White Matter Microstructural Alterations in Children with ADHD: Categorical and Dimensional Perspectives View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-01

AUTHORS

Zhao-Min Wu, Janita Bralten, Qing-Jiu Cao, Martine Hoogman, Marcel P Zwiers, Li An, Li Sun, Li Yang, Yu-Feng Zang, Barbara Franke, Yu-Feng Wang

ABSTRACT

Studies of brain alterations in children with attention-deficit/hyperactivity disorder (ADHD) have shown heterogeneous results. The aims of the current study were to investigate white matter microstructure in children using both categorical and dimensional definitions of ADHD and to determine the functional consequences of observed alterations. In a large single-site sample of children (aged 8-15 years) with ADHD (n=83) and healthy controls (n=122), we used tract-based spatial statistics on diffusion tensor imaging data to investigate whole-skeleton differences of fractional anisotropy (FA), mean, axial, and radial diffusivity (MD, AD, RD), and mode of anisotropy related to ADHD status (categorical) and symptom severity (dimensional). For categorical differences observed, we analyzed their association with cognitive functioning in working memory and inhibition. Compared with healthy controls, children with ADHD showed decreased FA and increased RD in widespread, overlapping brain regions, mainly in corpus callosum (CC) and major tracts in the left hemisphere. Decreased FA was associated with inhibition performance in the participants with ADHD. Using dimensional definitions, greater hyperactivity/impulsivity symptom severity was associated with higher FA also in widespread regions, mainly in CC and major tracts in the right hemisphere. Our study showed white matter alterations to be related to ADHD status and symptom severity in patients. The coexistence of decreased FA and increased RD in the absence of alterations in MD or AD might indicate altered myelination as a pathophysiological factor in ADHD. More... »

