Convergent Findings for Abnormalities of the NF-κB Signaling Pathway in Schizophrenia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-02

AUTHORS

Panos Roussos, Pavel Katsel, Kenneth L Davis, Stella G Giakoumaki, Todd Lencz, Anil K Malhotra, Larry J Siever, Panos Bitsios, Vahram Haroutunian

ABSTRACT

Neurons exhibit a constitutive level of nuclear factor-κB (NF-κB) signaling and this pathway plays a significant role in neurite outgrowth, activity-dependent plasticity, and cognitive function. Transcription factor analysis was performed in a microarray data set profiled in four different brain regions (n=54 comparison group; n=53 schizophrenia (SZ)). An independent postmortem cohort was used for gene expression (n=24 comparison group; n=22 SZ), protein abundance (n=8 comparison group; n=8 SZ), and NF-κB nuclear activity (n=10 comparison group; n=10 SZ) quantification. Expression quantitative trait locus analysis was performed using publicly available data. Prepulse inhibition (PPI) of the acoustic startle reflex was tested in healthy individuals (n=690). Comparison of microarray data showed that NF-κB was among the transcription factors associated with the differential expression of genes in cases vs controls. NF-κB gene and protein levels and nuclear activation were significantly decreased in the superior temporal gyrus of patients with SZ. Upstream NF-κB genes related to translocation were significantly dysregulated in SZ. The gene expression levels of an NF-κB-associated importin (KPNA4: one of the proteins responsible for the translocation of NF-κB to the nucleus) was decreased in SZ and an SNP within the KPNA4 locus was associated with susceptibility to SZ, reduced KPNA4 expression levels and attenuated PPI of the startle reflex in healthy control subjects. These findings implicate abnormalities of the NF-κB signaling pathway in SZ and provide evidence for an additional possible mechanism affecting the translocation of NF-κB signaling to the nucleus. More... »

