Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-09

AUTHORS

Georgy Mikhaylov, Ursa Mikac, Anna A. Magaeva, Volya I. Itin, Evgeniy P. Naiden, Ivan Psakhye, Liane Babes, Thomas Reinheckel, Christoph Peters, Robert Zeiser, Matthew Bogyo, Vito Turk, Sergey G. Psakhye, Boris Turk, Olga Vasiljeva

ABSTRACT

The tumour microenvironment regulates tumour progression and the spread of cancer in the body. Targeting the stromal cells that surround cancer cells could, therefore, improve the effectiveness of existing cancer treatments. Here, we show that magnetic nanoparticle clusters encapsulated inside a liposome can, under the influence of an external magnet, target both the tumour and its microenvironment. We use the outstanding T2 contrast properties (r2=573-1,286 s(-1) mM(-1)) of these ferri-liposomes, which are ∼95 nm in diameter, to non-invasively monitor drug delivery in vivo. We also visualize the targeting of the tumour microenvironment by the drug-loaded ferri-liposomes and the uptake of a model probe by cells. Furthermore, we used the ferri-liposomes to deliver a cathepsin protease inhibitor to a mammary tumour and its microenvironment in a mouse, which substantially reduced the size of the tumour compared with systemic delivery of the same drug. More... »

PAGES

594

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nnano.2011.112

DOI

http://dx.doi.org/10.1038/nnano.2011.112

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003346543

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21822252


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Delivery Systems", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liposomes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnets", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nanoparticles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Microenvironment", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Jo\u017eef Stefan Institute", 
          "id": "https://www.grid.ac/institutes/grid.11375.31", 
          "name": [
            "Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, SI-1000 Ljubljana, Slovenia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mikhaylov", 
        "givenName": "Georgy", 
        "id": "sg:person.0670241364.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670241364.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jo\u017eef Stefan Institute", 
          "id": "https://www.grid.ac/institutes/grid.11375.31", 
          "name": [
            "Department of Condensed Matter Physics, Jozef Stefan Institute, SI-1000 Ljubljana, Slovenia", 
            "Centre of Excellence EN-FIST, SI-1000 Ljubljana, Slovenia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mikac", 
        "givenName": "Ursa", 
        "id": "sg:person.014775007341.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014775007341.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Siberian Branch of the Russian Academy of Sciences", 
          "id": "https://www.grid.ac/institutes/grid.415877.8", 
          "name": [
            "Tomsk Scientific Center, Siberian Branch of Russian Academy of Sciences, Tomsk 634055, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Magaeva", 
        "givenName": "Anna A.", 
        "id": "sg:person.0771164551.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771164551.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Siberian Branch of the Russian Academy of Sciences", 
          "id": "https://www.grid.ac/institutes/grid.415877.8", 
          "name": [
            "Tomsk Scientific Center, Siberian Branch of Russian Academy of Sciences, Tomsk 634055, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Itin", 
        "givenName": "Volya I.", 
        "id": "sg:person.01332227051.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332227051.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Siberian Branch of the Russian Academy of Sciences", 
          "id": "https://www.grid.ac/institutes/grid.415877.8", 
          "name": [
            "Tomsk Scientific Center, Siberian Branch of Russian Academy of Sciences, Tomsk 634055, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Naiden", 
        "givenName": "Evgeniy P.", 
        "id": "sg:person.01037277751.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037277751.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jo\u017eef Stefan Institute", 
          "id": "https://www.grid.ac/institutes/grid.11375.31", 
          "name": [
            "Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, SI-1000 Ljubljana, Slovenia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Psakhye", 
        "givenName": "Ivan", 
        "id": "sg:person.0733557012.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733557012.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Freiburg", 
          "id": "https://www.grid.ac/institutes/grid.5963.9", 
          "name": [
            "Institut f\u00fcr Molekulare Medizin und Zellforschung, Albert-Ludwigs-Universit\u00e4t Freiburg, Freiburg 79104, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Babes", 
        "givenName": "Liane", 
        "id": "sg:person.01235144764.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235144764.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Freiburg", 
          "id": "https://www.grid.ac/institutes/grid.5963.9", 
          "name": [
            "Institut f\u00fcr Molekulare Medizin und Zellforschung, Albert-Ludwigs-Universit\u00e4t Freiburg, Freiburg 79104, Germany", 
            "BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-Universit\u00e4t Freiburg, Freiburg 79104, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reinheckel", 
        "givenName": "Thomas", 
        "id": "sg:person.01011161123.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011161123.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Freiburg", 
          "id": "https://www.grid.ac/institutes/grid.5963.9", 
          "name": [
            "Institut f\u00fcr Molekulare Medizin und Zellforschung, Albert-Ludwigs-Universit\u00e4t Freiburg, Freiburg 79104, Germany", 
            "BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-Universit\u00e4t Freiburg, Freiburg 79104, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peters", 
        "givenName": "Christoph", 
        "id": "sg:person.01351373364.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351373364.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Freiburg", 
          "id": "https://www.grid.ac/institutes/grid.7708.8", 
          "name": [
            "Department of Hematology and Oncology, University Medical Center Freiburg, Freiburg 79106, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zeiser", 
        "givenName": "Robert", 
        "id": "sg:person.01063164407.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063164407.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Department of Pathology, Microbiology and Immunology, Stanford University School of Medicine, California 94305, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bogyo", 
