Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-05

AUTHORS

Suzanne L. Topalian, Janis M. Taube, Robert A. Anders, Drew M. Pardoll

ABSTRACT

With recent approvals for multiple therapeutic antibodies that block cytotoxic T lymphocyte associated antigen 4 (CTLA4) and programmed cell death protein 1 (PD1) in melanoma, non-small-cell lung cancer and kidney cancer, and additional immune checkpoints being targeted clinically, many questions still remain regarding the optimal use of drugs that block these checkpoint pathways. Defining biomarkers that predict therapeutic effects and adverse events is a crucial mandate, highlighted by recent approvals for two PDL1 diagnostic tests. Here, we discuss biomarkers for anti-PD1 therapy based on immunological, genetic and virological criteria. The unique biology of the CTLA4 immune checkpoint, compared with PD1, requires a different approach to biomarker development. Mechanism-based insights from such studies may guide the design of synergistic treatment combinations based on immune checkpoint blockade. More... »

PAGES

275-287

References to SciGraph publications

  • 2012-07. An immune-active tumor microenvironment favors clinical response to ipilimumab in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2015-04. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer in NATURE
  • 2014-02. Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy in NATURE REVIEWS CANCER
  • 2002-08. Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion in NATURE MEDICINE
  • 2014-11. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients in NATURE
  • 2009-09. Lymphocyte recruitment into the tumor site is altered in patients with MSI-H colon cancer in FAMILIAL CANCER
  • 2015-04. The ins and outs of MHC class II-mediated antigen processing and presentation in NATURE REVIEWS IMMUNOLOGY
  • 2003-10. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase in NATURE MEDICINE
  • 1996-02. Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patients in NATURE MEDICINE
  • 2006-02. Restoring function in exhausted CD8 T cells during chronic viral infection in NATURE
  • 2014-01. Programmed death ligand-1 expression in non-small cell lung cancer in LABORATORY INVESTIGATION
  • 2015-02. Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25 in CELL RESEARCH
  • 2010-11-18. LAG-3 in Cancer Immunotherapy in CANCER IMMUNOLOGY AND IMMUNOTHERAPY
  • 2012-04. The blockade of immune checkpoints in cancer immunotherapy in NATURE REVIEWS CANCER
  • 2014-11. PD-1 blockade induces responses by inhibiting adaptive immune resistance in NATURE
  • 2007-01. Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma in NATURE MEDICINE
  • 1999-12. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion in NATURE MEDICINE
  • 2015-08. Evolving synergistic combinations of targeted immunotherapies to combat cancer in NATURE REVIEWS CANCER
  • 2014-11. Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing in NATURE
  • 2005-12. Human T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL) in RETROVIROLOGY
  • 2012-04. The immune contexture in human tumours: impact on clinical outcome in NATURE REVIEWS CANCER
  • 2013-07. Mutational heterogeneity in cancer and the search for new cancer-associated genes in NATURE
  • 2014-11. Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc.2016.36

    DOI

    http://dx.doi.org/10.1038/nrc.2016.36

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1012106897

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27079802


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    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrc.2016.36'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrc.2016.36'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrc.2016.36'


     

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