PAGES

572

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/npp.2016.223

DOI

http://dx.doi.org/10.1038/npp.2016.223

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007372466

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27681441


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1701", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Psychology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/17", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Psychology and Cognitive Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Attention Deficit Disorder with Hyperactivity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diffusion Tensor Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inhibition (Psychology)", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Memory, Short-Term", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "White Matter", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen", 
          "id": "https://www.grid.ac/institutes/grid.5590.9", 
          "name": [
            "Institute of Mental Health, National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing, China", 
            "Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China", 
            "Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands", 
            "Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Zhao-Min", 
        "id": "sg:person.01065074154.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065074154.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen", 
          "id": "https://www.grid.ac/institutes/grid.5590.9", 
          "name": [
            "Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands", 
            "Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bralten", 
        "givenName": "Janita", 
        "id": "sg:person.01076356174.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076356174.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University Sixth Hospital", 
          "id": "https://www.grid.ac/institutes/grid.459847.3", 
          "name": [
            "Institute of Mental Health, National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing, China", 
            "Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cao", 
        "givenName": "Qing-Jiu", 
        "id": "sg:person.0652406057.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652406057.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen", 
          "id": "https://www.grid.ac/institutes/grid.5590.9", 
          "name": [
            "Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands", 
            "Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoogman", 
        "givenName": "Martine", 
        "id": "sg:person.0660631451.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660631451.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen", 
          "id": "https://www.grid.ac/institutes/grid.5590.9", 
          "name": [
            "Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zwiers", 
        "givenName": "Marcel P", 
        "id": "sg:person.01221610164.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221610164.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University Sixth Hospital", 
          "id": "https://www.grid.ac/institutes/grid.459847.3", 
          "name": [
            "Institute of Mental Health, National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing, China", 
            "Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "An", 
        "givenName": "Li", 
        "id": "sg:person.01276734747.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276734747.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University Sixth Hospital", 
          "id": "https://www.grid.ac/institutes/grid.459847.3", 
          "name": [
            "Institute of Mental Health, National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing, China", 
            "Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Li", 
        "id": "sg:person.01215227376.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215227376.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University Sixth Hospital", 
          "id": "https://www.grid.ac/institutes/grid.459847.3", 
          "name": [
            "Institute of Mental Health, National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing, China", 
            "Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Li", 
        "id": "sg:person.0660203677.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660203677.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hangzhou Normal University", 
          "id": "https://www.grid.ac/institutes/grid.410595.c", 
          "name": [
            "Center for Cognition and Brain Disorders, Hangzhou Normal University; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zang", 
        "givenName": "Yu-Feng", 
        "id": "sg:person.014547771132.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014547771132.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Radboud University Nijmegen", 
          "id": "https://www.grid.ac/institutes/grid.5590.9", 
          "name": [
            "Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands", 
            "Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands", 
            "Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Franke", 
        "givenName": "Barbara", 
        "id": "sg:person.0734362031.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734362031.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Peking University Sixth Hospital", 
          "id": "https://www.grid.ac/institutes/grid.459847.3", 
          "name": [
            "Institute of Mental Health, National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing, China", 
            "Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Yu-Feng", 
        "id": "sg:person.01346046201.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346046201.54"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.biopsych.2008.10.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000803900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hbm.22169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002795560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2015.10.068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005157371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004583-199707000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005549424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004583-199707000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005549424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2014.06.058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005587266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1076/chin.6.3.235.3152", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005857787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2011.08.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009913507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(15)00238-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011656620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pnpbp.2015.04.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011825513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaac.2014.05.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012026639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11682-015-9470-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012368113", 
          "https://doi.org/10.1007/s11682-015-9470-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaac.2015.11.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015297645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pscychresns.2016.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019491325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pscychresns.2016.04.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019491325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1542/peds.2014-3482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020705323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0028-3932(71)90067-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022259601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2006.02.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023372670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/chi.0b013e3181ba3dbb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023573212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/chi.0b013e3181ba3dbb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023573212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/chi.0b013e3181ba3dbb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023573212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hbm.22492", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023918193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajmg.b.32169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029232288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.2010.07110.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029507265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.2010.07110.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029507265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2008.03.061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035103899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/brain.2011.0071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037237073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2007.12.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037350849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/dbp.0b013e3181dcaa8b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037972415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/dbp.0b013e3181dcaa8b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037972415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/dbp.0b013e3181dcaa8b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037972415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neubiorev.2012.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040569469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pscychresns.2012.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041138736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nicl.2015.01.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041930432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neubiorev.2016.07.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042646279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neubiorev.2016.07.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042646279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaac.2015.08.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044099133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pnpbp.2014.10.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044679697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2013.12.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044684782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2010.06.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045581436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajmg.b.30672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047304513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1192/bjp.bp.107.048827", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048266831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jnp.12049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049709616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaac.2014.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051608661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12993-015-0060-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051619506", 
          "https://doi.org/10.1186/s12993-015-0060-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12993-015-0060-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051619506", 
          "https://doi.org/10.1186/s12993-015-0060-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/00222194030360011001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053785984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/00222194030360011001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053785984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0033291712001869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054083198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/appi.ajp.2007.06101754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063497746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/appi.ajp.2010.10070948", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063499108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0284185114545147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078965473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0284185114545147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078965473"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-01", 
    "datePublishedReg": "2017-01-01", 
    "description": "Studies of brain alterations in children with attention-deficit/hyperactivity disorder (ADHD) have shown heterogeneous results. The aims of the current study were to investigate white matter microstructure in children using both categorical and dimensional definitions of ADHD and to determine the functional consequences of observed alterations. In a large single-site sample of children (aged 8-15 years) with ADHD (n=83) and healthy controls (n=122), we used tract-based spatial statistics on diffusion tensor imaging data to investigate whole-skeleton differences of fractional anisotropy (FA), mean, axial, and radial diffusivity (MD, AD, RD), and mode of anisotropy related to ADHD status (categorical) and symptom severity (dimensional). For categorical differences observed, we analyzed their association with cognitive functioning in working memory and inhibition. Compared with healthy controls, children with ADHD showed decreased FA and increased RD in widespread, overlapping brain regions, mainly in corpus callosum (CC) and major tracts in the left hemisphere. Decreased FA was associated with inhibition performance in the participants with ADHD. Using dimensional definitions, greater hyperactivity/impulsivity symptom severity was associated with higher FA also in widespread regions, mainly in CC and major tracts in the right hemisphere. Our study showed white matter alterations to be related to ADHD status and symptom severity in patients. The coexistence of decreased FA and increased RD in the absence of alterations in MD or AD might indicate altered myelination as a pathophysiological factor in ADHD.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/npp.2016.223", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1099176", 
        "issn": [
          "0893-133X", 
          "1740-634X"
        ], 
        "name": "Neuropsychopharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "42"
      }
    ], 
    "name": "White Matter Microstructural Alterations in Children with ADHD: Categorical and Dimensional Perspectives", 
    "pagination": "572", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "231df89b7b6924f8a0059b55290326422b38f9973fdf4d466b6b9fb6b22f3a69"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27681441"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8904907"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/npp.2016.223"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1007372466"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/npp.2016.223", 
      "https://app.dimensions.ai/details/publication/pub.1007372466"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000436.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/npp2016223"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/npp.2016.223'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/npp.2016.223'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/npp.2016.223'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/npp.2016.223'


 

This table displays all metadata directly associated to this object as RDF triples.