        "givenName": "Matthew", 
        "id": "sg:person.07456715137.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07456715137.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jo\u017eef Stefan Institute", 
          "id": "https://www.grid.ac/institutes/grid.11375.31", 
          "name": [
            "Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, SI-1000 Ljubljana, Slovenia", 
            "Center of Excellence CIPKEBIP, SI-1000 Ljubljana, Slovenia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Turk", 
        "givenName": "Vito", 
        "id": "sg:person.01322471166.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322471166.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Strength Physics and Materials Science", 
          "id": "https://www.grid.ac/institutes/grid.467103.7", 
          "name": [
            "Tomsk Scientific Center, Siberian Branch of Russian Academy of Sciences, Tomsk 634055, Russia", 
            "Institute of Strength Physics and Materials Science, Tomsk 634021, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Psakhye", 
        "givenName": "Sergey G.", 
        "id": "sg:person.01010331064.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010331064.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ljubljana", 
          "id": "https://www.grid.ac/institutes/grid.8954.0", 
          "name": [
            "Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, SI-1000 Ljubljana, Slovenia", 
            "Center of Excellence CIPKEBIP, SI-1000 Ljubljana, Slovenia", 
            "Faculty of Chemistry and Chemical Technology, University of Ljubljana, SI-1000 Ljubljana, Slovenia", 
            "Center of Excellence Nanosciences and Nanotechnology, SI-1000 Ljubljana, Slovenia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Turk", 
        "givenName": "Boris", 
        "id": "sg:person.013107422277.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013107422277.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jo\u017eef Stefan Institute", 
          "id": "https://www.grid.ac/institutes/grid.11375.31", 
          "name": [
            "Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, SI-1000 Ljubljana, Slovenia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vasiljeva", 
        "givenName": "Olga", 
        "id": "sg:person.01126306461.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126306461.45"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/adfm.200902388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000434776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/adfm.200902388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000434776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nnano.2009.333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000762723", 
          "https://doi.org/10.1038/nnano.2009.333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nnano.2009.333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000762723", 
          "https://doi.org/10.1038/nnano.2009.333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-4463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000979987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nnano.2009.202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004208062", 
          "https://doi.org/10.1038/nnano.2009.202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nnano.2009.202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004208062", 
          "https://doi.org/10.1038/nnano.2009.202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/mcp.t100003-mcp200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004993626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0606749103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005844467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1522-2586(199902)9:2<329::aid-jmri27>3.0.co;2-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006307526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/bc.2008.115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006391813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/bc.2004.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007212613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiol.2392042110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007402384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1486", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008398170", 
          "https://doi.org/10.1038/nm1486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-8853(98)00556-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012493104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiol.2411050942", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012890855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0076-6879(09)65012-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013646991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1748-0132(07)70084-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014382756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejpb.2008.09.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014446491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mri.2005.12.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023679721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1874010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024172521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrm.1910290108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027185937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029680915", 
          "https://doi.org/10.1038/nm1467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029680915", 
          "https://doi.org/10.1038/nm1467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-5521(00)00014-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029767516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(04)00117-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030138419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biochi.2007.10.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031789355"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(94)90003-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032576323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(94)90003-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032576323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0907240107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034722244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.12.3.954", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034836584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35077241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037985715", 
          "https://doi.org/10.1038/35077241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35077241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037985715", 
