Somatic mutations in leukocytes infiltrating primary breast cancers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-11

AUTHORS

Maria Kleppe, Elizabeth Comen, Hannah Y Wen, Lennart Bastian, Brian Blum, Franck T Rapaport, Matthew Keller, Zvika Granot, Nicolas Socci, Agnès Viale, Daoqi You, Robert Benezra, Britta Weigelt, Edi Brogi, Michael F Berger, Jorge S Reis-Filho, Ross L Levine, Larry Norton

ABSTRACT

BACKGROUND: Malignant transformation requires the interaction of cancer cells with their microenvironment, including infiltrating leukocytes. However, somatic mutational studies have focused on alterations in cancer cells, assuming that the microenvironment is genetically normal. Because we hypothesized that this might not be a valid assumption, we performed exome sequencing and targeted sequencing to investigate for the presence of pathogenic mutations in tumor-associated leukocytes in breast cancers. METHODS: We used targeted sequencing and exome sequencing to evaluate the presence of mutations in sorted tumor-infiltrating CD45-positive cells from primary untreated breast cancers. We used high-depth sequencing to determine the presence/absence of the mutations we identified in breast cancer-infiltrating leukocytes in purified tumor cells and in circulating blood cells. RESULTS: Capture-based sequencing of 15 paired tumor-infiltrating leukocytes and matched germline DNA identified variants in known cancer genes in all 15 primary breast cancer patients in our cohort. We validated the presence of mutations identified by targeted sequencing in infiltrating leukocytes through orthogonal exome sequencing. Ten patients harbored alterations previously reported as somatically acquired variants, including in known leukemia genes (DNTM3A, TET2, and BCOR). One of the mutations observed in the tumor-infiltrating leukocytes was also detected in the circulating leukocytes of the same patients at a lower allele frequency than observed in the tumor-infiltrating cells. CONCLUSIONS: Here we show that somatic mutations, including mutations in known cancer genes, are present in the leukocytes infiltrating a subset of primary breast cancers. This observation allows for the possibility that the cancer cells interact with mutant infiltrating leukocytes, which has many potential clinical implications. More... »

PAGES

15005

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/npjbcancer.2015.5

DOI

http://dx.doi.org/10.1038/npjbcancer.2015.5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040550004

