Real-time in vivo computed optical interferometric tomography View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-06

AUTHORS

Adeel Ahmad, Nathan D. Shemonski, Steven G. Adie, Hee-Seok Kim, Wen-Mei W. Hwu, P. Scott Carney, Stephen A. Boppart

ABSTRACT

High-resolution real-time tomography of scattering tissues is important for many areas of medicine and biology1-6. However, the compromise between transverse resolution and depth-of-field in addition to low sensitivity deep in tissue continue to impede progress towards cellular-level volumetric tomography. Computed imaging has the potential to solve these long-standing limitations. Interferometric synthetic aperture microscopy (ISAM)7-9 is a computed imaging technique enabling high-resolution volumetric tomography with spatially invariant resolution. However, its potential for clinical diagnostics remains largely untapped since full volume reconstructions required lengthy postprocessing, and the phase-stability requirements have been difficult to satisfy in vivo. Here we demonstrate how 3-D Fourier-domain resampling, in combination with high-speed optical coherence tomography (OCT), can achieve high-resolution in vivo tomography. Enhanced depth sensitivity was achieved over a depth-of-field extended in real time by more than an order of magnitude. This work lays the foundation for high-speed volumetric cellular-level tomography. More... »

PAGES

444

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nphoton.2013.71

DOI

http://dx.doi.org/10.1038/nphoton.2013.71

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029683734

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23956790


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