Antitumour actions of interferons: implications for cancer therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-03

AUTHORS

Belinda S. Parker, Jai Rautela, Paul J. Hertzog

ABSTRACT

The interferons (IFNs) are a family of cytokines that protect against disease by direct effects on target cells and by activating immune responses. The production and actions of IFNs are finely tuned to achieve maximal protection and avoid the potential toxicity associated with excessive responses. IFNs are back in the spotlight owing to mounting evidence that is reshaping how we can exploit this pathway therapeutically. As IFNs can be produced by, and act on, both tumour cells and immune cells, understanding this reciprocal interaction will enable the development of improved single-agent or combination therapies that exploit IFN pathways and new 'omics'-based biomarkers to indicate responsive patients. More... »

PAGES

131-144

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nrc.2016.14

    DOI

    http://dx.doi.org/10.1038/nrc.2016.14

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052569474

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26911188


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