Generalization of Extinguished Fear to Untreated Fear Stimuli after Exposure View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Friederike Preusser, Jürgen Margraf, Armin Zlomuzica

ABSTRACT

Exposure therapy is highly effective in treating excessive fear related to specific objects and/or situations. However, patients with anxiety disorders often display a generalization of fear responses toward conceptually and perceptually related stimuli and situations. It is unclear whether the beneficial effects of exposure on fear reduction toward treated fear stimuli can extend to untreated fear stimuli. Here, we investigated whether basic principles of extinction generalization apply to exposure. Spider-phobic participants were randomly assigned to either two sessions of exposure treatment (n=23) with spiders or no-treatment (n=24). Prior to and after treatment, behavioral approach tests (BATs) were conducted to examine avoidance, fear and disgust responses toward the treated phobic stimulus (spider as the extinction stimulus). Likewise, BATs with the untreated fear stimulus (cockroach) were conducted to dissect the generalization of treatment effects. Treatment was highly effective in increasing approach behavior toward both treated and untreated fear stimuli. Generalization of treatment effects were evident on the behavioral (approach distance during the BAT), subjective (fear levels during the BAT) and psychophysiological level (heart rate during the BAT). However, a stronger decline in disgust was only evident for the treated fear stimulus. Notably, the herein attained generalization effects were not context-dependent. Hence, exposure therapy for spider phobia was effective in reducing fear of untreated stimuli which share common fear-evoking characteristics with spiders but were never presented during the respective exposure treatment. These findings provide clinical evidence for extinction generalization across different fear-evoking stimuli mediated via exposure. More... »

