Notch as a tumour suppressor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-02-03

AUTHORS

Craig S. Nowell, Freddy Radtke

ABSTRACT

Key PointsNotch signalling can be either oncogenic or tumour suppressive depending on the tissue and/or cellular context.Notch signalling is tumour suppressive for various solid tumours, including squamous cell carcinoma in several epithelial tissues, subtypes of brain cancer, liver cancer and small-cell lung cancer.Loss of Notch signalling can result in perturbed regulation of cell fate decisions in stem and progenitor cells, resulting in tumour development.Loss of Notch signalling can also lead to stromal remodelling and the generation of a pro-tumorigenic microenvironment that promotes carcinogenesis. More... »

PAGES

145-159

References to SciGraph publications

  • 2015-04-13. Mutational landscape and clonal architecture in grade II and III gliomas in NATURE GENETICS
  • 2015-07-13. Comprehensive genomic profiles of small cell lung cancer in NATURE
  • 2008-07-01. Cancer-related inflammation in NATURE
  • 2014-05-11. Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change in NATURE CELL BIOLOGY
  • 2011-05-11. A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia in NATURE
  • 1995-03. Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor in NATURE
  • 2003-11. AP-1: a double-edged sword in tumorigenesis in NATURE REVIEWS CANCER
  • 2007-04-01. Structural basis for autoinhibition of Notch in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2015-12-21. Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction in NATURE CELL BIOLOGY
  • 2007-08-11. Notch and cancer: a double-edged sword in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2014-09-07. A new tumor suppressor role for the Notch pathway in bladder cancer in NATURE MEDICINE
  • 2010-10-01. Alzheimer's failure raises questions about disease-modifying strategies in NATURE REVIEWS DRUG DISCOVERY
  • 2014-01-29. Comprehensive molecular characterization of urothelial bladder carcinoma in NATURE
  • 2011-09-18. Dll4-Notch signaling as a therapeutic target in tumor angiogenesis in VASCULAR CELL
  • 2015-08-10. Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth in NATURE CELL BIOLOGY
  • 2009-02-11. Epidermal homeostasis: a balancing act of stem cells in the skin in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2014-01-15. Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts in NATURE
  • 2015-04-17. Acute promyelocytic leukemia: where did we start, where are we now, and the future in BLOOD CANCER JOURNAL
  • 2013-08-12. The pathological significance of Notch1 in oral squamous cell carcinoma in LABORATORY INVESTIGATION
  • 2007-11-08. JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 2009-02. The different faces of Notch in T-helper-cell differentiation in NATURE REVIEWS IMMUNOLOGY
  • 2009-09-22. The oncogenic roles of Notch1 in astrocytic gliomas in vitro and in vivo in JOURNAL OF NEURO-ONCOLOGY
  • 2011-11-20. Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer in NATURE MEDICINE
  • 2014-08-24. Genetic landscape of esophageal squamous cell carcinoma in NATURE GENETICS
  • 2006-09. Notch signalling: a simple pathway becomes complex in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2003-12. The role of Notch in tumorigenesis: oncogene or tumour suppressor? in NATURE REVIEWS CANCER
  • 2009-07-16. Crosstalk of Notch with p53 and p63 in cancer growth control in NATURE REVIEWS CANCER
  • 2016-04-25. NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell in SCIENTIFIC REPORTS
  • 2012-06-01. The Role of Notch in the Differentiation of CD4+ T Helper Cells in NOTCH REGULATION OF THE IMMUNE SYSTEM
  • 2012. Notch Signaling and Breast Cancer in NOTCH SIGNALING IN EMBRYOLOGY AND CANCER
  • 2008-07-06. EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer in NATURE CELL BIOLOGY
  • 2003-02-18. Notch1 functions as a tumor suppressor in mouse skin in NATURE GENETICS
  • 2002-12. Inflammation and cancer in NATURE
  • 2009-08-27. Multi-stage chemical carcinogenesis in mouse skin: Fundamentals and applications in NATURE PROTOCOLS
  • 2015-07-13. Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma in NATURE MEDICINE
  • 2014-01-14. Hesperetin Activates the Notch1 Signaling Cascade, Causes Apoptosis, and Induces Cellular Differentiation in Anaplastic Thyroid Cancer in ANNALS OF SURGICAL ONCOLOGY
  • 2014-07-19. Expression pattern of Notch intracellular domain (NICD) and Hes-1 in preneoplastic and neoplastic human oral squamous epithelium: their correlation with c-Myc, clinicopathological factors and prognosis in Oral cancer in MEDICAL ONCOLOGY
  • 2014-03-16. Identification of genomic alterations in oesophageal squamous cell cancer in NATURE
  • 2011-06-05. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia in NATURE
  • 2004-11-15. Molecular mechanisms for morphogenesis of the central nervous system in mammals* in ANATOMICAL SCIENCE INTERNATIONAL
  • 2011-04-14. Notch signalling in solid tumours: a little bit of everything but not all the time in NATURE REVIEWS CANCER
  • 2004-11. Identification of human brain tumour initiating cells in NATURE
  • 2010-04. Therapeutic antibody targeting of individual Notch receptors in NATURE
  • 2002-09-01. γ-Secretase-mediated proteolysis in cell-surface-receptor signalling in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2006-12. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc.2016.145