PAGES

533

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/npp.2012.215

DOI

http://dx.doi.org/10.1038/npp.2012.215

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017400545

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23132271


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NF-kappa B", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neural Pathways", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Schizophrenia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Temporal Lobe", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Icahn School of Medicine at Mount Sinai", 
          "id": "https://www.grid.ac/institutes/grid.59734.3c", 
          "name": [
            "Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10468, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roussos", 
        "givenName": "Panos", 
        "id": "sg:person.01230420745.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230420745.20"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Katsel", 
        "givenName": "Pavel", 
        "id": "sg:person.01314014327.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314014327.88"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Davis", 
        "givenName": "Kenneth L", 
        "id": "sg:person.0604610137.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604610137.76"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Giakoumaki", 
        "givenName": "Stella G", 
        "id": "sg:person.01276534145.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276534145.69"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Lencz", 
        "givenName": "Todd", 
        "id": "sg:person.01323132157.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323132157.46"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Malhotra", 
        "givenName": "Anil K", 
        "id": "sg:person.0762766773.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762766773.09"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Siever", 
        "givenName": "Larry J", 
        "id": "sg:person.01140360470.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140360470.23"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Bitsios", 
        "givenName": "Panos", 
        "id": "sg:person.01333517660.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333517660.58"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Haroutunian", 
        "givenName": "Vahram", 
        "id": "sg:person.015272745217.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015272745217.30"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/nar/29.4.e21", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001294215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e04-05-0438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001721374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2010.08.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002208651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2008.10.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002447922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.2005.04126.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002636533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.2005.04126.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002636533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3566-08.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003566829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004743482", 
          "https://doi.org/10.1038/nn995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004743482", 
          "https://doi.org/10.1038/nn995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.4763-10.2011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006794118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/npp.2011.78", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007552066", 
          "https://doi.org/10.1038/npp.2011.78"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m206258200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013047608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m500814200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013565275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pnpbp.2008.05.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013735690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.euroneuro.2006.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014003329"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/npp.2011.49", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014063466", 
          "https://doi.org/10.1038/npp.2011.49"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semcdb.2009.04.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018175107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0011351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019942982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0910658107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020845578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.107.072819", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020858268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1534/genetics.107.072819", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020858268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.0148-08.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022249481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2008.06.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025093048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archgenpsychiatry.2011.110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025191600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2008.01.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027357488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2004.03016.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027498255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/schbul/sbp073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027598488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/schbul/sbp073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027598488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.20702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027948281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jnr.20702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027948281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s1461145710001410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028025116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s0893-133x(01)00364-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028903414", 
          "https://doi.org/10.1016/s0893-133x(01)00364-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.0020190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029170965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031429813", 
          "https://doi.org/10.1038/ng1847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031429813", 
          "https://doi.org/10.1038/ng1847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tins.2011.03.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033079594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2011.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033105090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.0060107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033670612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2010.09.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034294369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mcn.2008.01.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035260695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2009.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041237311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041332849", 
          "https://doi.org/10.1038/nrm2083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.021908.132641", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043156499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1819.2010.02094.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043282915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1819.2010.02094.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043282915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044236818", 
          "https://doi.org/10.1038/nature10524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/yco.0b013e3283436eb7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046331296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/yco.0b013e3283436eb7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046331296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.6173-08.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047542479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mcn.2010.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047672473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archpsyc.59.8.686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049582727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archgenpsychiatry.2012.704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051429391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053172161", 
          "https://doi.org/10.1038/ng.940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053172161", 
          "https://doi.org/10.1038/ng.940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0033291708002912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054037092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3002804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062687173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/appi.ajp.2008.07101562", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063498098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/appi.ajp.2008.07101640", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063498102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074669255", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-02", 
    "datePublishedReg": "2013-02-01", 
    "description": "Neurons exhibit a constitutive level of nuclear factor-\u03baB (NF-\u03baB) signaling and this pathway plays a significant role in neurite outgrowth, activity-dependent plasticity, and cognitive function. Transcription factor analysis was performed in a microarray data set profiled in four different brain regions (n=54 comparison group; n=53 schizophrenia (SZ)). An independent postmortem cohort was used for gene expression (n=24 comparison group; n=22 SZ), protein abundance (n=8 comparison group; n=8 SZ), and NF-\u03baB nuclear activity (n=10 comparison group; n=10 SZ) quantification. Expression quantitative trait locus analysis was performed using publicly available data. Prepulse inhibition (PPI) of the acoustic startle reflex was tested in healthy individuals (n=690). Comparison of microarray data showed that NF-\u03baB was among the transcription factors associated with the differential expression of genes in cases vs controls. NF-\u03baB gene and protein levels and nuclear activation were significantly decreased in the superior temporal gyrus of patients with SZ. Upstream NF-\u03baB genes related to translocation were significantly dysregulated in SZ. The gene expression levels of an NF-\u03baB-associated importin (KPNA4: one of the proteins responsible for the translocation of NF-\u03baB to the nucleus) was decreased in SZ and an SNP within the KPNA4 locus was associated with susceptibility to SZ, reduced KPNA4 expression levels and attenuated PPI of the startle reflex in healthy control subjects. These findings implicate abnormalities of the NF-\u03baB signaling pathway in SZ and provide evidence for an additional possible mechanism affecting the translocation of NF-\u03baB signaling to the nucleus.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/npp.2012.215", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2440944", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2549985", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1099176", 
        "issn": [
          "0893-133X", 
          "1740-634X"
        ], 
        "name": "Neuropsychopharmacology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "38"
      }
    ], 
    "name": "Convergent Findings for Abnormalities of the NF-\u03baB Signaling Pathway in Schizophrenia", 
    "pagination": "533", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "52e7173fb956fc2b263ce79f513288ba9bb980f1293e6312a2a21f124b5aeb77"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23132271"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8904907"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/npp.2012.215"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1017400545"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/npp.2012.215", 
      "https://app.dimensions.ai/details/publication/pub.1017400545"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:13", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000436.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/npp2012215"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/npp.2012.215'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/npp.2012.215'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/npp.2012.215'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/npp.2012.215'


 

This table displays all metadata directly associated to this object as RDF triples.