PAGES

2545

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/npp.2017.119

DOI

http://dx.doi.org/10.1038/npp.2017.119

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085913966

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28589965


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1701", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Psychology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/17", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Psychology and Cognitive Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Analysis of Variance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Choice Behavior", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cockroaches", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Extinction, Psychological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fear", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Generalization (Psychology)", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Implosive Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuropsychological Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phobic Disorders", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spiders", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Ruhr University Bochum", 
          "id": "https://www.grid.ac/institutes/grid.5570.7", 
          "name": [
            "Mental Health Research and Treatment Center, Ruhr-University Bochum, Bochum, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Preusser", 
        "givenName": "Friederike", 
        "id": "sg:person.0737126063.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737126063.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ruhr University Bochum", 
          "id": "https://www.grid.ac/institutes/grid.5570.7", 
          "name": [
            "Mental Health Research and Treatment Center, Ruhr-University Bochum, Bochum, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Margraf", 
        "givenName": "J\u00fcrgen", 
        "id": "sg:person.015050023035.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015050023035.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ruhr University Bochum", 
          "id": "https://www.grid.ac/institutes/grid.5570.7", 
          "name": [
            "Mental Health Research and Treatment Center, Ruhr-University Bochum, Bochum, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zlomuzica", 
        "givenName": "Armin", 
        "id": "sg:person.0756263333.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756263333.73"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1371/journal.pone.0096569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001661783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0096569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001661783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/02699930441000300", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002373546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.beth.2014.10.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005724095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tics.2014.12.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005769758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpsychires.2012.04.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009938999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0005-7967(98)00106-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012531786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0956797614535401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014115188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0956797614535401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014115188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0005-7967(97)10017-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014554267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brat.2007.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017064399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2015.04.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020900036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.janxdis.2006.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026668177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000050322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031052605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brat.2014.04.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031124168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1192/bjp.bp.106.032631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032585061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0887-6185(01)00089-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035512174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000050321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035991814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/0022-006x.67.4.599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036259444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/da.22356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037825027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/clipsy.7.3.291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037833506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/clipsy.7.3.291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037833506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1037/a0018916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039284942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0887-6185(02)00173-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041347515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.nmd.0000253843.70149.9a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044396558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.nmd.0000253843.70149.9a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044396558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0005-7967(01)00094-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045748817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0005-7967(09)80011-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045937036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(02)01546-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045949858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3223(02)01546-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045949858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/lm.77404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046368326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-clinpsy-050212-185542", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048762258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0005-7894(02)80035-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049281517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000050323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049449207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0146-6402(93)90012-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049654786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cpr.2005.07.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050155306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cpr.2015.07.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050222310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brat.2004.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050702019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.beth.2009.07.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052563332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/08917779208248798", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053005221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0005-7967(97)10016-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053032771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1026//0012-1924.48.3.141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056333565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1026/0084-5345.31.2.110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056337126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1026/0084-5345.32.1.24", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056337177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.v69n0415", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072210176"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "Exposure therapy is highly effective in treating excessive fear related to specific objects and/or situations. However, patients with anxiety disorders often display a generalization of fear responses toward conceptually and perceptually related stimuli and situations. It is unclear whether the beneficial effects of exposure on fear reduction toward treated fear stimuli can extend to untreated fear stimuli. Here, we investigated whether basic principles of extinction generalization apply to exposure. Spider-phobic participants were randomly assigned to either two sessions of exposure treatment (n=23) with spiders or no-treatment (n=24). Prior to and after treatment, behavioral approach tests (BATs) were conducted to examine avoidance, fear and disgust responses toward the treated phobic stimulus (spider as the extinction stimulus). Likewise, BATs with the untreated fear stimulus (cockroach) were conducted to dissect the generalization of treatment effects. Treatment was highly effective in increasing approach behavior toward both treated and untreated fear stimuli. Generalization of treatment effects were evident on the behavioral (approach distance during the BAT), subjective (fear levels during the BAT) and psychophysiological level (heart rate during the BAT). However, a stronger decline in disgust was only evident for the treated fear stimulus. Notably, the herein attained generalization effects were not context-dependent. Hence, exposure therapy for spider phobia was effective in reducing fear of untreated stimuli which share common fear-evoking characteristics with spiders but were never presented during the respective exposure treatment. These findings provide clinical evidence for extinction generalization across different fear-evoking stimuli mediated via exposure.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/npp.2017.119", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1099176", 
        "issn": [
          "0893-133X", 
          "1740-634X"
        ], 
        "name": "Neuropsychopharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "13", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "42"
      }
    ], 
    "name": "Generalization of Extinguished Fear to Untreated Fear Stimuli after Exposure", 
    "pagination": "2545", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fca6d31775ae598f1f8bf4a5ca465571a7bc26377f6ba31a1c5bce85754229b9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28589965"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8904907"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/npp.2017.119"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1085913966"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/npp.2017.119", 
      "https://app.dimensions.ai/details/publication/pub.1085913966"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:47", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000445.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/npp2017119"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/npp.2017.119'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/npp.2017.119'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/npp.2017.119'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/npp.2017.119'


 

This table displays all metadata directly associated to this object as RDF triples.