    DOI

    http://dx.doi.org/10.1038/nrc.2016.145

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1083524259

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28154375


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Differentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Notch", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Suppressor Proteins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department for Pathology and Immunology, CMU, University of Geneva, Rue Michel Servet, 1211, Geneva 4, Switzerland", 
              "id": "http://www.grid.ac/institutes/grid.8591.5", 
              "name": [
                "Department for Pathology and Immunology, CMU, University of Geneva, Rue Michel Servet, 1211, Geneva 4, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nowell", 
            "givenName": "Craig S.", 
            "id": "sg:person.011661701333.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011661701333.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, School of Life Sciences, Swiss Institute for Experimental Cancer Research, 1015, Lausanne, Vaud, Switzerland", 
              "id": "http://www.grid.ac/institutes/grid.5333.6", 
              "name": [
                "Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, School of Life Sciences, Swiss Institute for Experimental Cancer Research, 1015, Lausanne, Vaud, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Radtke", 
            "givenName": "Freddy", 
            "id": "sg:person.01021176505.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021176505.96"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s10549-007-9805-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008801485", 
              "https://doi.org/10.1007/s10549-007-9805-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05313", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034553835", 
              "https://doi.org/10.1038/nature05313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029451229", 
              "https://doi.org/10.1038/ng.3076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bcj.2015.25", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026899959", 
              "https://doi.org/10.1038/bcj.2015.25"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb1750", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044811434", 
              "https://doi.org/10.1038/ncb1750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08878", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026135489", 
              "https://doi.org/10.1038/nature08878"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047048748", 
              "https://doi.org/10.1038/nrc3035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2488", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016454220", 
              "https://doi.org/10.1038/nri2488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-007-7164-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040206583", 
              "https://doi.org/10.1007/s00018-007-7164-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb3290", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011115626", 
              "https://doi.org/10.1038/ncb3290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019849472", 
              "https://doi.org/10.1038/nrm2009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032662846", 
              "https://doi.org/10.1038/nature13176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2963", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008960303", 
              "https://doi.org/10.1038/ncb2963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3678", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013803017", 
              "https://doi.org/10.1038/nm.3678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12965", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032218108", 
              "https://doi.org/10.1038/nature12965"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb3216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022417218", 
              "https://doi.org/10.1038/ncb3216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3273", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007363870", 
              "https://doi.org/10.1038/ng.3273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/labinvest.2013.95", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013693901", 
              "https://doi.org/10.1038/labinvest.2013.95"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11060-009-0007-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033125485", 
              "https://doi.org/10.1007/s11060-009-0007-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd3288", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003812242", 
              "https://doi.org/10.1038/nrd3288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/2045-824x-3-20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003764073", 
              "https://doi.org/10.1186/2045-824x-3-20"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2636", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023434470", 
              "https://doi.org/10.1038/nrm2636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008698030", 
              "https://doi.org/10.1038/nature10113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2009.120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033240866", 
              "https://doi.org/10.1038/nprot.2009.120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019336134", 
              "https://doi.org/10.1038/nature01322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12032-014-0126-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041672786", 
              "https://doi.org/10.1007/s12032-014-0126-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/374159a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000456538", 
              "https://doi.org/10.1038/374159a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/82_2012_227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030415970", 