326 TRIPLES      21 PREDICATES      83 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/npp.2016.223 schema:about N00301f822a9a4e338625f64d9578d5f5
2 N008e8e3384444c81899445c1f7de2a12
3 N2101f7e7c6c848e6b38ee947a49bb279
4 N4c2b92fa983b442da3962eccb3254ff1
5 N621e5ac187a34ef5a87ec5f1fa2dd793
6 N790f9fcf97fb41a48832f1c8ea35eec5
7 Na51bf874b4fa4aa5becb31a558fdc95d
8 Ncc3c497502e8417c9d3d148c10d23084
9 Nd3edf2b6c29940baa7a5e7b39beb3b82
10 Nd6a645ae7cf542999096afbdd13013e4
11 Nf560ebd48b4c4eb289553fc2779c6ba7
12 Nfcfbb927fc2e4377b98e9694a571114b
13 anzsrc-for:17
14 anzsrc-for:1701
15 schema:author N05e1dc4d768541e79e8642384204e144
16 schema:citation sg:pub.10.1007/s11682-015-9470-9
17 sg:pub.10.1186/s12993-015-0060-1
18 https://doi.org/10.1002/ajmg.b.30672
19 https://doi.org/10.1002/ajmg.b.32169
20 https://doi.org/10.1002/hbm.22169
21 https://doi.org/10.1002/hbm.22492
22 https://doi.org/10.1016/0028-3932(71)90067-4
23 https://doi.org/10.1016/j.biopsych.2008.10.015
24 https://doi.org/10.1016/j.biopsych.2011.08.013
25 https://doi.org/10.1016/j.biopsych.2013.12.013
26 https://doi.org/10.1016/j.jaac.2014.05.001
27 https://doi.org/10.1016/j.jaac.2014.05.011
28 https://doi.org/10.1016/j.jaac.2015.08.014
29 https://doi.org/10.1016/j.jaac.2015.11.011
30 https://doi.org/10.1016/j.neubiorev.2012.01.003
31 https://doi.org/10.1016/j.neubiorev.2016.07.022
32 https://doi.org/10.1016/j.neuroimage.2006.02.024
33 https://doi.org/10.1016/j.neuroimage.2007.12.035
34 https://doi.org/10.1016/j.neuroimage.2008.03.061
35 https://doi.org/10.1016/j.neuroimage.2010.06.014
36 https://doi.org/10.1016/j.neuroimage.2015.10.068
37 https://doi.org/10.1016/j.neuroscience.2014.06.058
38 https://doi.org/10.1016/j.nicl.2015.01.004
39 https://doi.org/10.1016/j.pnpbp.2014.10.014
40 https://doi.org/10.1016/j.pnpbp.2015.04.008
41 https://doi.org/10.1016/j.pscychresns.2012.04.001
42 https://doi.org/10.1016/j.pscychresns.2016.04.002
43 https://doi.org/10.1016/s0140-6736(15)00238-x
44 https://doi.org/10.1017/s0033291712001869
45 https://doi.org/10.1076/chin.6.3.235.3152
46 https://doi.org/10.1089/brain.2011.0071
47 https://doi.org/10.1097/00004583-199707000-00021
48 https://doi.org/10.1097/chi.0b013e3181ba3dbb
49 https://doi.org/10.1097/dbp.0b013e3181dcaa8b
50 https://doi.org/10.1111/j.1460-9568.2010.07110.x
51 https://doi.org/10.1111/jnp.12049
52 https://doi.org/10.1176/appi.ajp.2007.06101754
53 https://doi.org/10.1176/appi.ajp.2010.10070948
54 https://doi.org/10.1177/00222194030360011001
55 https://doi.org/10.1177/0284185114545147
56 https://doi.org/10.1192/bjp.bp.107.048827
57 https://doi.org/10.1542/peds.2014-3482
58 schema:datePublished 2017-01
59 schema:datePublishedReg 2017-01-01
60 schema:description Studies of brain alterations in children with attention-deficit/hyperactivity disorder (ADHD) have shown heterogeneous results. The aims of the current study were to investigate white matter microstructure in children using both categorical and dimensional definitions of ADHD and to determine the functional consequences of observed alterations. In a large single-site sample of children (aged 8-15 years) with ADHD (n=83) and healthy controls (n=122), we used tract-based spatial statistics on diffusion tensor imaging data to investigate whole-skeleton differences of fractional anisotropy (FA), mean, axial, and radial diffusivity (MD, AD, RD), and mode of anisotropy related to ADHD status (categorical) and symptom severity (dimensional). For categorical differences observed, we analyzed their association with cognitive functioning in working memory and inhibition. Compared with healthy controls, children with ADHD showed decreased FA and increased RD in widespread, overlapping brain regions, mainly in corpus callosum (CC) and major tracts in the left hemisphere. Decreased FA was associated with inhibition performance in the participants with ADHD. Using dimensional definitions, greater hyperactivity/impulsivity symptom severity was associated with higher FA also in widespread regions, mainly in CC and major tracts in the right hemisphere. Our study showed white matter alterations to be related to ADHD status and symptom severity in patients. The coexistence of decreased FA and increased RD in the absence of alterations in MD or AD might indicate altered myelination as a pathophysiological factor in ADHD.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree true
64 schema:isPartOf N0335e16b0cdb4274bea51acd5fe9a2cb
65 N5b0acbc6b04447b191f2df93d22e57d4
66 sg:journal.1099176
67 schema:name White Matter Microstructural Alterations in Children with ADHD: Categorical and Dimensional Perspectives
68 schema:pagination 572
69 schema:productId N147888dd75b14fa78cdc19b5cbd9694a
70 N4ad9984a7a104f86bb9cdcabd262a23a
71 N6c3d4f8c60be410aa3bb6cf1356e803b