271 TRIPLES      21 PREDICATES      86 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/npp.2017.119 schema:about N08ba7c55ae4c40f08fcc24400bbf7a5b
2 N23806e587feb405984bd7f8819e35116
3 N238633e41c82429f98610b601c00622f
4 N30e9500abc074384a97fbe1f0d73a166
5 N3e325826eb8641a5ac1650ada6e5af89
6 N5d03e13cd5af4c3582d93e8f8971c22a
7 N69f9923b00fb4f0faabd9650080db78d
8 N729d0bc29faa4327b0826a49bdfa2b01
9 N85fed8a9818d4a46b0fb1babe90007a4
10 N938dfe01bd6b4b988380fd5fddfbd1e8
11 Na46b1e75baa34b78bf6f12402e6ebd4b
12 Nb18bfbc4ea454502a2ac527056c3c536
13 Nbdb6fdd1c3b44a29811f9b6921a7ffcb
14 Nc4628d15e10e429ebf5b3272ccac0c17
15 Ne123f46089e24ee0aa67767400c31e40
16 Nf6878b8bb4434665a065bad0b54b4531
17 Nf9a66806f53d4e96a5bf1c708aa53380
18 anzsrc-for:17
19 anzsrc-for:1701
20 schema:author Ndeb676971a944061b3b879383b874bb4
21 schema:citation https://doi.org/10.1002/da.22356
22 https://doi.org/10.1016/0146-6402(93)90012-q
23 https://doi.org/10.1016/j.beth.2009.07.002
24 https://doi.org/10.1016/j.beth.2014.10.001
25 https://doi.org/10.1016/j.biopsych.2015.04.010
26 https://doi.org/10.1016/j.brat.2004.02.005
27 https://doi.org/10.1016/j.brat.2007.10.003
28 https://doi.org/10.1016/j.brat.2014.04.006
29 https://doi.org/10.1016/j.cpr.2005.07.003
30 https://doi.org/10.1016/j.cpr.2015.07.001
31 https://doi.org/10.1016/j.janxdis.2006.05.001
32 https://doi.org/10.1016/j.jpsychires.2012.04.015
33 https://doi.org/10.1016/j.tics.2014.12.003
34 https://doi.org/10.1016/s0005-7894(02)80035-1
35 https://doi.org/10.1016/s0005-7967(01)00094-8
36 https://doi.org/10.1016/s0005-7967(09)80011-9
37 https://doi.org/10.1016/s0005-7967(97)10016-x
38 https://doi.org/10.1016/s0005-7967(97)10017-1
39 https://doi.org/10.1016/s0005-7967(98)00106-5
40 https://doi.org/10.1016/s0006-3223(02)01546-9
41 https://doi.org/10.1016/s0887-6185(01)00089-5
42 https://doi.org/10.1016/s0887-6185(02)00173-1
43 https://doi.org/10.1026/0012-1924.48.3.141
44 https://doi.org/10.1026/0084-5345.31.2.110
45 https://doi.org/10.1026/0084-5345.32.1.24
46 https://doi.org/10.1037/0022-006x.67.4.599
47 https://doi.org/10.1037/a0018916
48 https://doi.org/10.1080/02699930441000300
49 https://doi.org/10.1080/08917779208248798
50 https://doi.org/10.1093/clipsy.7.3.291
51 https://doi.org/10.1097/01.nmd.0000253843.70149.9a
52 https://doi.org/10.1101/lm.77404
53 https://doi.org/10.1146/annurev-clinpsy-050212-185542
54 https://doi.org/10.1159/000050321
55 https://doi.org/10.1159/000050322
56 https://doi.org/10.1159/000050323
57 https://doi.org/10.1177/0956797614535401
58 https://doi.org/10.1192/bjp.bp.106.032631
59 https://doi.org/10.1371/journal.pone.0096569
60 https://doi.org/10.4088/jcp.v69n0415
61 schema:datePublished 2017-12
62 schema:datePublishedReg 2017-12-01
63 schema:description Exposure therapy is highly effective in treating excessive fear related to specific objects and/or situations. However, patients with anxiety disorders often display a generalization of fear responses toward conceptually and perceptually related stimuli and situations. It is unclear whether the beneficial effects of exposure on fear reduction toward treated fear stimuli can extend to untreated fear stimuli. Here, we investigated whether basic principles of extinction generalization apply to exposure. Spider-phobic participants were randomly assigned to either two sessions of exposure treatment (n=23) with spiders or no-treatment (n=24). Prior to and after treatment, behavioral approach tests (BATs) were conducted to examine avoidance, fear and disgust responses toward the treated phobic stimulus (spider as the extinction stimulus). Likewise, BATs with the untreated fear stimulus (cockroach) were conducted to dissect the generalization of treatment effects. Treatment was highly effective in increasing approach behavior toward both treated and untreated fear stimuli. Generalization of treatment effects were evident on the behavioral (approach distance during the BAT), subjective (fear levels during the BAT) and psychophysiological level (heart rate during the BAT). However, a stronger decline in disgust was only evident for the treated fear stimulus. Notably, the herein attained generalization effects were not context-dependent. Hence, exposure therapy for spider phobia was effective in reducing fear of untreated stimuli which share common fear-evoking characteristics with spiders but were never presented during the respective exposure treatment. These findings provide clinical evidence for extinction generalization across different fear-evoking stimuli mediated via exposure.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree true
67 schema:isPartOf N1f540a62d3d4412fa014eb556a6d8c36
68 N47e54c699b344ec0b6af80fb3c9698f7
69 sg:journal.1099176
70 schema:name Generalization of Extinguished Fear to Untreated Fear Stimuli after Exposure
71 schema:pagination 2545
72 schema:productId N05bba36387b74984ad149f9afbae2b4b
73 N47a128f7d1e64316972ad5389c7fccb2
74 N64768d20494f4a1699d4551dfe578c23
75 N6541684f471b40d9be20a32320ee0eb5
76 N82e3561eb6f1405ea4bbb4d6f29ce33c
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085913966
78 https://doi.org/10.1038/npp.2017.119
79 schema:sdDatePublished 2019-04-10T19:47
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N0674df5bad924d97aeb675dd03803a0b