              "https://doi.org/10.1007/82_2012_227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14664", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050825100", 
              "https://doi.org/10.1038/nature14664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep24704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036565272", 
              "https://doi.org/10.1038/srep24704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041697410", 
              "https://doi.org/10.1038/ng1099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12883", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016677250", 
              "https://doi.org/10.1038/nature12883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3878", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045622343", 
              "https://doi.org/10.1038/nm.3878"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4614-0899-4_18", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018318765", 
              "https://doi.org/10.1007/978-1-4614-0899-4_18"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm910", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022437937", 
              "https://doi.org/10.1038/nrm910"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024729982", 
              "https://doi.org/10.1038/nature07205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-013-3459-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015031881", 
              "https://doi.org/10.1245/s10434-013-3459-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09999", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018883613", 
              "https://doi.org/10.1038/nature09999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1186", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004707046", 
              "https://doi.org/10.1038/nrc1186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1447-073x.2004.00085.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037653712", 
              "https://doi.org/10.1111/j.1447-073x.2004.00085.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2675", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036162331", 
              "https://doi.org/10.1038/nrc2675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2580", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035286718", 
              "https://doi.org/10.1038/nm.2580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008405783", 
              "https://doi.org/10.1038/nrc1209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027226854", 
              "https://doi.org/10.1038/nature03128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb1227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014955709", 
              "https://doi.org/10.1038/nsmb1227"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-02-03", 
        "datePublishedReg": "2017-02-03", 
        "description": "Key PointsNotch signalling can be either oncogenic or tumour suppressive depending on the tissue and/or cellular context.Notch signalling is tumour suppressive for various solid tumours, including squamous cell carcinoma in several epithelial tissues, subtypes of brain cancer, liver cancer and small-cell lung cancer.Loss of Notch signalling can result in perturbed regulation of cell fate decisions in stem and progenitor cells, resulting in tumour development.Loss of Notch signalling can also lead to stromal remodelling and the generation of a pro-tumorigenic microenvironment that promotes carcinogenesis.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/nrc.2016.145", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1029716", 
            "issn": [
              "1474-175X", 
              "1474-1768"
            ], 
            "name": "Nature Reviews Cancer", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "17"
          }
        ], 
        "keywords": [
          "small cell lung cancer", 
          "squamous cell carcinoma", 
          "pro-tumorigenic microenvironment", 
          "Notch signaling", 
          "tumor suppressive depending", 
          "cell carcinoma", 
          "lung cancer", 
          "liver cancer", 
          "stromal remodelling", 
          "brain cancer", 
          "solid tumors", 
          "tumor development", 
          "progenitor cells", 
          "cancer", 
          "tumors", 
          "tumor suppressor", 
          "epithelial tissues", 
          "perturbed regulation", 
          "signaling", 
          "tissue", 
          "carcinoma", 
          "subtypes", 
          "carcinogenesis", 
          "remodelling", 
          "microenvironment", 
          "cellular context", 
          "loss", 
          "cells", 
          "cell fate decisions", 
          "suppressor", 
          "fate decisions", 
          "regulation", 
          "Notch", 
          "development", 
          "stem", 
          "decisions", 
          "depending", 
          "generation", 
          "context"
        ], 
        "name": "Notch as a tumour suppressor", 
        "pagination": "145-159", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1083524259"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nrc.2016.145"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28154375"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nrc.2016.145", 
          "https://app.dimensions.ai/details/publication/pub.1083524259"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-11-24T21:01", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_718.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/nrc.2016.145"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nrc.2016.145'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nrc.2016.145'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nrc.2016.145'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nrc.2016.145'


     

    This table displays all metadata directly associated to this object as RDF triples.

