrc3895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0092689", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039289301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-5766", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039624768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11082", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040271530", 
              "https://doi.org/10.1038/nature11082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3891", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040273548", 
              "https://doi.org/10.1038/nrg3891"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ppo.0b013e31823e5387", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041563583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ppo.0b013e31823e5387", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041563583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0114485", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041700241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2404243", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041729316", 
              "https://doi.org/10.1038/sj.leu.2404243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2404243", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041729316", 
              "https://doi.org/10.1038/sj.leu.2404243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1000597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041883716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2010.10.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042891274"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-13-0789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042942258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tig.2012.02.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043221975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12912", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043554069", 
              "https://doi.org/10.1038/nature12912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06496", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043696128", 
              "https://doi.org/10.1038/nature06496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2091", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043783272", 
              "https://doi.org/10.1038/nrc2091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1508736112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044011711"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng2089", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044276531", 
              "https://doi.org/10.1038/ng2089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/92.7.564", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044385773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0012112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044407216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1519286113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044437485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2778", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044493127", 
              "https://doi.org/10.1038/nbt.2778"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2013-14-3-r21", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044614468", 
              "https://doi.org/10.1186/gb-2013-14-3-r21"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0111914", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045630254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep09489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046032603", 
              "https://doi.org/10.1038/srep09489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3454", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046147193", 
              "https://doi.org/10.1038/nrg3454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3332", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046480318", 
              "https://doi.org/10.1038/ng.3332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1016071107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047051560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.03.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047212289"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.07.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047377535"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkt1229", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047459836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkt1229", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047459836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1259037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047749112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0307708100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047970186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2937", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048042150", 
              "https://doi.org/10.1038/ni.2937"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng2085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048660016", 
              "https://doi.org/10.1038/ng2085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2012-07-446120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049158420"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3947", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049444119", 
              "https://doi.org/10.1038/nrc3947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2014.05.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049496085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050004918", 
              "https://doi.org/10.1038/nature12477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci69738", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050409805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0049160", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051484867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.105361.110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051822451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.12.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051880006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3470", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052575383", 
              "https://doi.org/10.1038/ng.3470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1161", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052719546", 
              "https://doi.org/10.1038/nm1161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1161", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052719546", 
              "https://doi.org/10.1038/nm1161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1228606", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062467093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1229259", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062467132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1230062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062467697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.6414084", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062637543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-4608", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077108311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1989.tb03493.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079303815"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-08", 
        "datePublishedReg": "2016-08-01", 
        "description": "Enhancer elements function as the logic gates of the genetic regulatory circuitry. One of their most important functions is the integration of extracellular signals with intracellular cell fate information to generate cell type-specific transcriptional responses. Mutations occurring in cancer often misregulate enhancers that normally control the signal-dependent expression of growth-related genes. This misregulation can result from trans-acting mechanisms, such as activation of the transcription factors or epigenetic regulators that control enhancer activity, or can be caused in cis by direct mutations that alter the activity of the enhancer or its target gene specificity. These processes can generate tumour type-specific super-enhancers and establish a 'locked' gene regulatory state that drives the uncontrolled proliferation of cancer cells. Here, we review the role of enhancers in cancer, and their potential as therapeutic targets.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nrc.2016.62", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1029716", 
            "issn": [
              "1474-175X", 
              "1474-1768"
            ], 
            "name": "Nature Reviews Cancer", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "8", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "16"
          }
        ], 
        "name": "The role of enhancers in cancer", 
        "pagination": "483-493", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "50eac4226a8ac01b4f0ce722291606efd56d15b98bf8105d49e5159b0cd29b81"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27364481"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101124168"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nrc.2016.62"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1016983600"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nrc.2016.62", 
          "https://app.dimensions.ai/details/publication/pub.1016983600"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T00:03", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000424.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/nrc/journal/v16/n8/full/nrc.2016.62.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrc.2016.62'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrc.2016.62'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrc.2016.62'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrc.2016.62'


     

    This table displays all metadata directly associated to this object as RDF triples.

