Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-07

AUTHORS

Prateek Kumar, Steven Henikoff, Pauline C Ng

ABSTRACT

The effect of genetic mutation on phenotype is of significant interest in genetics. The type of genetic mutation that causes a single amino acid substitution (AAS) in a protein sequence is called a non-synonymous single nucleotide polymorphism (nsSNP). An nsSNP could potentially affect the function of the protein, subsequently altering the carrier's phenotype. This protocol describes the use of the 'Sorting Tolerant From Intolerant' (SIFT) algorithm in predicting whether an AAS affects protein function. To assess the effect of a substitution, SIFT assumes that important positions in a protein sequence have been conserved throughout evolution and therefore substitutions at these positions may affect protein function. Thus, by using sequence homology, SIFT predicts the effects of all possible substitutions at each position in the protein sequence. The protocol typically takes 5-20 min, depending on the input. SIFT is available as an online tool (http://sift.jcvi.org). More... »

PAGES

1073-1081

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nprot.2009.86

DOI

http://dx.doi.org/10.1038/nprot.2009.86

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015642657

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19561590


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