72 Naaf8cee412dc4b5e8b1b9941a140a2be
73 Nb056dbc0cc094c70ab748961c9a49582
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007372466
75 https://doi.org/10.1038/npp.2016.223
76 schema:sdDatePublished 2019-04-10T17:20
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher Nac2eef7a83b143df9e33bcbd06bf554d
79 schema:url https://www.nature.com/articles/npp2016223
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N00301f822a9a4e338625f64d9578d5f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Male
85 rdf:type schema:DefinedTerm
86 N008e8e3384444c81899445c1f7de2a12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Diffusion Tensor Imaging
88 rdf:type schema:DefinedTerm
89 N0335e16b0cdb4274bea51acd5fe9a2cb schema:issueNumber 2
90 rdf:type schema:PublicationIssue
91 N05e1dc4d768541e79e8642384204e144 rdf:first sg:person.01065074154.83
92 rdf:rest N77c96e3f9e3140998f7fd2c9cd8831d5
93 N06769fbd221949f59624a957529c5074 rdf:first sg:person.0652406057.31
94 rdf:rest Nd1ae33a979794b90aae875bfa88c6276
95 N0ffefe995888449f8fc8948f8abb29bd rdf:first sg:person.01276734747.59
96 rdf:rest Na63d4f1a0b18436f8dde7ec7d88386cc
97 N147888dd75b14fa78cdc19b5cbd9694a schema:name nlm_unique_id
98 schema:value 8904907
99 rdf:type schema:PropertyValue
100 N2101f7e7c6c848e6b38ee947a49bb279 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Memory, Short-Term
102 rdf:type schema:DefinedTerm
103 N28e10c50f778462f9b4c786c614c5802 rdf:first sg:person.01346046201.54
104 rdf:rest rdf:nil
105 N2f314a77214e4c809e6f03de7accb042 rdf:first sg:person.014547771132.21
106 rdf:rest Ndb566ad0ebc9428696eb9a032846b4c0
107 N45f332a81e92404bbb821800075ecaf5 rdf:first sg:person.01221610164.40
108 rdf:rest N0ffefe995888449f8fc8948f8abb29bd
109 N4ad9984a7a104f86bb9cdcabd262a23a schema:name dimensions_id
110 schema:value pub.1007372466
111 rdf:type schema:PropertyValue
112 N4c2b92fa983b442da3962eccb3254ff1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Brain
114 rdf:type schema:DefinedTerm
115 N5b0acbc6b04447b191f2df93d22e57d4 schema:volumeNumber 42
116 rdf:type schema:PublicationVolume
117 N621e5ac187a34ef5a87ec5f1fa2dd793 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Female
119 rdf:type schema:DefinedTerm
120 N6c3d4f8c60be410aa3bb6cf1356e803b schema:name pubmed_id
121 schema:value 27681441
122 rdf:type schema:PropertyValue
123 N77c96e3f9e3140998f7fd2c9cd8831d5 rdf:first sg:person.01076356174.67
124 rdf:rest N06769fbd221949f59624a957529c5074
125 N790f9fcf97fb41a48832f1c8ea35eec5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name White Matter
127 rdf:type schema:DefinedTerm
128 Na51bf874b4fa4aa5becb31a558fdc95d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Child
130 rdf:type schema:DefinedTerm
131 Na63d4f1a0b18436f8dde7ec7d88386cc rdf:first sg:person.01215227376.75
132 rdf:rest Nebe13300243648c687664a04462f37fb
133 Naaf8cee412dc4b5e8b1b9941a140a2be schema:name readcube_id
134 schema:value 231df89b7b6924f8a0059b55290326422b38f9973fdf4d466b6b9fb6b22f3a69
135 rdf:type schema:PropertyValue
136 Nac2eef7a83b143df9e33bcbd06bf554d schema:name Springer Nature - SN SciGraph project
137 rdf:type schema:Organization
138 Nb056dbc0cc094c70ab748961c9a49582 schema:name doi
139 schema:value 10.1038/npp.2016.223
140 rdf:type schema:PropertyValue
141 Ncc3c497502e8417c9d3d148c10d23084 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Humans
143 rdf:type schema:DefinedTerm
144 Nd1ae33a979794b90aae875bfa88c6276 rdf:first sg:person.0660631451.54
145 rdf:rest N45f332a81e92404bbb821800075ecaf5
146 Nd3edf2b6c29940baa7a5e7b39beb3b82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Adolescent
148 rdf:type schema:DefinedTerm
149 Nd6a645ae7cf542999096afbdd13013e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Attention Deficit Disorder with Hyperactivity
151 rdf:type schema:DefinedTerm
152 Ndb566ad0ebc9428696eb9a032846b4c0 rdf:first sg:person.0734362031.26
153 rdf:rest N28e10c50f778462f9b4c786c614c5802
154 Nebe13300243648c687664a04462f37fb rdf:first sg:person.0660203677.05
155 rdf:rest N2f314a77214e4c809e6f03de7accb042
156 Nf560ebd48b4c4eb289553fc2779c6ba7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Severity of Illness Index
158 rdf:type schema:DefinedTerm
159 Nfcfbb927fc2e4377b98e9694a571114b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Inhibition (Psychology)
161 rdf:type schema:DefinedTerm
162 anzsrc-for:17 schema:inDefinedTermSet anzsrc-for:
163 schema:name Psychology and Cognitive Sciences
164 rdf:type schema:DefinedTerm
165 anzsrc-for:1701 schema:inDefinedTermSet anzsrc-for:
166 schema:name Psychology
167 rdf:type schema:DefinedTerm
168 sg:journal.1099176 schema:issn 0893-133X
169 1740-634X
170 schema:name Neuropsychopharmacology
171 rdf:type schema:Periodical