82 schema:url https://www.nature.com/articles/npp2017119
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N05bba36387b74984ad149f9afbae2b4b schema:name doi
87 schema:value 10.1038/npp.2017.119
88 rdf:type schema:PropertyValue
89 N0674df5bad924d97aeb675dd03803a0b schema:name Springer Nature - SN SciGraph project
90 rdf:type schema:Organization
91 N08ba7c55ae4c40f08fcc24400bbf7a5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Fear
93 rdf:type schema:DefinedTerm
94 N1f540a62d3d4412fa014eb556a6d8c36 schema:volumeNumber 42
95 rdf:type schema:PublicationVolume
96 N23806e587feb405984bd7f8819e35116 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Analysis of Variance
98 rdf:type schema:DefinedTerm
99 N238633e41c82429f98610b601c00622f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Treatment Outcome
101 rdf:type schema:DefinedTerm
102 N30e9500abc074384a97fbe1f0d73a166 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Cockroaches
104 rdf:type schema:DefinedTerm
105 N3e325826eb8641a5ac1650ada6e5af89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Choice Behavior
107 rdf:type schema:DefinedTerm
108 N47a128f7d1e64316972ad5389c7fccb2 schema:name dimensions_id
109 schema:value pub.1085913966
110 rdf:type schema:PropertyValue
111 N47e54c699b344ec0b6af80fb3c9698f7 schema:issueNumber 13
112 rdf:type schema:PublicationIssue
113 N5d03e13cd5af4c3582d93e8f8971c22a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Extinction, Psychological
115 rdf:type schema:DefinedTerm
116 N62ccb289817c47219a548dd5b44a4432 rdf:first sg:person.0756263333.73
117 rdf:rest rdf:nil
118 N64768d20494f4a1699d4551dfe578c23 schema:name pubmed_id
119 schema:value 28589965
120 rdf:type schema:PropertyValue
121 N6541684f471b40d9be20a32320ee0eb5 schema:name readcube_id
122 schema:value fca6d31775ae598f1f8bf4a5ca465571a7bc26377f6ba31a1c5bce85754229b9
123 rdf:type schema:PropertyValue
124 N69f9923b00fb4f0faabd9650080db78d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Phobic Disorders
126 rdf:type schema:DefinedTerm
127 N729d0bc29faa4327b0826a49bdfa2b01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Neuropsychological Tests
129 rdf:type schema:DefinedTerm
130 N82e3561eb6f1405ea4bbb4d6f29ce33c schema:name nlm_unique_id
131 schema:value 8904907
132 rdf:type schema:PropertyValue
133 N85fed8a9818d4a46b0fb1babe90007a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Implosive Therapy
135 rdf:type schema:DefinedTerm
136 N91c8c1f91b5e41f1876700c40e912da7 rdf:first sg:person.015050023035.66
137 rdf:rest N62ccb289817c47219a548dd5b44a4432
138 N938dfe01bd6b4b988380fd5fddfbd1e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Heart Rate
140 rdf:type schema:DefinedTerm
141 Na46b1e75baa34b78bf6f12402e6ebd4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Male
143 rdf:type schema:DefinedTerm
144 Nb18bfbc4ea454502a2ac527056c3c536 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Generalization (Psychology)
146 rdf:type schema:DefinedTerm
147 Nbdb6fdd1c3b44a29811f9b6921a7ffcb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Female
149 rdf:type schema:DefinedTerm
150 Nc4628d15e10e429ebf5b3272ccac0c17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Spiders
152 rdf:type schema:DefinedTerm
153 Ndeb676971a944061b3b879383b874bb4 rdf:first sg:person.0737126063.26
154 rdf:rest N91c8c1f91b5e41f1876700c40e912da7
155 Ne123f46089e24ee0aa67767400c31e40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Animals
157 rdf:type schema:DefinedTerm
158 Nf6878b8bb4434665a065bad0b54b4531 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Humans
160 rdf:type schema:DefinedTerm
161 Nf9a66806f53d4e96a5bf1c708aa53380 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Young Adult
163 rdf:type schema:DefinedTerm
164 anzsrc-for:17 schema:inDefinedTermSet anzsrc-for:
165 schema:name Psychology and Cognitive Sciences
166 rdf:type schema:DefinedTerm
167 anzsrc-for:1701 schema:inDefinedTermSet anzsrc-for:
168 schema:name Psychology
169 rdf:type schema:DefinedTerm
170 sg:journal.1099176 schema:issn 0893-133X
171 1740-634X
172 schema:name Neuropsychopharmacology
173 rdf:type schema:Periodical
174 sg:person.015050023035.66 schema:affiliation https://www.grid.ac/institutes/grid.5570.7
175 schema:familyName Margraf
176 schema:givenName Jürgen
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015050023035.66
178 rdf:type schema:Person
179 sg:person.0737126063.26 schema:affiliation https://www.grid.ac/institutes/grid.5570.7
180 schema:familyName Preusser
181 schema:givenName Friederike
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737126063.26
183 rdf:type schema:Person
184 sg:person.0756263333.73 schema:affiliation https://www.grid.ac/institutes/grid.5570.7
185 schema:familyName Zlomuzica
186 schema:givenName Armin
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756263333.73
188 rdf:type schema:Person
189 https://doi.org/10.1002/da.22356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037825027
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/0146-6402(93)90012-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1049654786
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/j.beth.2009.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052563332