    666 TRIPLES      21 PREDICATES      197 URIs      28 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nrc.2016.62 schema:about N62b04bf81ee74cdeb318c6b0e747fb87
    2 N6f5f0d233a0b43f884f5894d4630be6d
    3 N9d71ab94dd1e45f988da8ae45a888613
    4 Nb4b765461b8c415e89413d3937e2ea14
    5 Ncee00876b44145fcb59102e632ac8f73
    6 Ne6d758d2acea4b468e4b56483cf964e1
    7 Nfcd98a6e531747639aa16dc2e27cd90e
    8 anzsrc-for:06
    9 anzsrc-for:0604
    10 schema:author N1831b53ba7f7491aa539cb2cf023228a
    11 schema:citation sg:pub.10.1038/cr.2011.22
    12 sg:pub.10.1038/nature05295
    13 sg:pub.10.1038/nature06496
    14 sg:pub.10.1038/nature07829
    15 sg:pub.10.1038/nature08497
    16 sg:pub.10.1038/nature08822
    17 sg:pub.10.1038/nature09380
    18 sg:pub.10.1038/nature09504
    19 sg:pub.10.1038/nature10716
    20 sg:pub.10.1038/nature10860
    21 sg:pub.10.1038/nature10866
    22 sg:pub.10.1038/nature11082
    23 sg:pub.10.1038/nature11232
    24 sg:pub.10.1038/nature11247
    25 sg:pub.10.1038/nature11273
    26 sg:pub.10.1038/nature12213
    27 sg:pub.10.1038/nature12477
    28 sg:pub.10.1038/nature12787
    29 sg:pub.10.1038/nature12912
    30 sg:pub.10.1038/nature13379
    31 sg:pub.10.1038/nature13994
    32 sg:pub.10.1038/nature14192
    33 sg:pub.10.1038/nature14221
    34 sg:pub.10.1038/nature14666
    35 sg:pub.10.1038/nature14888
    36 sg:pub.10.1038/nature14898
    37 sg:pub.10.1038/nature14904
    38 sg:pub.10.1038/nature15540
    39 sg:pub.10.1038/nature16490
    40 sg:pub.10.1038/nbt.2778
    41 sg:pub.10.1038/ncomms3218
    42 sg:pub.10.1038/ng.2862
    43 sg:pub.10.1038/ng.3101
    44 sg:pub.10.1038/ng.3332
    45 sg:pub.10.1038/ng.3335
    46 sg:pub.10.1038/ng.3419
    47 sg:pub.10.1038/ng.3470
    48 sg:pub.10.1038/ng.3521
    49 sg:pub.10.1038/ng.403
    50 sg:pub.10.1038/ng.406
    51 sg:pub.10.1038/ng.409
    52 sg:pub.10.1038/ng.444
    53 sg:pub.10.1038/ng.510
    54 sg:pub.10.1038/ng1808
    55 sg:pub.10.1038/ng1966
    56 sg:pub.10.1038/ng1999
    57 sg:pub.10.1038/ng2022
    58 sg:pub.10.1038/ng2085
    59 sg:pub.10.1038/ng2089
    60 sg:pub.10.1038/ni.2937
    61 sg:pub.10.1038/nm.3665
    62 sg:pub.10.1038/nm1160
    63 sg:pub.10.1038/nm1161
    64 sg:pub.10.1038/nrc1299
    65 sg:pub.10.1038/nrc2091
    66 sg:pub.10.1038/nrc3599
    67 sg:pub.10.1038/nrc3895
    68 sg:pub.10.1038/nrc3947
    69 sg:pub.10.1038/nrc3984
    70 sg:pub.10.1038/nrg2732
    71 sg:pub.10.1038/nrg2845
    72 sg:pub.10.1038/nrg3017
    73 sg:pub.10.1038/nrg3306
    74 sg:pub.10.1038/nrg3454
    75 sg:pub.10.1038/nrg3554
    76 sg:pub.10.1038/nrg3663
    77 sg:pub.10.1038/nrg3682
    78 sg:pub.10.1038/nrg3684
    79 sg:pub.10.1038/nrg3891
    80 sg:pub.10.1038/sj.leu.2404243
    81 sg:pub.10.1038/srep09489
    82 sg:pub.10.1186/gb-2013-14-3-r21
    83 sg:pub.10.1186/s12864-015-1292-z
    84 sg:pub.10.1186/s13059-016-0879-2
    85 sg:pub.10.1186/s13073-014-0066-6
    86 https://doi.org/10.1002/j.1460-2075.1989.tb03493.x
    87 https://doi.org/10.1016/0092-8674(89)90916-1
    88 https://doi.org/10.1016/j.ccr.2010.10.022
    89 https://doi.org/10.1016/j.ccr.2010.11.015
    90 https://doi.org/10.1016/j.ccr.2013.07.007
    91 https://doi.org/10.1016/j.cell.2005.10.042
    92 https://doi.org/10.1016/j.cell.2011.08.017
    93 https://doi.org/10.1016/j.cell.2012.12.034
    94 https://doi.org/10.1016/j.cell.2013.03.002
    95 https://doi.org/10.1016/j.cell.2013.03.035
    96 https://doi.org/10.1016/j.cell.2013.03.036
    97 https://doi.org/10.1016/j.cell.2013.07.034
    98 https://doi.org/10.1016/j.cell.2013.09.053
    99 https://doi.org/10.1016/j.cell.2014.09.030
    100 https://doi.org/10.1016/j.cell.2014.10.024
    101 https://doi.org/10.1016/j.cell.2015.11.050
    102 https://doi.org/10.1016/j.celrep.2014.08.025
    103 https://doi.org/10.1016/j.cub.2010.07.043
    104 https://doi.org/10.1016/j.devcel.2010.10.006
    105 https://doi.org/10.1016/j.gde.2010.03.012
    106 https://doi.org/10.1016/j.gde.2014.03.014
    107 https://doi.org/10.1016/j.molcel.2015.02.014
    108 https://doi.org/10.1016/j.stem.2012.11.003