326 TRIPLES      21 PREDICATES      91 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/npp.2012.215 schema:about N033ba4e57d9949a3807c536ed26fcda3
2 N33ad58b39d524d3bbfcdd00600b9fcce
3 N3b530fb103784449a4ec69a4875ab65e
4 N524cd553b3ee406f99dc3cf6fab6336c
5 N65ebaca6c6ab4ddfa5484440434a567d
6 N69ec5684571b4513b84abb295532c0d6
7 N7d97a5556eba472eb4ec28daca6f1bd9
8 N85665ce273404a6b89935e4c544cdee6
9 Na5372466aeb04b97b52c52cd07278be8
10 Nbf2740e3662340ee9cc21172fc9da7e6
11 Nc0c8b328f7cb466ba3249ca84cde4543
12 Nc8073fa25ec44512b08f394a91c23096
13 anzsrc-for:06
14 anzsrc-for:0604
15 schema:author Nb88385e0468943b09bf688ed52e29bb9
16 schema:citation sg:pub.10.1016/s0893-133x(01)00364-5
17 sg:pub.10.1038/nature10524
18 sg:pub.10.1038/ng.940
19 sg:pub.10.1038/ng1847
20 sg:pub.10.1038/nn995
21 sg:pub.10.1038/npp.2011.49
22 sg:pub.10.1038/npp.2011.78
23 sg:pub.10.1038/nrm2083
24 https://app.dimensions.ai/details/publication/pub.1074669255
25 https://doi.org/10.1001/archgenpsychiatry.2011.110
26 https://doi.org/10.1001/archgenpsychiatry.2012.704
27 https://doi.org/10.1001/archpsyc.59.8.686
28 https://doi.org/10.1002/jnr.20702
29 https://doi.org/10.1016/j.biopsych.2008.01.020
30 https://doi.org/10.1016/j.biopsych.2008.10.018
31 https://doi.org/10.1016/j.biopsych.2009.01.003
32 https://doi.org/10.1016/j.biopsych.2010.09.009
33 https://doi.org/10.1016/j.biopsych.2011.01.002
34 https://doi.org/10.1016/j.ejphar.2008.06.033
35 https://doi.org/10.1016/j.euroneuro.2006.01.001
36 https://doi.org/10.1016/j.mcn.2008.01.010
37 https://doi.org/10.1016/j.mcn.2010.01.005
38 https://doi.org/10.1016/j.neuron.2010.08.013
39 https://doi.org/10.1016/j.pnpbp.2008.05.003
40 https://doi.org/10.1016/j.semcdb.2009.04.014
41 https://doi.org/10.1016/j.tins.2011.03.001
42 https://doi.org/10.1017/s0033291708002912
43 https://doi.org/10.1017/s1461145710001410
44 https://doi.org/10.1073/pnas.0910658107
45 https://doi.org/10.1074/jbc.m206258200
46 https://doi.org/10.1074/jbc.m500814200
47 https://doi.org/10.1091/mbc.e04-05-0438
48 https://doi.org/10.1093/nar/29.4.e21
49 https://doi.org/10.1093/schbul/sbp073
50 https://doi.org/10.1097/yco.0b013e3283436eb7
51 https://doi.org/10.1111/j.1440-1819.2010.02094.x
52 https://doi.org/10.1111/j.1460-9568.2005.04126.x
53 https://doi.org/10.1111/j.1471-4159.2004.03016.x
54 https://doi.org/10.1126/scitranslmed.3002804
55 https://doi.org/10.1146/annurev.immunol.021908.132641
56 https://doi.org/10.1176/appi.ajp.2008.07101562
57 https://doi.org/10.1176/appi.ajp.2008.07101640
58 https://doi.org/10.1371/journal.pbio.0060107
59 https://doi.org/10.1371/journal.pgen.0020190
60 https://doi.org/10.1371/journal.pone.0011351
61 https://doi.org/10.1523/jneurosci.0148-08.2008
62 https://doi.org/10.1523/jneurosci.3566-08.2009
63 https://doi.org/10.1523/jneurosci.4763-10.2011
64 https://doi.org/10.1523/jneurosci.6173-08.2009
65 https://doi.org/10.1534/genetics.107.072819
66 schema:datePublished 2013-02
67 schema:datePublishedReg 2013-02-01
68 schema:description Neurons exhibit a constitutive level of nuclear factor-κB (NF-κB) signaling and this pathway plays a significant role in neurite outgrowth, activity-dependent plasticity, and cognitive function. Transcription factor analysis was performed in a microarray data set profiled in four different brain regions (n=54 comparison group; n=53 schizophrenia (SZ)). An independent postmortem cohort was used for gene expression (n=24 comparison group; n=22 SZ), protein abundance (n=8 comparison group; n=8 SZ), and NF-κB nuclear activity (n=10 comparison group; n=10 SZ) quantification. Expression quantitative trait locus analysis was performed using publicly available data. Prepulse inhibition (PPI) of the acoustic startle reflex was tested in healthy individuals (n=690). Comparison of microarray data showed that NF-κB was among the transcription factors associated with the differential expression of genes in cases vs controls. NF-κB gene and protein levels and nuclear activation were significantly decreased in the superior temporal gyrus of patients with SZ. Upstream NF-κB genes related to translocation were significantly dysregulated in SZ. The gene expression levels of an NF-κB-associated importin (KPNA4: one of the proteins responsible for the translocation of NF-κB to the nucleus) was decreased in SZ and an SNP within the KPNA4 locus was associated with susceptibility to SZ, reduced KPNA4 expression levels and attenuated PPI of the startle reflex in healthy control subjects. These findings implicate abnormalities of the NF-κB signaling pathway in SZ and provide evidence for an additional possible mechanism affecting the translocation of NF-κB signaling to the nucleus.
69 schema:genre research_article
