PRC2 represses dedifferentiation of mature somatic cells in Arabidopsis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-06-29

AUTHORS

Momoko Ikeuchi, Akira Iwase, Bart Rymen, Hirofumi Harashima, Michitaro Shibata, Mariko Ohnuma, Christian Breuer, Ana Karina Morao, Miguel de Lucas, Lieven De Veylder, Justin Goodrich, Siobhan M. Brady, François Roudier, Keiko Sugimoto

ABSTRACT

Plant somatic cells are generally acknowledged to retain totipotency, the potential to develop into any cell type within an organism. This astonishing plasticity may contribute to a high regenerative capacity on severe damage, but how plants control this potential during normal post-embryonic development remains largely unknown1,2. Here we show that POLYCOMB REPRESSIVE COMPLEX 2 (PRC2), a chromatin regulator that maintains gene repression through histone modification, prevents dedifferentiation of mature somatic cells in Arabidopsis thaliana roots. Loss-of-function mutants in PRC2 subunits initially develop unicellular root hairs indistinguishable from those in wild type but fail to retain the differentiated state, ultimately resulting in the generation of an unorganized cell mass and somatic embryos from a single root hair. Strikingly, mutant root hairs complete the normal endoreduplication programme, increasing their nuclear ploidy, but subsequently reinitiate mitotic division coupled with successive DNA replication. Our data show that the WOUND INDUCED DEDIFFERENTIATION3 (WIND3) and LEAFY COTYLEDON2 (LEC2) genes are among the PRC2 targets involved in this reprogramming, as their ectopic overexpression partly phenocopies the dedifferentiation phenotype of PRC2 mutants. These findings unveil the pivotal role of PRC2-mediated gene repression in preventing unscheduled reprogramming of fully differentiated plant cells. More... »

PAGES

15089

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nplants.2015.89

DOI

http://dx.doi.org/10.1038/nplants.2015.89

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028126267

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27250255


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61 modification
62 mutant root hairs
63 mutants
64 normal endoreduplication programme
65 normal post-embryonic development
66 nuclear ploidy
67 organisms
68 overexpression
69 phenotype
70 pivotal role
71 plant cells
72 plant somatic cells
73 plants
74 plasticity
75 ploidy
76 post-embryonic development
77 potential
78 prevents dedifferentiation
79 program
80 regenerative capacity
81 regulator
82 replication
83 repression
84 reprogramming
85 role
86 root hairs
87 roots
88 severe damage
89 single root hair
90 somatic cells
91 somatic embryos
92 state
93 subunits
94 successive DNA replication
95 target
96 thaliana roots
97 totipotency
98 types
99 unicellular root hairs
100 unorganized cell mass
101 unscheduled reprogramming
102 wild type
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