Prevalence and predictors of androgen receptor and programmed death-ligand 1 in BRCA1-associated and sporadic triple-negative breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Nadine Tung, Judy E Garber, Michele R Hacker, Vanda Torous, Gordon J Freeman, Emily Poles, Scott Rodig, Brian Alexander, Larissa Lee, Laura C Collins, Stuart J Schnitt

ABSTRACT

BACKGROUND: Triple-negative breast cancers comprise 15% of breast cancers and are more common in women with BRCA1 mutations. Although most have basal gene expression signatures, others resemble luminal tumors with expression of androgen receptor-related genes and some express the immunoinhibitory protein programmed death-ligand 1 (PD-L1). Given the availability of androgen receptor-targeted and immune therapies for triple-negative breast cancers, determining predictors of these biomarkers is important. AIMS: To determine the prevalence and predictors of androgen receptor and PD-L1 expression in BRCA1-associated and sporadic triple-negative breast cancer. METHODS: We studied 197 triple-negative breast cancers: 78 (39.6%) from BRCA1 mutation carriers and 119 (60.4%) from noncarriers. Tumor pathology was reviewed and tissue microarray sections were immunostained for androgen receptor and PD-L1. RESULTS: Androgen receptor expression was seen in 18% of tumors and was significantly less common in tumors from BRCA1 mutation carriers than noncarriers (9.2 vs. 23.7%; P=0.01). Twenty-six percent of cancers expressed PD-L1 with no significant difference in frequency between carriers and noncarriers. Factors predicting androgen receptor expression were lower histologic grade (odds ratio (OR) 4.6; 95% confidence interval (CI) 1.1-19.7), older age at diagnosis (OR 1.3; 95% CI 1.03-1.7) and PD-L1 expression (OR 2.6; 95% CI 1.1-6.1). PD-L1 expression was significantly more common in cancers with lymphocytic infiltrates (OR, 3.3; 95% CI 1.1-10.4) and androgen receptor expression (OR, 3.2; 95% CI 1.4-7.5), and less common in tumors with lymphovascular invasion (OR 0.41; 95% CI 0.18-0.92). CONCLUSIONS: These results identify predictors for androgen receptor and PD-L1 expression among triple-negative breast cancers that may lead to better treatment selection and participation in clinical trials. More... »

PAGES

16002

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/npjbcancer.2016.2

DOI

http://dx.doi.org/10.1038/npjbcancer.2016.2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028459257

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28721372


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    "description": "BACKGROUND: Triple-negative breast cancers comprise 15% of breast cancers and are more common in women with BRCA1 mutations. Although most have basal gene expression signatures, others resemble luminal tumors with expression of androgen receptor-related genes and some express the immunoinhibitory protein programmed death-ligand 1 (PD-L1). Given the availability of androgen receptor-targeted and immune therapies for triple-negative breast cancers, determining predictors of these biomarkers is important.\nAIMS: To determine the prevalence and predictors of androgen receptor and PD-L1 expression in BRCA1-associated and sporadic triple-negative breast cancer.\nMETHODS: We studied 197 triple-negative breast cancers: 78 (39.6%) from BRCA1 mutation carriers and 119 (60.4%) from noncarriers. Tumor pathology was reviewed and tissue microarray sections were immunostained for androgen receptor and PD-L1.\nRESULTS: Androgen receptor expression was seen in 18% of tumors and was significantly less common in tumors from BRCA1 mutation carriers than noncarriers (9.2 vs. 23.7%; P=0.01). Twenty-six percent of cancers expressed PD-L1 with no significant difference in frequency between carriers and noncarriers. Factors predicting androgen receptor expression were lower histologic grade (odds ratio (OR) 4.6; 95% confidence interval (CI) 1.1-19.7), older age at diagnosis (OR 1.3; 95% CI 1.03-1.7) and PD-L1 expression (OR 2.6; 95% CI 1.1-6.1). PD-L1 expression was significantly more common in cancers with lymphocytic infiltrates (OR, 3.3; 95% CI 1.1-10.4) and androgen receptor expression (OR, 3.2; 95% CI 1.4-7.5), and less common in tumors with lymphovascular invasion (OR 0.41; 95% CI 0.18-0.92).\nCONCLUSIONS: These results identify predictors for androgen receptor and PD-L1 expression among triple-negative breast cancers that may lead to better treatment selection and participation in clinical trials.", 
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278 schema:name Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
279 Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
280 Division of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA.
281 Harvard Medical School, Boston, MA, USA.
282 rdf:type schema:Organization
 




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