70 schema:inLanguage en
71 schema:isAccessibleForFree true
72 schema:isPartOf Nb584c67c5c614ef9ae9da27ddcadfc2b
73 Nd019289a89ac427584aa2e9c3aaa23d9
74 sg:journal.1099176
75 schema:name Convergent Findings for Abnormalities of the NF-κB Signaling Pathway in Schizophrenia
76 schema:pagination 533
77 schema:productId N382d2ced2b6844cbbb08b7e586155455
78 N6f76dec27aff48e5badb3d96cd29788c
79 N8d8850bf9215498fa464fb5cabdddb5e
80 N9abd006dbfcc44fc8564d4ec4c208119
81 Nc27d3a3b3f4a4d9591fef3c80195cce5
82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017400545
83 https://doi.org/10.1038/npp.2012.215
84 schema:sdDatePublished 2019-04-10T23:13
85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
86 schema:sdPublisher N310f5b4c06034a3f96ad565be34f7c6d
87 schema:url https://www.nature.com/articles/npp2012215
88 sgo:license sg:explorer/license/
89 sgo:sdDataset articles
90 rdf:type schema:ScholarlyArticle
91 N033ba4e57d9949a3807c536ed26fcda3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Cohort Studies
93 rdf:type schema:DefinedTerm
94 N04d514e66c934234bd3138c8dfe40162 rdf:first sg:person.01140360470.23
95 rdf:rest Nd2d458da514f442cb0eb23a49484da85
96 N0a5a4f3756744b459a27af29baaa39a5 rdf:first sg:person.01314014327.88
97 rdf:rest Nf08dc9cf819f45e7b5f5015a92fc466f
98 N310f5b4c06034a3f96ad565be34f7c6d schema:name Springer Nature - SN SciGraph project
99 rdf:type schema:Organization
100 N33ad58b39d524d3bbfcdd00600b9fcce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Temporal Lobe
102 rdf:type schema:DefinedTerm
103 N382d2ced2b6844cbbb08b7e586155455 schema:name readcube_id
104 schema:value 52e7173fb956fc2b263ce79f513288ba9bb980f1293e6312a2a21f124b5aeb77
105 rdf:type schema:PropertyValue
106 N3b530fb103784449a4ec69a4875ab65e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Rats
108 rdf:type schema:DefinedTerm
109 N524cd553b3ee406f99dc3cf6fab6336c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Signal Transduction
111 rdf:type schema:DefinedTerm
112 N5f4027e219764ba6bee8e9a5b44c1ad7 rdf:first sg:person.01323132157.46
113 rdf:rest N645508dd44de4497a7a7a6217e2fe814
114 N645508dd44de4497a7a7a6217e2fe814 rdf:first sg:person.0762766773.09
115 rdf:rest N04d514e66c934234bd3138c8dfe40162
116 N65ebaca6c6ab4ddfa5484440434a567d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Down-Regulation
118 rdf:type schema:DefinedTerm
119 N69ec5684571b4513b84abb295532c0d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name NF-kappa B
121 rdf:type schema:DefinedTerm
122 N6f76dec27aff48e5badb3d96cd29788c schema:name pubmed_id
123 schema:value 23132271
124 rdf:type schema:PropertyValue
125 N7d97a5556eba472eb4ec28daca6f1bd9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Male
127 rdf:type schema:DefinedTerm
128 N85665ce273404a6b89935e4c544cdee6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Rats, Sprague-Dawley
130 rdf:type schema:DefinedTerm
131 N8d8850bf9215498fa464fb5cabdddb5e schema:name dimensions_id
132 schema:value pub.1017400545
133 rdf:type schema:PropertyValue
134 N95eeaee7606944138f8baf09375c1032 rdf:first sg:person.015272745217.30
135 rdf:rest rdf:nil
136 N9816ce122c3e46a4b72f3da4b47700ae rdf:first sg:person.01276534145.69
137 rdf:rest N5f4027e219764ba6bee8e9a5b44c1ad7
138 N9abd006dbfcc44fc8564d4ec4c208119 schema:name doi
139 schema:value 10.1038/npp.2012.215
140 rdf:type schema:PropertyValue
141 Na5372466aeb04b97b52c52cd07278be8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Neural Pathways
143 rdf:type schema:DefinedTerm
144 Nb584c67c5c614ef9ae9da27ddcadfc2b schema:issueNumber 3
145 rdf:type schema:PublicationIssue
146 Nb88385e0468943b09bf688ed52e29bb9 rdf:first sg:person.01230420745.20
147 rdf:rest N0a5a4f3756744b459a27af29baaa39a5
148 Nbf2740e3662340ee9cc21172fc9da7e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Schizophrenia
150 rdf:type schema:DefinedTerm
151 Nc0c8b328f7cb466ba3249ca84cde4543 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Humans
153 rdf:type schema:DefinedTerm
154 Nc27d3a3b3f4a4d9591fef3c80195cce5 schema:name nlm_unique_id
155 schema:value 8904907
156 rdf:type schema:PropertyValue
157 Nc8073fa25ec44512b08f394a91c23096 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Animals
159 rdf:type schema:DefinedTerm
160 Nd019289a89ac427584aa2e9c3aaa23d9 schema:volumeNumber 38
161 rdf:type schema:PublicationVolume
162 Nd2d458da514f442cb0eb23a49484da85 rdf:first sg:person.01333517660.58
163 rdf:rest N95eeaee7606944138f8baf09375c1032
164 Nf08dc9cf819f45e7b5f5015a92fc466f rdf:first sg:person.0604610137.76
165 rdf:rest N9816ce122c3e46a4b72f3da4b47700ae
166 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
167 schema:name Biological Sciences
168 rdf:type schema:DefinedTerm