    109 https://doi.org/10.1016/j.stem.2014.05.017
    110 https://doi.org/10.1016/j.tibs.2014.02.007
    111 https://doi.org/10.1016/j.tig.2012.02.008
    112 https://doi.org/10.1016/j.tig.2014.07.005
    113 https://doi.org/10.1016/j.tips.2013.11.004
    114 https://doi.org/10.1016/j.ydbio.2010.05.493
    115 https://doi.org/10.1016/j.ymeth.2012.05.001
    116 https://doi.org/10.1056/nejmra0803109
    117 https://doi.org/10.1056/nejmra0905980
    118 https://doi.org/10.1073/pnas.012591199
    119 https://doi.org/10.1073/pnas.0307708100
    120 https://doi.org/10.1073/pnas.0903103106
    121 https://doi.org/10.1073/pnas.0910668107
    122 https://doi.org/10.1073/pnas.1016071107
    123 https://doi.org/10.1073/pnas.1506255112
    124 https://doi.org/10.1073/pnas.1508736112
    125 https://doi.org/10.1073/pnas.1519286113
    126 https://doi.org/10.1073/pnas.180316197
    127 https://doi.org/10.1073/pnas.79.24.7824
    128 https://doi.org/10.1073/pnas.79.24.7837
    129 https://doi.org/10.1073/pnas.80.3.820
    130 https://doi.org/10.1073/pnas.91.21.9700
    131 https://doi.org/10.1073/pnas.96.15.8681
    132 https://doi.org/10.1074/jbc.r113.512517
    133 https://doi.org/10.1093/emboj/17.6.1788
    134 https://doi.org/10.1093/hmg/ddg180
    135 https://doi.org/10.1093/jnci/92.7.564
    136 https://doi.org/10.1093/jnci/djn190
    137 https://doi.org/10.1093/nar/gkq929
    138 https://doi.org/10.1093/nar/gkt1229
    139 https://doi.org/10.1093/nar/gkv1530
    140 https://doi.org/10.1097/ppo.0b013e31823e5387
    141 https://doi.org/10.1101/gad.1272505
    142 https://doi.org/10.1101/gad.248526.114
    143 https://doi.org/10.1101/gr.105361.110
    144 https://doi.org/10.1101/gr.121541.111
    145 https://doi.org/10.1101/gr.136127.111
    146 https://doi.org/10.1101/gr.166231.113
    147 https://doi.org/10.1126/science.1217277
    148 https://doi.org/10.1126/science.1222794
    149 https://doi.org/10.1126/science.1228606
    150 https://doi.org/10.1126/science.1229259
    151 https://doi.org/10.1126/science.1230062
    152 https://doi.org/10.1126/science.1235122
    153 https://doi.org/10.1126/science.1259037
    154 https://doi.org/10.1126/science.6414084
    155 https://doi.org/10.1126/science.aad9024
    156 https://doi.org/10.1158/0008-5472.can-04-4313
    157 https://doi.org/10.1158/0008-5472.can-04-4608
    158 https://doi.org/10.1158/0008-5472.can-07-5766
    159 https://doi.org/10.1158/0008-5472.can-13-0789
    160 https://doi.org/10.1158/0008-5472.can-13-2498
    161 https://doi.org/10.1172/jci69738
    162 https://doi.org/10.1182/blood-2012-07-446120
    163 https://doi.org/10.1371/journal.pgen.1000597
    164 https://doi.org/10.1371/journal.pgen.1000888
    165 https://doi.org/10.1371/journal.pone.0012112
    166 https://doi.org/10.1371/journal.pone.0049160
    167 https://doi.org/10.1371/journal.pone.0092689
    168 https://doi.org/10.1371/journal.pone.0105393
    169 https://doi.org/10.1371/journal.pone.0111914
    170 https://doi.org/10.1371/journal.pone.0114485
    171 https://doi.org/10.5483/bmbrep.2014.47.6.092
    172 schema:datePublished 2016-08
    173 schema:datePublishedReg 2016-08-01
    174 schema:description Enhancer elements function as the logic gates of the genetic regulatory circuitry. One of their most important functions is the integration of extracellular signals with intracellular cell fate information to generate cell type-specific transcriptional responses. Mutations occurring in cancer often misregulate enhancers that normally control the signal-dependent expression of growth-related genes. This misregulation can result from trans-acting mechanisms, such as activation of the transcription factors or epigenetic regulators that control enhancer activity, or can be caused in cis by direct mutations that alter the activity of the enhancer or its target gene specificity. These processes can generate tumour type-specific super-enhancers and establish a 'locked' gene regulatory state that drives the uncontrolled proliferation of cancer cells. Here, we review the role of enhancers in cancer, and their potential as therapeutic targets.
