A C. elegans-based, whole animal, in vivo screen for the identification of antifungal compounds View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-12

AUTHORS

Emmanouil Tampakakis, Ikechukwu Okoli, Eleftherios Mylonakis

ABSTRACT

Traditional antimicrobial screens focus on compounds that block the growth of microbial organisms. A new Caenorhabditis elegans-based bioassay can be used for the identification of antifungal compounds that are effective against Candida albicans. According to the protocol, adult nematodes are infected with C. albicans and moved to 96-well plates containing the tested compounds. In the presence of compounds with no antifungal activity, the fungus kills the worms and develops filaments that penetrate through the cuticle. In contrast to traditional screening methods and mammalian models, this facile, time-efficient and less costly assay allows the study of Candida cells in nonplanktonic form and may allow the concurrent evaluation of toxicity and antifungal activity and identify compounds that target virulence factors or modify host immune response. The screening assay takes about 5-6 d depending on the experimental design. More... »

PAGES

1925-1931

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nprot.2008.193

DOI

http://dx.doi.org/10.1038/nprot.2008.193

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025766788

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19180076


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