169 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
170 schema:name Genetics
171 rdf:type schema:DefinedTerm
172 sg:grant.2440944 http://pending.schema.org/fundedItem sg:pub.10.1038/npp.2012.215
173 rdf:type schema:MonetaryGrant
174 sg:grant.2549985 http://pending.schema.org/fundedItem sg:pub.10.1038/npp.2012.215
175 rdf:type schema:MonetaryGrant
176 sg:journal.1099176 schema:issn 0893-133X
177 1740-634X
178 schema:name Neuropsychopharmacology
179 rdf:type schema:Periodical
180 sg:person.01140360470.23 schema:familyName Siever
181 schema:givenName Larry J
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140360470.23
183 rdf:type schema:Person
184 sg:person.01230420745.20 schema:affiliation https://www.grid.ac/institutes/grid.59734.3c
185 schema:familyName Roussos
186 schema:givenName Panos
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230420745.20
188 rdf:type schema:Person
189 sg:person.01276534145.69 schema:familyName Giakoumaki
190 schema:givenName Stella G
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276534145.69
192 rdf:type schema:Person
193 sg:person.01314014327.88 schema:familyName Katsel
194 schema:givenName Pavel
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314014327.88
196 rdf:type schema:Person
197 sg:person.01323132157.46 schema:familyName Lencz
198 schema:givenName Todd
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323132157.46
200 rdf:type schema:Person
201 sg:person.01333517660.58 schema:familyName Bitsios
202 schema:givenName Panos
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333517660.58
204 rdf:type schema:Person
205 sg:person.015272745217.30 schema:familyName Haroutunian
206 schema:givenName Vahram
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015272745217.30
208 rdf:type schema:Person
209 sg:person.0604610137.76 schema:familyName Davis
210 schema:givenName Kenneth L
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604610137.76
212 rdf:type schema:Person
213 sg:person.0762766773.09 schema:familyName Malhotra
214 schema:givenName Anil K
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762766773.09
216 rdf:type schema:Person
217 sg:pub.10.1016/s0893-133x(01)00364-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028903414
218 https://doi.org/10.1016/s0893-133x(01)00364-5
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/nature10524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044236818
221 https://doi.org/10.1038/nature10524
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/ng.940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053172161
224 https://doi.org/10.1038/ng.940
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/ng1847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031429813
227 https://doi.org/10.1038/ng1847
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/nn995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004743482
230 https://doi.org/10.1038/nn995
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/npp.2011.49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014063466
233 https://doi.org/10.1038/npp.2011.49
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/npp.2011.78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007552066
236 https://doi.org/10.1038/npp.2011.78
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/nrm2083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041332849
239 https://doi.org/10.1038/nrm2083
240 rdf:type schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1074669255 schema:CreativeWork
242 https://doi.org/10.1001/archgenpsychiatry.2011.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025191600
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1001/archgenpsychiatry.2012.704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051429391
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1001/archpsyc.59.8.686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049582727
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1002/jnr.20702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027948281
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.biopsych.2008.01.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027357488
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.biopsych.2008.10.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002447922
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.biopsych.2009.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041237311
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.biopsych.2010.09.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034294369
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.biopsych.2011.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033105090