    175 schema:genre research_article
    176 schema:inLanguage en
    177 schema:isAccessibleForFree false
    178 schema:isPartOf N64fe7db66eab4eee840f2a056c0e76bc
    179 N952c93cdfdb74ebcb610b45a1c1b8c74
    180 sg:journal.1029716
    181 schema:name The role of enhancers in cancer
    182 schema:pagination 483-493
    183 schema:productId N2874e81459014dac9994e2a1a0b49c5c
    184 N29a0d19f2ddc46f08ffc1d26f87e9a33
    185 N3234a016cf7843599dc0808a00752ef0
    186 N3709dd9a9d1144bf9602d3e43d795d17
    187 Na5018647c20a462ea623f208e7bd7acf
    188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016983600
    189 https://doi.org/10.1038/nrc.2016.62
    190 schema:sdDatePublished 2019-04-11T00:03
    191 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    192 schema:sdPublisher Nb2eaa22d5c114acfae21b2004af4c20c
    193 schema:url http://www.nature.com/nrc/journal/v16/n8/full/nrc.2016.62.html
    194 sgo:license sg:explorer/license/
    195 sgo:sdDataset articles
    196 rdf:type schema:ScholarlyArticle
    197 N1831b53ba7f7491aa539cb2cf023228a rdf:first sg:person.01330113145.53
    198 rdf:rest N8caff8537ad14f93aa11b9fcff511c1d
    199 N2874e81459014dac9994e2a1a0b49c5c schema:name pubmed_id
    200 schema:value 27364481
    201 rdf:type schema:PropertyValue
    202 N29a0d19f2ddc46f08ffc1d26f87e9a33 schema:name nlm_unique_id
    203 schema:value 101124168
    204 rdf:type schema:PropertyValue
    205 N3234a016cf7843599dc0808a00752ef0 schema:name dimensions_id
    206 schema:value pub.1016983600
    207 rdf:type schema:PropertyValue
    208 N3709dd9a9d1144bf9602d3e43d795d17 schema:name doi
    209 schema:value 10.1038/nrc.2016.62
    210 rdf:type schema:PropertyValue
    211 N62b04bf81ee74cdeb318c6b0e747fb87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Genetic Predisposition to Disease
    213 rdf:type schema:DefinedTerm
    214 N64fe7db66eab4eee840f2a056c0e76bc schema:issueNumber 8
    215 rdf:type schema:PublicationIssue
    216 N6f5f0d233a0b43f884f5894d4630be6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    217 schema:name Enhancer Elements, Genetic
    218 rdf:type schema:DefinedTerm
    219 N8caff8537ad14f93aa11b9fcff511c1d rdf:first sg:person.0625474350.36
    220 rdf:rest rdf:nil
    221 N952c93cdfdb74ebcb610b45a1c1b8c74 schema:volumeNumber 16
    222 rdf:type schema:PublicationVolume
    223 N9d71ab94dd1e45f988da8ae45a888613 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    224 schema:name Female
    225 rdf:type schema:DefinedTerm
    226 Na5018647c20a462ea623f208e7bd7acf schema:name readcube_id
    227 schema:value 50eac4226a8ac01b4f0ce722291606efd56d15b98bf8105d49e5159b0cd29b81
    228 rdf:type schema:PropertyValue
    229 Nb2eaa22d5c114acfae21b2004af4c20c schema:name Springer Nature - SN SciGraph project
    230 rdf:type schema:Organization
    231 Nb4b765461b8c415e89413d3937e2ea14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    232 schema:name Epigenesis, Genetic
    233 rdf:type schema:DefinedTerm
    234 Ncee00876b44145fcb59102e632ac8f73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    235 schema:name Humans
    236 rdf:type schema:DefinedTerm
    237 Ne6d758d2acea4b468e4b56483cf964e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    238 schema:name Male
    239 rdf:type schema:DefinedTerm
    240 Nfcd98a6e531747639aa16dc2e27cd90e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    241 schema:name Neoplasms
    242 rdf:type schema:DefinedTerm
    243 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    244 schema:name Biological Sciences
    245 rdf:type schema:DefinedTerm
    246 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    247 schema:name Genetics
    248 rdf:type schema:DefinedTerm
    249 sg:journal.1029716 schema:issn 1474-175X
    250 1474-1768
    251 schema:name Nature Reviews Cancer
    252 rdf:type schema:Periodical
    253 sg:person.01330113145.53 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
    254 schema:familyName Sur
    255 schema:givenName Inderpreet
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330113145.53
    257 rdf:type schema:Person
    258 sg:person.0625474350.36 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
    259 schema:familyName Taipale
    260 schema:givenName Jussi
    261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625474350.36
    262 rdf:type schema:Person
    263 sg:pub.10.1038/cr.2011.22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020222518
    264 https://doi.org/10.1038/cr.2011.22
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1038/nature05295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009061596
    267 https://doi.org/10.1038/nature05295
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1038/nature06496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043696128
    270 https://doi.org/10.1038/nature06496
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/nature07829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023938796
    273 https://doi.org/10.1038/nature07829
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/nature08497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036599020
    276 https://doi.org/10.1038/nature08497
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/nature08822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010635813
    279 https://doi.org/10.1038/nature08822
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/nature09380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004695178
    282 https://doi.org/10.1038/nature09380
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/nature09504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001851540
    285 https://doi.org/10.1038/nature09504
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/nature10716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026180143
    288 https://doi.org/10.1038/nature10716
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/nature10860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000103968
    291 https://doi.org/10.1038/nature10860