172 sg:person.01065074154.83 schema:affiliation https://www.grid.ac/institutes/grid.5590.9
173 schema:familyName Wu
174 schema:givenName Zhao-Min
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065074154.83
176 rdf:type schema:Person
177 sg:person.01076356174.67 schema:affiliation https://www.grid.ac/institutes/grid.5590.9
178 schema:familyName Bralten
179 schema:givenName Janita
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076356174.67
181 rdf:type schema:Person
182 sg:person.01215227376.75 schema:affiliation https://www.grid.ac/institutes/grid.459847.3
183 schema:familyName Sun
184 schema:givenName Li
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215227376.75
186 rdf:type schema:Person
187 sg:person.01221610164.40 schema:affiliation https://www.grid.ac/institutes/grid.5590.9
188 schema:familyName Zwiers
189 schema:givenName Marcel P
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221610164.40
191 rdf:type schema:Person
192 sg:person.01276734747.59 schema:affiliation https://www.grid.ac/institutes/grid.459847.3
193 schema:familyName An
194 schema:givenName Li
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276734747.59
196 rdf:type schema:Person
197 sg:person.01346046201.54 schema:affiliation https://www.grid.ac/institutes/grid.459847.3
198 schema:familyName Wang
199 schema:givenName Yu-Feng
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346046201.54
201 rdf:type schema:Person
202 sg:person.014547771132.21 schema:affiliation https://www.grid.ac/institutes/grid.410595.c
203 schema:familyName Zang
204 schema:givenName Yu-Feng
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014547771132.21
206 rdf:type schema:Person
207 sg:person.0652406057.31 schema:affiliation https://www.grid.ac/institutes/grid.459847.3
208 schema:familyName Cao
209 schema:givenName Qing-Jiu
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652406057.31
211 rdf:type schema:Person
212 sg:person.0660203677.05 schema:affiliation https://www.grid.ac/institutes/grid.459847.3
213 schema:familyName Yang
214 schema:givenName Li
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660203677.05
216 rdf:type schema:Person
217 sg:person.0660631451.54 schema:affiliation https://www.grid.ac/institutes/grid.5590.9
218 schema:familyName Hoogman
219 schema:givenName Martine
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660631451.54
221 rdf:type schema:Person
222 sg:person.0734362031.26 schema:affiliation https://www.grid.ac/institutes/grid.5590.9
223 schema:familyName Franke
224 schema:givenName Barbara
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734362031.26
226 rdf:type schema:Person
227 sg:pub.10.1007/s11682-015-9470-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012368113
228 https://doi.org/10.1007/s11682-015-9470-9
229 rdf:type schema:CreativeWork
230 sg:pub.10.1186/s12993-015-0060-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051619506
231 https://doi.org/10.1186/s12993-015-0060-1
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1002/ajmg.b.30672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047304513
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1002/ajmg.b.32169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029232288
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1002/hbm.22169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002795560
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1002/hbm.22492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023918193
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/0028-3932(71)90067-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022259601
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/j.biopsych.2008.10.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000803900
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/j.biopsych.2011.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009913507
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/j.biopsych.2013.12.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044684782
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/j.jaac.2014.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051608661
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/j.jaac.2014.05.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012026639
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/j.jaac.2015.08.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044099133
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/j.jaac.2015.11.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015297645
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.neubiorev.2012.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040569469
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.neubiorev.2016.07.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042646279
