Social Learning Requires Plasticity Enhanced by Fluoxetine Through Prefrontal Bdnf-TrkB Signaling to Limit Aggression Induced by Post-Weaning Social Isolation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-01

AUTHORS

Éva Mikics, Ramon Guirado, Juzoh Umemori, Máté Tóth, László Biró, Christina Miskolczi, Diána Balázsfi, Dóra Zelena, Eero Castrén, József Haller, Nina N Karpova

ABSTRACT

Escalated or abnormal aggression induced by early adverse experiences is a growing issue of social concern and urges the development of effective treatment strategies. Here we report that synergistic interactions between psychosocial and biological factors specifically ameliorate escalated aggression induced by early adverse experiences. Rats reared in isolation from weaning until early adulthood showed abnormal forms of aggression and social deficits that were temporarily ameliorated by re-socialization, but aggression again escalated in a novel environment. We demonstrate that when re-socialization was combined with the antidepressant fluoxetine, which has been shown to reactivate juvenile-like state of plasticity, escalated aggression was greatly attenuated, while neither treatment alone was effective. Early isolation induced a permanent, re-socialization-resistant reduction in Bdnf expression in the amygdala and the infralimbic cortex. Only the combined treatment of fluoxetine and re-socialization was able to recover Bdnf expression via epigenetic regulation. Moreover, the behavior improvement after the combined treatment was dependent on TrkB activity. Combined treatment specifically strengthened the input from the ventral hippocampus to the mPFC, suggesting that this pathway is an important mediator of the beneficial behavioral effects of the combined psychosocial and pharmacological treatment of abnormal aggression. Our findings suggest that synergy between pharmacological induction of plasticity and psychosocial rehabilitation could enhance the efficacy of therapies for pathological aggression. More... »

PAGES

235

References to SciGraph publications

  • 2014-08. Hippocampal–Prefrontal BDNF and Memory for Fear Extinction in NEUROPSYCHOPHARMACOLOGY
  • 2013-04. Excessive aggression as model of violence: a critical evaluation of current preclinical methods in PSYCHOPHARMACOLOGY
  • 2016-09. Activation of a ventral hippocampus–medial prefrontal cortex pathway is both necessary and sufficient for an antidepressant response to ketamine in MOLECULAR PSYCHIATRY
  • 2016-07. Functional Role of BDNF Production from Unique Promoters in Aggression and Serotonin Signaling in NEUROPSYCHOPHARMACOLOGY
  • 2015-11. Basomedial amygdala mediates top-down control of anxiety and fear in NATURE
  • 2013-07. Early Social Experience Is Critical for the Development of Cognitive Control and Dopamine Modulation of Prefrontal Cortex Function in NEUROPSYCHOPHARMACOLOGY
  • 1996-02. The Influence of Fluoxetine on Aggressive Behavior in NEUROPSYCHOPHARMACOLOGY
  • 2015-05. Stress and the social brain: behavioural effects and neurobiological mechanisms in NATURE REVIEWS NEUROSCIENCE
  • 2009-08. The effect of increased serotonergic neurotransmission on aggression: a critical meta-analytical review of preclinical studies in PSYCHOPHARMACOLOGY
  • 2015-06. Hippocampal–prefrontal input supports spatial encoding in working memory in NATURE
  • 2014-04. Disrupted social development enhances the motivation for cocaine in rats in PSYCHOPHARMACOLOGY
  • 2013-01. Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression in TRANSLATIONAL PSYCHIATRY
  • 2014-03. Methylation of the promoter of brain-derived neurotrophic factor exon IV and antidepressant response in major depression in MOLECULAR PSYCHIATRY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/npp.2017.142

    DOI

    http://dx.doi.org/10.1038/npp.2017.142

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1090377947

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28685757


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