    318 TRIPLES      21 PREDICATES      116 URIs      63 LITERALS      14 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nrc.2016.145 schema:about N0ba21105b5df4aacad3ee2b613b439aa
    2 N7a4fd74bdae1438c9865fc6cb8e1fddc
    3 N90872132b960429ea9325b8d35996533
    4 N928558cd067d4b3cbcd7d2f5ac3ec6f9
    5 N93cda5d22c864c6088c4b5dfc6f1e966
    6 Need97503ee0340c894c059e1aee07bd1
    7 Nf614522b5a6b40c5bea33e06740f1ffc
    8 anzsrc-for:11
    9 anzsrc-for:1112
    10 schema:author Nf0482bb693c44bfbb28a958cdc8ea6a2
    11 schema:citation sg:pub.10.1007/82_2012_227
    12 sg:pub.10.1007/978-1-4614-0899-4_18
    13 sg:pub.10.1007/s00018-007-7164-1
    14 sg:pub.10.1007/s10549-007-9805-3
    15 sg:pub.10.1007/s11060-009-0007-1
    16 sg:pub.10.1007/s12032-014-0126-1
    17 sg:pub.10.1038/374159a0
    18 sg:pub.10.1038/bcj.2015.25
    19 sg:pub.10.1038/labinvest.2013.95
    20 sg:pub.10.1038/nature01322
    21 sg:pub.10.1038/nature03128
    22 sg:pub.10.1038/nature05313
    23 sg:pub.10.1038/nature07205
    24 sg:pub.10.1038/nature08878
    25 sg:pub.10.1038/nature09999
    26 sg:pub.10.1038/nature10113
    27 sg:pub.10.1038/nature12883
    28 sg:pub.10.1038/nature12965
    29 sg:pub.10.1038/nature13176
    30 sg:pub.10.1038/nature14664
    31 sg:pub.10.1038/ncb1750
    32 sg:pub.10.1038/ncb2963
    33 sg:pub.10.1038/ncb3216
    34 sg:pub.10.1038/ncb3290
    35 sg:pub.10.1038/ng.3076
    36 sg:pub.10.1038/ng.3273
    37 sg:pub.10.1038/ng1099
    38 sg:pub.10.1038/nm.2580
    39 sg:pub.10.1038/nm.3678
    40 sg:pub.10.1038/nm.3878
    41 sg:pub.10.1038/nprot.2009.120
    42 sg:pub.10.1038/nrc1186
    43 sg:pub.10.1038/nrc1209
    44 sg:pub.10.1038/nrc2675
    45 sg:pub.10.1038/nrc3035
    46 sg:pub.10.1038/nrd3288
    47 sg:pub.10.1038/nri2488
    48 sg:pub.10.1038/nrm2009
    49 sg:pub.10.1038/nrm2636
    50 sg:pub.10.1038/nrm910
    51 sg:pub.10.1038/nsmb1227
    52 sg:pub.10.1038/srep24704
    53 sg:pub.10.1111/j.1447-073x.2004.00085.x
    54 sg:pub.10.1186/2045-824x-3-20
    55 sg:pub.10.1245/s10434-013-3459-7
    56 schema:datePublished 2017-02-03
    57 schema:datePublishedReg 2017-02-03
    58 schema:description Key PointsNotch signalling can be either oncogenic or tumour suppressive depending on the tissue and/or cellular context.Notch signalling is tumour suppressive for various solid tumours, including squamous cell carcinoma in several epithelial tissues, subtypes of brain cancer, liver cancer and small-cell lung cancer.Loss of Notch signalling can result in perturbed regulation of cell fate decisions in stem and progenitor cells, resulting in tumour development.Loss of Notch signalling can also lead to stromal remodelling and the generation of a pro-tumorigenic microenvironment that promotes carcinogenesis.
    59 schema:genre article
    60 schema:isAccessibleForFree false
    61 schema:isPartOf N5c998a099d2b471fb0dedd0d067a03ee
    62 Nff02e60f3d154a6e8f0d4c0b0932af5b
    63 sg:journal.1029716
    64 schema:keywords Notch
    65 Notch signaling
    66 brain cancer
    67 cancer
    68 carcinogenesis
    69 carcinoma
    70 cell carcinoma
    71 cell fate decisions
    72 cells
    73 cellular context
    74 context
    75 decisions
    76 depending
    77 development
    78 epithelial tissues
    79 fate decisions
    80 generation
    81 liver cancer
    82 loss
    83 lung cancer
    84 microenvironment
    85 perturbed regulation
    86 pro-tumorigenic microenvironment
    87 progenitor cells
    88 regulation
    89 remodelling
    90 signaling
    91 small cell lung cancer
    92 solid tumors
    93 squamous cell carcinoma
    94 stem
    95 stromal remodelling
    96 subtypes
    97 suppressor
    98 tissue
    99 tumor development
    100 tumor suppressive depending
    101 tumor suppressor
    102 tumors
    103 schema:name Notch as a tumour suppressor
    104 schema:pagination 145-159
    105 schema:productId N6267f3f6ad964acf8a62ffe9c3d96fe1
    106 N6b91ae1bc43e40c8b3c4c12ec1edfa46
    107 N7df27ba195ae4e42be5bbec3d88e4a3a
    108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083524259
    109 https://doi.org/10.1038/nrc.2016.145
    110 schema:sdDatePublished 2022-11-24T21:01
    111 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    112 schema:sdPublisher N1ce4bad54f424b37a939decea62cd789
    113 schema:url https://doi.org/10.1038/nrc.2016.145
    114 sgo:license sg:explorer/license/
    115 sgo:sdDataset articles
    116 rdf:type schema:ScholarlyArticle
    117 N0ba21105b5df4aacad3ee2b613b439aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Animals
    119 rdf:type schema:DefinedTerm
    120 N1ce4bad54f424b37a939decea62cd789 schema:name Springer Nature - SN SciGraph project
    121 rdf:type schema:Organization
    122 N55706d6cb46945948aa96e15fd846e9a rdf:first sg:person.01021176505.96
    123 rdf:rest rdf:nil
    124 N5c998a099d2b471fb0dedd0d067a03ee schema:issueNumber 3
    125 rdf:type schema:PublicationIssue
    126 N6267f3f6ad964acf8a62ffe9c3d96fe1 schema:name dimensions_id
    127 schema:value pub.1083524259
    128 rdf:type schema:PropertyValue
    129 N6b91ae1bc43e40c8b3c4c12ec1edfa46 schema:name doi
    130 schema:value 10.1038/nrc.2016.145
    131 rdf:type schema:PropertyValue
    132 N7a4fd74bdae1438c9865fc6cb8e1fddc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Signal Transduction