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28721364


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kleppe", 
        "givenName": "Maria", 
        "id": "sg:person.01061033102.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061033102.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Breast Cancer Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Comen", 
        "givenName": "Elizabeth", 
        "id": "sg:person.0620711551.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620711551.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wen", 
        "givenName": "Hannah Y", 
        "id": "sg:person.0761552424.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761552424.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bastian", 
        "givenName": "Lennart", 
        "id": "sg:person.01104311664.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104311664.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Breast Cancer Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blum", 
        "givenName": "Brian", 
        "id": "sg:person.013165122253.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013165122253.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "The Bioinformatics Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rapaport", 
        "givenName": "Franck T", 
        "id": "sg:person.01065554550.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065554550.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Keller", 
        "givenName": "Matthew", 
        "id": "sg:person.0717743404.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717743404.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Granot", 
        "givenName": "Zvika", 
        "id": "sg:person.010006030663.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010006030663.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "The Bioinformatics Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Socci", 
        "givenName": "Nicolas", 
        "id": "sg:person.010357032237.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010357032237.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "The Genomics Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Viale", 
        "givenName": "Agn\u00e8s", 
        "id": "sg:person.0712021032.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712021032.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "The Genomics Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "You", 
        "givenName": "Daoqi", 
        "id": "sg:person.015261612501.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015261612501.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benezra", 
        "givenName": "Robert", 
        "id": "sg:person.0674175575.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674175575.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA", 
            "Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weigelt", 
        "givenName": "Britta", 
        "id": "sg:person.01364124146.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364124146.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brogi", 
        "givenName": "Edi", 
        "id": "sg:person.0645453013.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645453013.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA", 
            "Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berger", 
        "givenName": "Michael F", 
        "id": "sg:person.0653777340.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653777340.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA", 
            "Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reis-Filho", 
        "givenName": "Jorge S", 
        "id": "sg:person.01045625165.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045625165.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA", 
            "Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Levine", 
        "givenName": "Ross L", 
        "id": "sg:person.01004503566.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004503566.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Breast Cancer Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Norton", 
        "givenName": "Larry", 
        "id": "sg:person.0750405610.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750405610.87"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature11143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000834660", 
          "https://doi.org/10.1038/nature11143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1226344", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001422456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.2581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008422607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.2581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008422607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1596", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009581629", 
          "https://doi.org/10.1038/ng1596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1596", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009581629", 
          "https://doi.org/10.1038/ng1596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2013.493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011873073", 
          "https://doi.org/10.1038/bjc.2013.493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012926250", 
          "https://doi.org/10.1038/nm.3733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.04.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014843210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2010.01.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016166048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.25.6529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016721540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2011.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017224423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2011.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018476707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.41.0902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021750149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2013.55.0491", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023387220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2011.08.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024168378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024942368", 
          "https://doi.org/10.1038/nature11412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2004.06.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026497881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4084/mjhid.2011.069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028094694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2013.50.9984", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028197158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.30.5037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032062887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.107524.110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032096953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2413", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032784004", 
          "https://doi.org/10.1038/ng.2413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-12-0101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032792038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033012733", 
          "https://doi.org/10.1038/ng1013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033012733", 
          "https://doi.org/10.1038/ng1013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2013.54.6119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034900652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1408617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037067588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btp324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038266369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1112317108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041424096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046203017", 
          "https://doi.org/10.1038/nature06188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/imt.13.166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050213377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.5.15.3112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072298542"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-11", 
    "datePublishedReg": "2015-11-01", 
    "description": "BACKGROUND: Malignant transformation requires the interaction of cancer cells with their microenvironment, including infiltrating leukocytes. However, somatic mutational studies have focused on alterations in cancer cells, assuming that the microenvironment is genetically normal. Because we hypothesized that this might not be a valid assumption, we performed exome sequencing and targeted sequencing to investigate for the presence of pathogenic mutations in tumor-associated leukocytes in breast cancers.\nMETHODS: We used targeted sequencing and exome sequencing to evaluate the presence of mutations in sorted tumor-infiltrating CD45-positive cells from primary untreated breast cancers. We used high-depth sequencing to determine the presence/absence of the mutations we identified in breast cancer-infiltrating leukocytes in purified tumor cells and in circulating blood cells.\nRESULTS: Capture-based sequencing of 15 paired tumor-infiltrating leukocytes and matched germline DNA identified variants in known cancer genes in all 15 primary breast cancer patients in our cohort. We validated the presence of mutations identified by targeted sequencing in infiltrating leukocytes through orthogonal exome sequencing. Ten patients harbored alterations previously reported as somatically acquired variants, including in known leukemia genes (DNTM3A, TET2, and BCOR). One of the mutations observed in the tumor-infiltrating leukocytes was also detected in the circulating leukocytes of the same patients at a lower allele frequency than observed in the tumor-infiltrating cells.\nCONCLUSIONS: Here we show that somatic mutations, including mutations in known cancer genes, are present in the leukocytes infiltrating a subset of primary breast cancers. This observation allows for the possibility that the cancer cells interact with mutant infiltrating leukocytes, which has many potential clinical implications.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/npjbcancer.2015.5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2480997", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1052988", 
        "issn": [
          "2374-4677"
        ], 
        "name": "npj Breast Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "1"
      }
    ], 
    "name": "Somatic mutations in leukocytes infiltrating primary breast cancers", 
    "pagination": "15005", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c12a31dc194f9a7d1047ecfdfb3cd8bfbf5c86893859adee73c48f17532f3b58"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28721364"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101674891"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/npjbcancer.2015.5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1040550004"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/npjbcancer.2015.5", 
      "https://app.dimensions.ai/details/publication/pub.1040550004"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/npjbcancer20155"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/npjbcancer.2015.5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/npjbcancer.2015.5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/npjbcancer.2015.5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/npjbcancer.2015.5'


 

This table displays all metadata directly associated to this object as RDF triples.