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.ejphar.2008.06.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025093048
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.euroneuro.2006.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014003329
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.mcn.2008.01.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035260695
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.mcn.2010.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047672473
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.neuron.2010.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002208651
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.pnpbp.2008.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013735690
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.semcdb.2009.04.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018175107
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/j.tins.2011.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033079594
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1017/s0033291708002912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054037092
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1017/s1461145710001410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028025116
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1073/pnas.0910658107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020845578
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1074/jbc.m206258200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013047608
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1074/jbc.m500814200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013565275
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1091/mbc.e04-05-0438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001721374
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1093/nar/29.4.e21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001294215
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1093/schbul/sbp073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027598488
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1097/yco.0b013e3283436eb7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046331296
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1111/j.1440-1819.2010.02094.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043282915
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1111/j.1460-9568.2005.04126.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002636533
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1111/j.1471-4159.2004.03016.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027498255
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1126/scitranslmed.3002804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062687173
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1146/annurev.immunol.021908.132641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043156499
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1176/appi.ajp.2008.07101562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063498098
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1176/appi.ajp.2008.07101640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063498102
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1371/journal.pbio.0060107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033670612
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1371/journal.pgen.0020190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029170965
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1371/journal.pone.0011351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019942982
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1523/jneurosci.0148-08.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022249481
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1523/jneurosci.3566-08.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003566829
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1523/jneurosci.4763-10.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006794118
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1523/jneurosci.6173-08.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047542479
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1534/genetics.107.072819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020858268
323 rdf:type schema:CreativeWork
324 https://www.grid.ac/institutes/grid.59734.3c schema:alternateName Icahn School of Medicine at Mount Sinai
325 schema:name Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY 10468, USA.
326 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...