Chromatin assembly factor CAF-1 represses priming of plant defence response genes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-09-01

AUTHORS

Iva Mozgová, Thomas Wildhaber, Qinsong Liu, Eliane Abou-Mansour, Floriane L'Haridon, Jean-Pierre Métraux, Wilhelm Gruissem, Daniel Hofius, Lars Hennig

ABSTRACT

Plants have evolved efficient defence systems against pathogens that often rely on specific transcriptional responses. Priming is part of the defence syndrome, by establishing a hypersensitive state of defence genes such as after a first encounter with a pathogen. Because activation of defence responses has a fitness cost, priming must be tightly controlled to prevent spurious activation of defence. However, mechanisms that repress defence gene priming are poorly understood. Here, we show that the histone chaperone CAF-1 is required to establish a repressed chromatin state at defence genes. Absence of CAF-1 results in spurious activation of a salicylic acid-dependent pathogen defence response in plants grown under non-sterile conditions. Chromatin at defence response genes in CAF-1 mutants under non-inductive (sterile) conditions is marked by low nucleosome occupancy and high H3K4me3 at transcription start sites, resembling chromatin in primed wild-type plants. We conclude that CAF-1-mediated chromatin assembly prevents the establishment of a primed state that may under standard non-sterile growth conditions result in spurious activation of SA-dependent defence responses and consequential reduction of plant vigour. More... »

PAGES

15127

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nplants.2015.127

DOI

http://dx.doi.org/10.1038/nplants.2015.127

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010574471

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27250680


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nplants.2015.127'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nplants.2015.127'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nplants.2015.127'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nplants.2015.127'


 

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