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1038/nature10866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010733927
    294 https://doi.org/10.1038/nature10866
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/nature11082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040271530
    297 https://doi.org/10.1038/nature11082
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/nature11232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003040774
    300 https://doi.org/10.1038/nature11232
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1038/nature11247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029065430
    303 https://doi.org/10.1038/nature11247
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1038/nature11273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028994999
    306 https://doi.org/10.1038/nature11273
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1038/nature12213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021761707
    309 https://doi.org/10.1038/nature12213
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1038/nature12477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050004918
    312 https://doi.org/10.1038/nature12477
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1038/nature12787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022158752
    315 https://doi.org/10.1038/nature12787
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1038/nature12912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043554069
    318 https://doi.org/10.1038/nature12912
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1038/nature13379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014600483
    321 https://doi.org/10.1038/nature13379
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1038/nature13994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033819095
    324 https://doi.org/10.1038/nature13994
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1038/nature14192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010889060
    327 https://doi.org/10.1038/nature14192
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1038/nature14221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012147864
    330 https://doi.org/10.1038/nature14221
    331 rdf:type schema:CreativeWork
    332 sg:pub.10.1038/nature14666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017405010
    333 https://doi.org/10.1038/nature14666
    334 rdf:type schema:CreativeWork
    335 sg:pub.10.1038/nature14888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036615307
    336 https://doi.org/10.1038/nature14888
    337 rdf:type schema:CreativeWork
    338 sg:pub.10.1038/nature14898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000218710
    339 https://doi.org/10.1038/nature14898
    340 rdf:type schema:CreativeWork
    341 sg:pub.10.1038/nature14904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016854653
    342 https://doi.org/10.1038/nature14904
    343 rdf:type schema:CreativeWork
    344 sg:pub.10.1038/nature15540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004331772
    345 https://doi.org/10.1038/nature15540
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1038/nature16490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017311368
    348 https://doi.org/10.1038/nature16490
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1038/nbt.2778 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044493127
    351 https://doi.org/10.1038/nbt.2778
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1038/ncomms3218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021618987
    354 https://doi.org/10.1038/ncomms3218
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1038/ng.2862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016123190
    357 https://doi.org/10.1038/ng.2862
    358 rdf:type schema:CreativeWork
    359 sg:pub.10.1038/ng.3101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034652452
    360 https://doi.org/10.1038/ng.3101
    361 rdf:type schema:CreativeWork
    362 sg:pub.10.1038/ng.3332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046480318
    363 https://doi.org/10.1038/ng.3332
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1038/ng.3335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033672099
    366 https://doi.org/10.1038/ng.3335
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1038/ng.3419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023734926
    369 https://doi.org/10.1038/ng.3419
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1038/ng.3470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052575383
    372 https://doi.org/10.1038/ng.3470
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1038/ng.3521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029886099
    375 https://doi.org/10.1038/ng.3521
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1038/ng.403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002476578
    378 https://doi.org/10.1038/ng.403
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1038/ng.406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023714573
    381 https://doi.org/10.1038/ng.406
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1038/ng.409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018502205
    384 https://doi.org/10.1038/ng.409
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1038/ng.444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025944023
    387 https://doi.org/10.1038/ng.444
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1038/ng.510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026418435
    390 https://doi.org/10.1038/ng.510
    391 rdf:type schema:CreativeWork
    392 sg:pub.10.1038/ng1808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008387561
    393 https://doi.org/10.1038/ng1808
    394 rdf:type schema:CreativeWork
    395 sg:pub.10.1038/ng1966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010017851
    396 https://doi.org/10.1038/ng1966
    397 rdf:type schema:CreativeWork
    398 sg:pub.10.1038/ng1999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023573468
    399 https://doi.org/10.1038/ng1999