293 TRIPLES      21 PREDICATES      59 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/npjbcancer.2015.5 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nba7137aa62ea4194870adb606017bae9
4 schema:citation sg:pub.10.1038/bjc.2013.493
5 sg:pub.10.1038/nature06188
6 sg:pub.10.1038/nature11143
7 sg:pub.10.1038/nature11412
8 sg:pub.10.1038/ng.2413
9 sg:pub.10.1038/ng1013
10 sg:pub.10.1038/ng1596
11 sg:pub.10.1038/nm.3733
12 https://doi.org/10.1002/path.2581
13 https://doi.org/10.1016/j.ccr.2004.06.010
14 https://doi.org/10.1016/j.ccr.2011.06.001
15 https://doi.org/10.1016/j.ccr.2011.06.003
16 https://doi.org/10.1016/j.ccr.2011.08.012
17 https://doi.org/10.1016/j.cell.2010.01.025
18 https://doi.org/10.1016/j.cell.2012.04.042
19 https://doi.org/10.1056/nejmoa1408617
20 https://doi.org/10.1073/pnas.1112317108
21 https://doi.org/10.1093/bioinformatics/btp324
22 https://doi.org/10.1101/gr.107524.110
23 https://doi.org/10.1126/science.1226344
24 https://doi.org/10.1158/2159-8290.cd-12-0101
25 https://doi.org/10.1200/jco.2009.25.6529
26 https://doi.org/10.1200/jco.2010.30.5037
27 https://doi.org/10.1200/jco.2011.41.0902
28 https://doi.org/10.1200/jco.2013.50.9984
29 https://doi.org/10.1200/jco.2013.54.6119
30 https://doi.org/10.1200/jco.2013.55.0491
31 https://doi.org/10.2217/imt.13.166
32 https://doi.org/10.4084/mjhid.2011.069
33 https://doi.org/10.4161/cc.5.15.3112
34 schema:datePublished 2015-11
35 schema:datePublishedReg 2015-11-01
36 schema:description BACKGROUND: Malignant transformation requires the interaction of cancer cells with their microenvironment, including infiltrating leukocytes. However, somatic mutational studies have focused on alterations in cancer cells, assuming that the microenvironment is genetically normal. Because we hypothesized that this might not be a valid assumption, we performed exome sequencing and targeted sequencing to investigate for the presence of pathogenic mutations in tumor-associated leukocytes in breast cancers. METHODS: We used targeted sequencing and exome sequencing to evaluate the presence of mutations in sorted tumor-infiltrating CD45-positive cells from primary untreated breast cancers. We used high-depth sequencing to determine the presence/absence of the mutations we identified in breast cancer-infiltrating leukocytes in purified tumor cells and in circulating blood cells. RESULTS: Capture-based sequencing of 15 paired tumor-infiltrating leukocytes and matched germline DNA identified variants in known cancer genes in all 15 primary breast cancer patients in our cohort. We validated the presence of mutations identified by targeted sequencing in infiltrating leukocytes through orthogonal exome sequencing. Ten patients harbored alterations previously reported as somatically acquired variants, including in known leukemia genes (DNTM3A, TET2, and BCOR). One of the mutations observed in the tumor-infiltrating leukocytes was also detected in the circulating leukocytes of the same patients at a lower allele frequency than observed in the tumor-infiltrating cells. CONCLUSIONS: Here we show that somatic mutations, including mutations in known cancer genes, are present in the leukocytes infiltrating a subset of primary breast cancers. This observation allows for the possibility that the cancer cells interact with mutant infiltrating leukocytes, which has many potential clinical implications.
37 schema:genre research_article
38 schema:inLanguage en
39 schema:isAccessibleForFree true
40 schema:isPartOf N91073af7d92b4738b3cba3b857c8a95e
41 Ned597ffca2a6436baa866d24ee4917b5
42 sg:journal.1052988
43 schema:name Somatic mutations in leukocytes infiltrating primary breast cancers
44 schema:pagination 15005
45 schema:productId N83a38fdd3814437f89e6f898e3c3cd64
46 N88e5e6fd3dac4e399900bb48373cec98
47 Nc262f0a4293b401693a33a24ab837eb9
48 Nd945d31f790448d4a800021829095acf
49 Nf0050598c1df4e87aabf94da23d84265
50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040550004
51 https://doi.org/10.1038/npjbcancer.2015.5
52 schema:sdDatePublished 2019-04-10T14:48
53 schema:sdLicense https://scigraph.springernature.com/explorer/license/
54 schema:sdPublisher N8e4e67ac47cf464c8089576aa16a5797
55 schema:url http://www.nature.com/articles/npjbcancer20155
56 sgo:license sg:explorer/license/
57 sgo:sdDataset articles
58 rdf:type schema:ScholarlyArticle
59 N045d987d5c31405ba1db28775fd5b819 rdf:first sg:person.01004503566.84
60 rdf:rest N7424531dfddc4e8ca2fc3a339040c405
61 N0edcc07ec4d642519044884ad9ca6456 rdf:first sg:person.01364124146.08
62 rdf:rest Ndb214fe47b2b44afbec25dfc5e5c025c
63 N1701c99d411347298812b2182d41ec4c rdf:first sg:person.013165122253.27
64 rdf:rest Nadb05e11e1af4f5785b4f586f37f9169
65 N1abe481543c747fba8eb05431ad7264a rdf:first sg:person.01045625165.06
66 rdf:rest N045d987d5c31405ba1db28775fd5b819
67 N1eb0c335e53048538095552db345838e rdf:first sg:person.0761552424.06
68 rdf:rest Nf6464292f77842cf8faac65290aa32de
69 N317239db5fbe47d995dc0022003cb459 rdf:first sg:person.010006030663.30
70 rdf:rest N8e668af4790548298381d4c2c59f68df
71 N3ac24679716a42bd953851a605fbc109 rdf:first sg:person.015261612501.78
72 rdf:rest N72bce862ef23432097377e04f61241ab
73 N56042fff8f16406ea46dc04b472d6fdf rdf:first sg:person.0620711551.21
74 rdf:rest N1eb0c335e53048538095552db345838e
75 N637b14d834b94a7393ef8cddb64d61d8 rdf:first sg:person.0653777340.46
76 rdf:rest N1abe481543c747fba8eb05431ad7264a
77 N72bce862ef23432097377e04f61241ab rdf:first sg:person.0674175575.90
78 rdf:rest N0edcc07ec4d642519044884ad9ca6456
79 N7424531dfddc4e8ca2fc3a339040c405 rdf:first sg:person.0750405610.87
80 rdf:rest rdf:nil
81 N83a38fdd3814437f89e6f898e3c3cd64 schema:name nlm_unique_id