    134 rdf:type schema:DefinedTerm
    135 N7df27ba195ae4e42be5bbec3d88e4a3a schema:name pubmed_id
    136 schema:value 28154375
    137 rdf:type schema:PropertyValue
    138 N90872132b960429ea9325b8d35996533 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Cell Differentiation
    140 rdf:type schema:DefinedTerm
    141 N928558cd067d4b3cbcd7d2f5ac3ec6f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Neoplasms
    143 rdf:type schema:DefinedTerm
    144 N93cda5d22c864c6088c4b5dfc6f1e966 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Humans
    146 rdf:type schema:DefinedTerm
    147 Need97503ee0340c894c059e1aee07bd1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Tumor Suppressor Proteins
    149 rdf:type schema:DefinedTerm
    150 Nf0482bb693c44bfbb28a958cdc8ea6a2 rdf:first sg:person.011661701333.82
    151 rdf:rest N55706d6cb46945948aa96e15fd846e9a
    152 Nf614522b5a6b40c5bea33e06740f1ffc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Receptors, Notch
    154 rdf:type schema:DefinedTerm
    155 Nff02e60f3d154a6e8f0d4c0b0932af5b schema:volumeNumber 17
    156 rdf:type schema:PublicationVolume
    157 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    158 schema:name Medical and Health Sciences
    159 rdf:type schema:DefinedTerm
    160 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    161 schema:name Oncology and Carcinogenesis
    162 rdf:type schema:DefinedTerm
    163 sg:journal.1029716 schema:issn 1474-175X
    164 1474-1768
    165 schema:name Nature Reviews Cancer
    166 schema:publisher Springer Nature
    167 rdf:type schema:Periodical
    168 sg:person.01021176505.96 schema:affiliation grid-institutes:grid.5333.6
    169 schema:familyName Radtke
    170 schema:givenName Freddy
    171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021176505.96
    172 rdf:type schema:Person
    173 sg:person.011661701333.82 schema:affiliation grid-institutes:grid.8591.5
    174 schema:familyName Nowell
    175 schema:givenName Craig S.
    176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011661701333.82
    177 rdf:type schema:Person
    178 sg:pub.10.1007/82_2012_227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030415970
    179 https://doi.org/10.1007/82_2012_227
    180 rdf:type schema:CreativeWork
    181 sg:pub.10.1007/978-1-4614-0899-4_18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018318765
    182 https://doi.org/10.1007/978-1-4614-0899-4_18
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1007/s00018-007-7164-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040206583
    185 https://doi.org/10.1007/s00018-007-7164-1
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1007/s10549-007-9805-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008801485
    188 https://doi.org/10.1007/s10549-007-9805-3
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1007/s11060-009-0007-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033125485
    191 https://doi.org/10.1007/s11060-009-0007-1
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1007/s12032-014-0126-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041672786
    194 https://doi.org/10.1007/s12032-014-0126-1
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/374159a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000456538
    197 https://doi.org/10.1038/374159a0
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/bcj.2015.25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026899959
    200 https://doi.org/10.1038/bcj.2015.25
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/labinvest.2013.95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013693901
    203 https://doi.org/10.1038/labinvest.2013.95
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/nature01322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019336134
    206 https://doi.org/10.1038/nature01322
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/nature03128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027226854
    209 https://doi.org/10.1038/nature03128
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/nature05313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034553835
    212 https://doi.org/10.1038/nature05313
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/nature07205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024729982
    215 https://doi.org/10.1038/nature07205
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/nature08878 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026135489
    218 https://doi.org/10.1038/nature08878
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/nature09999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018883613
    221 https://doi.org/10.1038/nature09999
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1038/nature10113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008698030
    224 https://doi.org/10.1038/nature10113
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/nature12883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016677250
    227 https://doi.org/10.1038/nature12883
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/nature12965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032218108
    230 https://doi.org/10.1038/nature12965