    400 rdf:type schema:CreativeWork
    401 sg:pub.10.1038/ng2022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003791570
    402 https://doi.org/10.1038/ng2022
    403 rdf:type schema:CreativeWork
    404 sg:pub.10.1038/ng2085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048660016
    405 https://doi.org/10.1038/ng2085
    406 rdf:type schema:CreativeWork
    407 sg:pub.10.1038/ng2089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044276531
    408 https://doi.org/10.1038/ng2089
    409 rdf:type schema:CreativeWork
    410 sg:pub.10.1038/ni.2937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048042150
    411 https://doi.org/10.1038/ni.2937
    412 rdf:type schema:CreativeWork
    413 sg:pub.10.1038/nm.3665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014690315
    414 https://doi.org/10.1038/nm.3665
    415 rdf:type schema:CreativeWork
    416 sg:pub.10.1038/nm1160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029661228
    417 https://doi.org/10.1038/nm1160
    418 rdf:type schema:CreativeWork
    419 sg:pub.10.1038/nm1161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052719546
    420 https://doi.org/10.1038/nm1161
    421 rdf:type schema:CreativeWork
    422 sg:pub.10.1038/nrc1299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022731034
    423 https://doi.org/10.1038/nrc1299
    424 rdf:type schema:CreativeWork
    425 sg:pub.10.1038/nrc2091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043783272
    426 https://doi.org/10.1038/nrc2091
    427 rdf:type schema:CreativeWork
    428 sg:pub.10.1038/nrc3599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026519625
    429 https://doi.org/10.1038/nrc3599
    430 rdf:type schema:CreativeWork
    431 sg:pub.10.1038/nrc3895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039113899
    432 https://doi.org/10.1038/nrc3895
    433 rdf:type schema:CreativeWork
    434 sg:pub.10.1038/nrc3947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049444119
    435 https://doi.org/10.1038/nrc3947
    436 rdf:type schema:CreativeWork
    437 sg:pub.10.1038/nrc3984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030316689
    438 https://doi.org/10.1038/nrc3984
    439 rdf:type schema:CreativeWork
    440 sg:pub.10.1038/nrg2732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026070037
    441 https://doi.org/10.1038/nrg2732
    442 rdf:type schema:CreativeWork
    443 sg:pub.10.1038/nrg2845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000885038
    444 https://doi.org/10.1038/nrg2845
    445 rdf:type schema:CreativeWork
    446 sg:pub.10.1038/nrg3017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005628730
    447 https://doi.org/10.1038/nrg3017
    448 rdf:type schema:CreativeWork
    449 sg:pub.10.1038/nrg3306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002837887
    450 https://doi.org/10.1038/nrg3306
    451 rdf:type schema:CreativeWork
    452 sg:pub.10.1038/nrg3454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046147193
    453 https://doi.org/10.1038/nrg3454
    454 rdf:type schema:CreativeWork
    455 sg:pub.10.1038/nrg3554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006119577
    456 https://doi.org/10.1038/nrg3554
    457 rdf:type schema:CreativeWork
    458 sg:pub.10.1038/nrg3663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017831086
    459 https://doi.org/10.1038/nrg3663
    460 rdf:type schema:CreativeWork
    461 sg:pub.10.1038/nrg3682 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000164192
    462 https://doi.org/10.1038/nrg3682
    463 rdf:type schema:CreativeWork
    464 sg:pub.10.1038/nrg3684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025954650
    465 https://doi.org/10.1038/nrg3684
    466 rdf:type schema:CreativeWork
    467 sg:pub.10.1038/nrg3891 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040273548
    468 https://doi.org/10.1038/nrg3891
    469 rdf:type schema:CreativeWork
    470 sg:pub.10.1038/sj.leu.2404243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041729316
    471 https://doi.org/10.1038/sj.leu.2404243
    472 rdf:type schema:CreativeWork
    473 sg:pub.10.1038/srep09489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046032603
    474 https://doi.org/10.1038/srep09489
    475 rdf:type schema:CreativeWork
    476 sg:pub.10.1186/gb-2013-14-3-r21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044614468
    477 https://doi.org/10.1186/gb-2013-14-3-r21
    478 rdf:type schema:CreativeWork
    479 sg:pub.10.1186/s12864-015-1292-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1020957879
    480 https://doi.org/10.1186/s12864-015-1292-z
    481 rdf:type schema:CreativeWork
    482 sg:pub.10.1186/s13059-016-0879-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038383023
    483 https://doi.org/10.1186/s13059-016-0879-2
    484 rdf:type schema:CreativeWork
    485 sg:pub.10.1186/s13073-014-0066-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020107189
    486 https://doi.org/10.1186/s13073-014-0066-6
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1002/j.1460-2075.1989.tb03493.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1079303815
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.1016/0092-8674(89)90916-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002557623
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.1016/j.ccr.2010.10.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042891274
    493 rdf:type schema:CreativeWork
    494 https://doi.org/10.1016/j.ccr.2010.11.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010196923
    495 rdf:type schema:CreativeWork
    496 https://doi.org/10.1016/j.ccr.2013.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021552264
    497 rdf:type schema:CreativeWork
    498 https://doi.org/10.1016/j.cell.2005.10.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018757310
    499 rdf:type schema:CreativeWork
    500 https://doi.org/10.1016/j.cell.2011.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026115083
    501 rdf:type schema:CreativeWork
    502 https://doi.org/10.1016/j.cell.2012.12.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051880006