82 schema:value 101674891
83 rdf:type schema:PropertyValue
84 N88e5e6fd3dac4e399900bb48373cec98 schema:name readcube_id
85 schema:value c12a31dc194f9a7d1047ecfdfb3cd8bfbf5c86893859adee73c48f17532f3b58
86 rdf:type schema:PropertyValue
87 N8e4e67ac47cf464c8089576aa16a5797 schema:name Springer Nature - SN SciGraph project
88 rdf:type schema:Organization
89 N8e668af4790548298381d4c2c59f68df rdf:first sg:person.010357032237.05
90 rdf:rest Nec02a5954ace4bd594d141a9e5561dc6
91 N91073af7d92b4738b3cba3b857c8a95e schema:volumeNumber 1
92 rdf:type schema:PublicationVolume
93 Na2c95dc8b9564eb2a4749add7c45a19a rdf:first sg:person.0717743404.61
94 rdf:rest N317239db5fbe47d995dc0022003cb459
95 Nadb05e11e1af4f5785b4f586f37f9169 rdf:first sg:person.01065554550.96
96 rdf:rest Na2c95dc8b9564eb2a4749add7c45a19a
97 Nba7137aa62ea4194870adb606017bae9 rdf:first sg:person.01061033102.06
98 rdf:rest N56042fff8f16406ea46dc04b472d6fdf
99 Nc262f0a4293b401693a33a24ab837eb9 schema:name doi
100 schema:value 10.1038/npjbcancer.2015.5
101 rdf:type schema:PropertyValue
102 Nd945d31f790448d4a800021829095acf schema:name pubmed_id
103 schema:value 28721364
104 rdf:type schema:PropertyValue
105 Ndb214fe47b2b44afbec25dfc5e5c025c rdf:first sg:person.0645453013.49
106 rdf:rest N637b14d834b94a7393ef8cddb64d61d8
107 Nec02a5954ace4bd594d141a9e5561dc6 rdf:first sg:person.0712021032.88
108 rdf:rest N3ac24679716a42bd953851a605fbc109
109 Ned597ffca2a6436baa866d24ee4917b5 schema:issueNumber 1
110 rdf:type schema:PublicationIssue
111 Nf0050598c1df4e87aabf94da23d84265 schema:name dimensions_id
112 schema:value pub.1040550004
113 rdf:type schema:PropertyValue
114 Nf6464292f77842cf8faac65290aa32de rdf:first sg:person.01104311664.41
115 rdf:rest N1701c99d411347298812b2182d41ec4c
116 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
117 schema:name Medical and Health Sciences
118 rdf:type schema:DefinedTerm
119 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
120 schema:name Oncology and Carcinogenesis
121 rdf:type schema:DefinedTerm
122 sg:grant.2480997 http://pending.schema.org/fundedItem sg:pub.10.1038/npjbcancer.2015.5
123 rdf:type schema:MonetaryGrant
124 sg:journal.1052988 schema:issn 2374-4677
125 schema:name npj Breast Cancer
126 rdf:type schema:Periodical
127 sg:person.010006030663.30 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
128 schema:familyName Granot
129 schema:givenName Zvika
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010006030663.30
131 rdf:type schema:Person
132 sg:person.01004503566.84 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
133 schema:familyName Levine
134 schema:givenName Ross L
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004503566.84
136 rdf:type schema:Person
137 sg:person.010357032237.05 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
138 schema:familyName Socci
139 schema:givenName Nicolas
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010357032237.05
141 rdf:type schema:Person
142 sg:person.01045625165.06 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
143 schema:familyName Reis-Filho
144 schema:givenName Jorge S
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045625165.06
146 rdf:type schema:Person
147 sg:person.01061033102.06 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
148 schema:familyName Kleppe
149 schema:givenName Maria
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061033102.06
151 rdf:type schema:Person
152 sg:person.01065554550.96 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
153 schema:familyName Rapaport
154 schema:givenName Franck T
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065554550.96
156 rdf:type schema:Person
157 sg:person.01104311664.41 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
158 schema:familyName Bastian
159 schema:givenName Lennart
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104311664.41
161 rdf:type schema:Person
162 sg:person.013165122253.27 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
163 schema:familyName Blum
164 schema:givenName Brian
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013165122253.27
166 rdf:type schema:Person
167 sg:person.01364124146.08 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
168 schema:familyName Weigelt
169 schema:givenName Britta
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364124146.08
171 rdf:type schema:Person
172 sg:person.015261612501.78 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
173 schema:familyName You
174 schema:givenName Daoqi
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015261612501.78
176 rdf:type schema:Person
177 sg:person.0620711551.21 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
178 schema:familyName Comen
179 schema:givenName Elizabeth
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620711551.21
181 rdf:type schema:Person
182 sg:person.0645453013.49 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
183 schema:familyName Brogi
184 schema:givenName Edi
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645453013.49
186 rdf:type schema:Person
187 sg:person.0653777340.46 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
188 schema:familyName Berger
189 schema:givenName Michael F
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653777340.46
191 rdf:type schema:Person
192 sg:person.0674175575.90 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
193 schema:familyName Benezra
194 schema:givenName Robert
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674175575.90
196 rdf:type schema:Person
197 sg:person.0712021032.88 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
198 schema:familyName Viale
199 schema:givenName Agnès