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/j.beth.2014.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005724095
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/j.biopsych.2015.04.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020900036
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/j.brat.2004.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050702019
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/j.brat.2007.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017064399
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.brat.2014.04.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031124168
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.cpr.2005.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050155306
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.cpr.2015.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050222310
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.janxdis.2006.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026668177
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.jpsychires.2012.04.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009938999
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.tics.2014.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005769758
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/s0005-7894(02)80035-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049281517
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/s0005-7967(01)00094-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045748817
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/s0005-7967(09)80011-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045937036
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/s0005-7967(97)10016-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053032771
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/s0005-7967(97)10017-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014554267
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/s0005-7967(98)00106-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012531786
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/s0006-3223(02)01546-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045949858
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0887-6185(01)00089-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035512174
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/s0887-6185(02)00173-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041347515
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1026/0012-1924.48.3.141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056333565
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1026/0084-5345.31.2.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056337126
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1026/0084-5345.32.1.24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056337177
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1037/0022-006x.67.4.599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036259444
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1037/a0018916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039284942
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1080/02699930441000300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002373546
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1080/08917779208248798 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053005221
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1093/clipsy.7.3.291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037833506
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1097/01.nmd.0000253843.70149.9a schema:sameAs https://app.dimensions.ai/details/publication/pub.1044396558
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1101/lm.77404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046368326
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1146/annurev-clinpsy-050212-185542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048762258
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1159/000050321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035991814
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1159/000050322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031052605
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1159/000050323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049449207
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1177/0956797614535401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014115188
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1192/bjp.bp.106.032631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032585061
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1371/journal.pone.0096569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001661783
266 rdf:type schema:CreativeWork
267 https://doi.org/10.4088/jcp.v69n0415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072210176
268 rdf:type schema:CreativeWork
269 https://www.grid.ac/institutes/grid.5570.7 schema:alternateName Ruhr University Bochum
270 schema:name Mental Health Research and Treatment Center, Ruhr-University Bochum, Bochum, Germany
271 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...