Self-assembled micellar nanocomplexes comprising green tea catechin derivatives and protein drugs for cancer therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-11

AUTHORS

Joo Eun Chung, Susi Tan, Shu Jun Gao, Nunnarpas Yongvongsoontorn, Soon Hee Kim, Jeong Heon Lee, Hak Soo Choi, Hirohisa Yano, Lang Zhuo, Motoichi Kurisawa, Jackie Y. Ying

ABSTRACT

When designing drug carriers, the drug-to-carrier ratio is an important consideration, because the use of high quantities of carriers can result in toxicity as a consequence of poor metabolism and elimination of the carriers. However, these issues would be of less concern if both the drug and carrier had therapeutic effects. (-)-Epigallocatechin-3-O-gallate (EGCG), a major ingredient of green tea, has been shown, for example, to possess anticancer effects, anti-HIV effects, neuroprotective effects and DNA-protective effects. Here, we show that sequential self-assembly of the EGCG derivative with anticancer proteins leads to the formation of stable micellar nanocomplexes, which have greater anticancer effects in vitro and in vivo than the free protein. The micellar nanocomplex is obtained by complexation of oligomerized EGCG with the anticancer protein Herceptin to form the core, followed by complexation of poly(ethylene glycol)-EGCG to form the shell. When injected into mice, the Herceptin-loaded micellar nanocomplex demonstrates better tumour selectivity and growth reduction, as well as longer blood half-life, than free Herceptin. More... »

PAGES

907-912

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nnano.2014.208

    DOI

    http://dx.doi.org/10.1038/nnano.2014.208

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032345546

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25282044


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