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712021032.88
201 rdf:type schema:Person
202 sg:person.0717743404.61 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
203 schema:familyName Keller
204 schema:givenName Matthew
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717743404.61
206 rdf:type schema:Person
207 sg:person.0750405610.87 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
208 schema:familyName Norton
209 schema:givenName Larry
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750405610.87
211 rdf:type schema:Person
212 sg:person.0761552424.06 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
213 schema:familyName Wen
214 schema:givenName Hannah Y
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761552424.06
216 rdf:type schema:Person
217 sg:pub.10.1038/bjc.2013.493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011873073
218 https://doi.org/10.1038/bjc.2013.493
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/nature06188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046203017
221 https://doi.org/10.1038/nature06188
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/nature11143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000834660
224 https://doi.org/10.1038/nature11143
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/nature11412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024942368
227 https://doi.org/10.1038/nature11412
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/ng.2413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032784004
230 https://doi.org/10.1038/ng.2413
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/ng1013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033012733
233 https://doi.org/10.1038/ng1013
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/ng1596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009581629
236 https://doi.org/10.1038/ng1596
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/nm.3733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012926250
239 https://doi.org/10.1038/nm.3733
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1002/path.2581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008422607
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/j.ccr.2004.06.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026497881
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/j.ccr.2011.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018476707
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/j.ccr.2011.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017224423
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/j.ccr.2011.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024168378
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/j.cell.2010.01.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016166048
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/j.cell.2012.04.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014843210
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1056/nejmoa1408617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037067588
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1073/pnas.1112317108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041424096
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1093/bioinformatics/btp324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038266369
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1101/gr.107524.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032096953
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1126/science.1226344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001422456
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1158/2159-8290.cd-12-0101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032792038
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1200/jco.2009.25.6529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016721540
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1200/jco.2010.30.5037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032062887
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1200/jco.2011.41.0902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021750149
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1200/jco.2013.50.9984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028197158
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1200/jco.2013.54.6119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034900652
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1200/jco.2013.55.0491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023387220
278 rdf:type schema:CreativeWork
279 https://doi.org/10.2217/imt.13.166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050213377
280 rdf:type schema:CreativeWork
281 https://doi.org/10.4084/mjhid.2011.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028094694
282 rdf:type schema:CreativeWork
283 https://doi.org/10.4161/cc.5.15.3112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298542
284 rdf:type schema:CreativeWork
285 https://www.grid.ac/institutes/grid.51462.34 schema:alternateName Memorial Sloan Kettering Cancer Center
286 schema:name Breast Cancer Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
287 Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
288 Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
289 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
290 Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
291 The Bioinformatics Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA
292 The Genomics Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA
293 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...