    503 rdf:type schema:CreativeWork
    504 https://doi.org/10.1016/j.cell.2013.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047212289
    505 rdf:type schema:CreativeWork
    506 https://doi.org/10.1016/j.cell.2013.03.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005302017
    507 rdf:type schema:CreativeWork
    508 https://doi.org/10.1016/j.cell.2013.03.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017590275
    509 rdf:type schema:CreativeWork
    510 https://doi.org/10.1016/j.cell.2013.07.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047377535
    511 rdf:type schema:CreativeWork
    512 https://doi.org/10.1016/j.cell.2013.09.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011111923
    513 rdf:type schema:CreativeWork
    514 https://doi.org/10.1016/j.cell.2014.09.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009620828
    515 rdf:type schema:CreativeWork
    516 https://doi.org/10.1016/j.cell.2014.10.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028872258
    517 rdf:type schema:CreativeWork
    518 https://doi.org/10.1016/j.cell.2015.11.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009674515
    519 rdf:type schema:CreativeWork
    520 https://doi.org/10.1016/j.celrep.2014.08.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002800972
    521 rdf:type schema:CreativeWork
    522 https://doi.org/10.1016/j.cub.2010.07.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030203445
    523 rdf:type schema:CreativeWork
    524 https://doi.org/10.1016/j.devcel.2010.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017676906
    525 rdf:type schema:CreativeWork
    526 https://doi.org/10.1016/j.gde.2010.03.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008714894
    527 rdf:type schema:CreativeWork
    528 https://doi.org/10.1016/j.gde.2014.03.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007490995
    529 rdf:type schema:CreativeWork
    530 https://doi.org/10.1016/j.molcel.2015.02.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030943729
    531 rdf:type schema:CreativeWork
    532 https://doi.org/10.1016/j.stem.2012.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017949272
    533 rdf:type schema:CreativeWork
    534 https://doi.org/10.1016/j.stem.2014.05.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049496085
    535 rdf:type schema:CreativeWork
    536 https://doi.org/10.1016/j.tibs.2014.02.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035488202
    537 rdf:type schema:CreativeWork
    538 https://doi.org/10.1016/j.tig.2012.02.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043221975
    539 rdf:type schema:CreativeWork
    540 https://doi.org/10.1016/j.tig.2014.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020150610
    541 rdf:type schema:CreativeWork
    542 https://doi.org/10.1016/j.tips.2013.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032986063
    543 rdf:type schema:CreativeWork
    544 https://doi.org/10.1016/j.ydbio.2010.05.493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009136530
    545 rdf:type schema:CreativeWork
    546 https://doi.org/10.1016/j.ymeth.2012.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027162735
    547 rdf:type schema:CreativeWork
    548 https://doi.org/10.1056/nejmra0803109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002500139
    549 rdf:type schema:CreativeWork
    550 https://doi.org/10.1056/nejmra0905980 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006094606
    551 rdf:type schema:CreativeWork
    552 https://doi.org/10.1073/pnas.012591199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021450538
    553 rdf:type schema:CreativeWork
    554 https://doi.org/10.1073/pnas.0307708100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047970186
    555 rdf:type schema:CreativeWork
    556 https://doi.org/10.1073/pnas.0903103106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020299353
    557 rdf:type schema:CreativeWork
    558 https://doi.org/10.1073/pnas.0910668107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029012444
    559 rdf:type schema:CreativeWork
    560 https://doi.org/10.1073/pnas.1016071107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047051560
    561 rdf:type schema:CreativeWork
    562 https://doi.org/10.1073/pnas.1506255112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018342866
    563 rdf:type schema:CreativeWork
    564 https://doi.org/10.1073/pnas.1508736112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044011711
    565 rdf:type schema:CreativeWork
    566 https://doi.org/10.1073/pnas.1519286113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044437485
    567 rdf:type schema:CreativeWork
    568 https://doi.org/10.1073/pnas.180316197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027811641
    569 rdf:type schema:CreativeWork
    570 https://doi.org/10.1073/pnas.79.24.7824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029478335
    571 rdf:type schema:CreativeWork
    572 https://doi.org/10.1073/pnas.79.24.7837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021868830
    573 rdf:type schema:CreativeWork
    574 https://doi.org/10.1073/pnas.80.3.820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029974447
    575 rdf:type schema:CreativeWork
    576 https://doi.org/10.1073/pnas.91.21.9700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018690110
    577 rdf:type schema:CreativeWork
    578 https://doi.org/10.1073/pnas.96.15.8681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014931389
    579 rdf:type schema:CreativeWork
    580 https://doi.org/10.1074/jbc.r113.512517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016089954
    581 rdf:type schema:CreativeWork
    582 https://doi.org/10.1093/emboj/17.6.1788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029574920
    583 rdf:type schema:CreativeWork
    584 https://doi.org/10.1093/hmg/ddg180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008338421
    585 rdf:type schema:CreativeWork
    586 https://doi.org/10.1093/jnci/92.7.564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044385773