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/nature13176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032662846
    233 https://doi.org/10.1038/nature13176
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/nature14664 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050825100
    236 https://doi.org/10.1038/nature14664
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/ncb1750 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044811434
    239 https://doi.org/10.1038/ncb1750
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/ncb2963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008960303
    242 https://doi.org/10.1038/ncb2963
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/ncb3216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022417218
    245 https://doi.org/10.1038/ncb3216
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/ncb3290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011115626
    248 https://doi.org/10.1038/ncb3290
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/ng.3076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029451229
    251 https://doi.org/10.1038/ng.3076
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/ng.3273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007363870
    254 https://doi.org/10.1038/ng.3273
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/ng1099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041697410
    257 https://doi.org/10.1038/ng1099
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/nm.2580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035286718
    260 https://doi.org/10.1038/nm.2580
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/nm.3678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013803017
    263 https://doi.org/10.1038/nm.3678
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/nm.3878 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045622343
    266 https://doi.org/10.1038/nm.3878
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/nprot.2009.120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033240866
    269 https://doi.org/10.1038/nprot.2009.120
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/nrc1186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004707046
    272 https://doi.org/10.1038/nrc1186
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/nrc1209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008405783
    275 https://doi.org/10.1038/nrc1209
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1038/nrc2675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036162331
    278 https://doi.org/10.1038/nrc2675
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/nrc3035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047048748
    281 https://doi.org/10.1038/nrc3035
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/nrd3288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003812242
    284 https://doi.org/10.1038/nrd3288
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1038/nri2488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016454220
    287 https://doi.org/10.1038/nri2488
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1038/nrm2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019849472
    290 https://doi.org/10.1038/nrm2009
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1038/nrm2636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023434470
    293 https://doi.org/10.1038/nrm2636
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1038/nrm910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022437937
    296 https://doi.org/10.1038/nrm910
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1038/nsmb1227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014955709
    299 https://doi.org/10.1038/nsmb1227
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1038/srep24704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036565272
    302 https://doi.org/10.1038/srep24704
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1111/j.1447-073x.2004.00085.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037653712
    305 https://doi.org/10.1111/j.1447-073x.2004.00085.x
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1186/2045-824x-3-20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003764073
    308 https://doi.org/10.1186/2045-824x-3-20
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1245/s10434-013-3459-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015031881
    311 https://doi.org/10.1245/s10434-013-3459-7
    312 rdf:type schema:CreativeWork
    313 grid-institutes:grid.5333.6 schema:alternateName Ecole Polytechnique Fédérale de Lausanne, School of Life Sciences, Swiss Institute for Experimental Cancer Research, 1015, Lausanne, Vaud, Switzerland
    314 schema:name Ecole Polytechnique Fédérale de Lausanne, School of Life Sciences, Swiss Institute for Experimental Cancer Research, 1015, Lausanne, Vaud, Switzerland
    315 rdf:type schema:Organization
    316 grid-institutes:grid.8591.5 schema:alternateName Department for Pathology and Immunology, CMU, University of Geneva, Rue Michel Servet, 1211, Geneva 4, Switzerland
    317 schema:name Department for Pathology and Immunology, CMU, University of Geneva, Rue Michel Servet, 1211, Geneva 4, Switzerland
    318 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...