Nanopore sensors for nucleic acid analysis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-10

AUTHORS

Bala Murali Venkatesan, Rashid Bashir

ABSTRACT

Nanopore analysis is an emerging technique that involves using a voltage to drive molecules through a nanoscale pore in a membrane between two electrolytes, and monitoring how the ionic current through the nanopore changes as single molecules pass through it. This approach allows charged polymers (including single-stranded DNA, double-stranded DNA and RNA) to be analysed with subnanometre resolution and without the need for labels or amplification. Recent advances suggest that nanopore-based sensors could be competitive with other third-generation DNA sequencing technologies, and may be able to rapidly and reliably sequence the human genome for under $1,000. In this article we review the use of nanopore technology in DNA sequencing, genetics and medical diagnostics. More... »

PAGES

615

References to SciGraph publications

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  • Journal

    TITLE

    Nature Nanotechnology

    ISSUE

    10

    VOLUME

    6

    Related Patents

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  • Efficient Optical Analysis Of Polymers Using Arrays Of Nanostructures
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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nnano.2011.129

    DOI

    http://dx.doi.org/10.1038/nnano.2011.129

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021183450

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21926981


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