    587 rdf:type schema:CreativeWork
    588 https://doi.org/10.1093/jnci/djn190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020895882
    589 rdf:type schema:CreativeWork
    590 https://doi.org/10.1093/nar/gkq929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005486377
    591 rdf:type schema:CreativeWork
    592 https://doi.org/10.1093/nar/gkt1229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047459836
    593 rdf:type schema:CreativeWork
    594 https://doi.org/10.1093/nar/gkv1530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005174154
    595 rdf:type schema:CreativeWork
    596 https://doi.org/10.1097/ppo.0b013e31823e5387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041563583
    597 rdf:type schema:CreativeWork
    598 https://doi.org/10.1101/gad.1272505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007710897
    599 rdf:type schema:CreativeWork
    600 https://doi.org/10.1101/gad.248526.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000495179
    601 rdf:type schema:CreativeWork
    602 https://doi.org/10.1101/gr.105361.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051822451
    603 rdf:type schema:CreativeWork
    604 https://doi.org/10.1101/gr.121541.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035192436
    605 rdf:type schema:CreativeWork
    606 https://doi.org/10.1101/gr.136127.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007044518
    607 rdf:type schema:CreativeWork
    608 https://doi.org/10.1101/gr.166231.113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007039701
    609 rdf:type schema:CreativeWork
    610 https://doi.org/10.1126/science.1217277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001335291
    611 rdf:type schema:CreativeWork
    612 https://doi.org/10.1126/science.1222794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017092582
    613 rdf:type schema:CreativeWork
    614 https://doi.org/10.1126/science.1228606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062467093
    615 rdf:type schema:CreativeWork
    616 https://doi.org/10.1126/science.1229259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062467132
    617 rdf:type schema:CreativeWork
    618 https://doi.org/10.1126/science.1230062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062467697
    619 rdf:type schema:CreativeWork
    620 https://doi.org/10.1126/science.1235122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035954369
    621 rdf:type schema:CreativeWork
    622 https://doi.org/10.1126/science.1259037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047749112
    623 rdf:type schema:CreativeWork
    624 https://doi.org/10.1126/science.6414084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062637543
    625 rdf:type schema:CreativeWork
    626 https://doi.org/10.1126/science.aad9024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028359583
    627 rdf:type schema:CreativeWork
    628 https://doi.org/10.1158/0008-5472.can-04-4313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001803874
    629 rdf:type schema:CreativeWork
    630 https://doi.org/10.1158/0008-5472.can-04-4608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077108311
    631 rdf:type schema:CreativeWork
    632 https://doi.org/10.1158/0008-5472.can-07-5766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039624768
    633 rdf:type schema:CreativeWork
    634 https://doi.org/10.1158/0008-5472.can-13-0789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042942258
    635 rdf:type schema:CreativeWork
    636 https://doi.org/10.1158/0008-5472.can-13-2498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023523845
    637 rdf:type schema:CreativeWork
    638 https://doi.org/10.1172/jci69738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050409805
    639 rdf:type schema:CreativeWork
    640 https://doi.org/10.1182/blood-2012-07-446120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049158420
    641 rdf:type schema:CreativeWork
    642 https://doi.org/10.1371/journal.pgen.1000597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041883716
    643 rdf:type schema:CreativeWork
    644 https://doi.org/10.1371/journal.pgen.1000888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022521320
    645 rdf:type schema:CreativeWork
    646 https://doi.org/10.1371/journal.pone.0012112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044407216
    647 rdf:type schema:CreativeWork
    648 https://doi.org/10.1371/journal.pone.0049160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051484867
    649 rdf:type schema:CreativeWork
    650 https://doi.org/10.1371/journal.pone.0092689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039289301
    651 rdf:type schema:CreativeWork
    652 https://doi.org/10.1371/journal.pone.0105393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038695422
    653 rdf:type schema:CreativeWork
    654 https://doi.org/10.1371/journal.pone.0111914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045630254
    655 rdf:type schema:CreativeWork
    656 https://doi.org/10.1371/journal.pone.0114485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041700241
    657 rdf:type schema:CreativeWork
    658 https://doi.org/10.5483/bmbrep.2014.47.6.092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007779597
    659 rdf:type schema:CreativeWork
    660 https://www.grid.ac/institutes/grid.4714.6 schema:alternateName Karolinska Institute
    661 schema:name Division of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, and Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm SE-171 77, Sweden.
    662 rdf:type schema:Organization
    663 https://www.grid.ac/institutes/grid.7737.4 schema:alternateName University of Helsinki
    664 schema:name Division of Functional Genomics and Systems Biology, Department of Medical Biochemistry and Biophysics, and Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm SE-171 77, Sweden.
    665 Genome-Scale Biology Program, University of Helsinki, Biomedicum, PO Box 63, Helsinki 00014, Finland.
    666 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...