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.neuroimage.2006.02.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023372670
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.neuroimage.2007.12.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037350849
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.neuroimage.2008.03.061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035103899
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.neuroimage.2010.06.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045581436
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.neuroimage.2015.10.068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005157371
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.neuroscience.2014.06.058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005587266
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.nicl.2015.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041930432
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.pnpbp.2014.10.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044679697
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.pnpbp.2015.04.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011825513
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.pscychresns.2012.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041138736
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.pscychresns.2016.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019491325
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/s0140-6736(15)00238-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011656620
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1017/s0033291712001869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054083198
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1076/chin.6.3.235.3152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005857787
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1089/brain.2011.0071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037237073
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1097/00004583-199707000-00021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005549424
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1097/chi.0b013e3181ba3dbb schema:sameAs https://app.dimensions.ai/details/publication/pub.1023573212
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1097/dbp.0b013e3181dcaa8b schema:sameAs https://app.dimensions.ai/details/publication/pub.1037972415
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1111/j.1460-9568.2010.07110.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029507265
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1111/jnp.12049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049709616
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1176/appi.ajp.2007.06101754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063497746
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1176/appi.ajp.2010.10070948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063499108
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1177/00222194030360011001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053785984
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1177/0284185114545147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078965473
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1192/bjp.bp.107.048827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048266831
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1542/peds.2014-3482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020705323
312 rdf:type schema:CreativeWork
313 https://www.grid.ac/institutes/grid.410595.c schema:alternateName Hangzhou Normal University
314 schema:name Center for Cognition and Brain Disorders, Hangzhou Normal University; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, China
315 rdf:type schema:Organization
316 https://www.grid.ac/institutes/grid.459847.3 schema:alternateName Peking University Sixth Hospital
317 schema:name Institute of Mental Health, National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing, China
318 Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China
319 rdf:type schema:Organization
320 https://www.grid.ac/institutes/grid.5590.9 schema:alternateName Radboud University Nijmegen
321 schema:name Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands
322 Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands
323 Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands
324 Institute of Mental Health, National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing, China
325 Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China
326 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...