Unique cell-type-specific patterns of DNA methylation in the root meristem View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-04-29

AUTHORS

Taiji Kawakatsu, Tim Stuart, Manuel Valdes, Natalie Breakfield, Robert J. Schmitz, Joseph R. Nery, Mark A. Urich, Xinwei Han, Ryan Lister, Philip N. Benfey, Joseph R. Ecker

ABSTRACT

DNA methylation is an epigenetic modification that differs between plant organs and tissues, but the extent of variation between cell types is not known. Here, we report single-base-resolution whole-genome DNA methylomes, mRNA transcriptomes and small RNA transcriptomes for six cell populations covering the major cell types of the Arabidopsis root meristem. We identify widespread cell-type-specific patterns of DNA methylation, especially in the CHH sequence context, where H is A, C or T. The genome of the columella root cap is the most highly methylated Arabidopsis cell characterized so far. It is hypermethylated within transposable elements (TEs), accompanied by increased abundance of transcripts encoding RNA-directed DNA methylation (RdDM) pathway components and 24-nt small RNAs (smRNAs). The absence of the nucleosome remodeller DECREASED DNA METHYLATION 1 (DDM1), required for maintenance of DNA methylation, and low abundance of histone transcripts involved in heterochromatin formation suggests that a loss of heterochromatin may occur in the columella, thus allowing access of RdDM factors to the whole genome, and producing an excess of 24-nt smRNAs in this tissue. Together, these maps provide new insights into the epigenomic diversity that exists between distinct plant somatic cell types. More... »

PAGES

nplants201658

References to SciGraph publications

  • 2011-03. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells in NATURE
  • 2014-01. Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2013-03. Patterns of population epigenomic diversity in NATURE
  • 1999-09. An epigenetic mutation responsible for natural variation in floral symmetry in NATURE
  • 2009-09. Selective epigenetic control of retrotransposition in Arabidopsis in NATURE
  • 2014-06. RNA-directed DNA methylation: an epigenetic pathway of increasing complexity in NATURE REVIEWS GENETICS
  • 2009-09. Bursts of retrotransposition reproduced in Arabidopsis in NATURE
  • 2015-07. Human body epigenome maps reveal noncanonical DNA methylation variation in NATURE
  • 2013-04. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions in GENOME BIOLOGY
  • 2009-11. Human DNA methylomes at base resolution show widespread epigenomic differences in NATURE
  • 2015-03. MethylC-seq library preparation for base-resolution whole-genome bisulfite sequencing in NATURE PROTOCOLS
  • 2005-11. Root gravitropism requires lateral root cap and epidermal cells for transport and response to a mobile auxin signal in NATURE CELL BIOLOGY
  • 2010-06-28. Fluorescence-Activated Cell Sorting in Plant Developmental Biology in PLANT DEVELOPMENTAL BIOLOGY
  • 2011-12. Spontaneous epigenetic variation in the Arabidopsis thaliana methylome in NATURE
  • 2010-03. Establishing, maintaining and modifying DNA methylation patterns in plants and animals in NATURE REVIEWS GENETICS
  • 2006-06. Dissecting Arabidopsis thaliana DICER function in small RNA processing, gene silencing and DNA methylation patterning in NATURE GENETICS
  • 2007-01. Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription in NATURE GENETICS
  • 2012-03-01. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks in NATURE PROTOCOLS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nplants.2016.58

    DOI

    http://dx.doi.org/10.1038/nplants.2016.58

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1037282071

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27243651


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