          "https://doi.org/10.1038/35077241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chembiol.2007.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039054935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/adma.200401904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039426729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/adma.200401904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039426729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2008.59", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040547254", 
          "https://doi.org/10.1038/onc.2008.59"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0703919104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040809227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043686693", 
          "https://doi.org/10.1038/nrc1477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043686693", 
          "https://doi.org/10.1038/nrc1477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.200604775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045155632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.200390352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045660562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(04)00111-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046267653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci38988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046612312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci38988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046612312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(94)90350-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047833690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(94)90350-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047833690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048514583", 
          "https://doi.org/10.1038/nrc1949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048514583", 
          "https://doi.org/10.1038/nrc1949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nnano.2009.231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049780763", 
          "https://doi.org/10.1038/nnano.2009.231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nnano.2009.231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049780763", 
          "https://doi.org/10.1038/nnano.2009.231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2009.217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050343581", 
          "https://doi.org/10.1038/nrclinonc.2009.217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2009.217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050343581", 
          "https://doi.org/10.1038/nrclinonc.2009.217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semcancer.2004.08.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050759655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmat1775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051729402", 
          "https://doi.org/10.1038/nmat1775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmat1775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051729402", 
          "https://doi.org/10.1038/nmat1775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-0602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051986813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cr030067f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053363526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cr030067f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053363526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja0516460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055838815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja0516460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055838815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/138161207780162962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069166146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.6.1.3669", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072298925"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-09", 
    "datePublishedReg": "2011-09-01", 
    "description": "The tumour microenvironment regulates tumour progression and the spread of cancer in the body. Targeting the stromal cells that surround cancer cells could, therefore, improve the effectiveness of existing cancer treatments. Here, we show that magnetic nanoparticle clusters encapsulated inside a liposome can, under the influence of an external magnet, target both the tumour and its microenvironment. We use the outstanding T2 contrast properties (r2=573-1,286 s(-1) mM(-1)) of these ferri-liposomes, which are \u223c95 nm in diameter, to non-invasively monitor drug delivery in vivo. We also visualize the targeting of the tumour microenvironment by the drug-loaded ferri-liposomes and the uptake of a model probe by cells. Furthermore, we used the ferri-liposomes to deliver a cathepsin protease inhibitor to a mammary tumour and its microenvironment in a mouse, which substantially reduced the size of the tumour compared with systemic delivery of the same drug.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nnano.2011.112", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3773876", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5386684", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2501621", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1037429", 
        "issn": [
          "1748-3387", 
          "1748-3395"
        ], 
        "name": "Nature Nanotechnology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment", 
    "pagination": "594", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0ff0c64ae0066597a6b50c6c988d185bd0a92bbfed6ee80a24240930f28b4c4b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21822252"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101283273"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nnano.2011.112"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003346543"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nnano.2011.112", 
      "https://app.dimensions.ai/details/publication/pub.1003346543"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nnano.2011.112"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nnano.2011.112'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nnano.2011.112'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nnano.2011.112'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nnano.2011.112'


 

This table displays all metadata directly associated to this object as RDF triples.

403 TRIPLES      21 PREDICATES      89 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nnano.2011.112 schema:about N3102a85aed694d019304ab1c3e652012
2 N39136da9bb9c4acc9d193e8f6a78b52a
3 N3b0b253b4188447aa64a004819bba710
4 N5389842810424be78c09f324d4626767
5 N548c806dee7342819ea07165bab7f385
6 N54df765b0cc64eb8bd72f6f57ee22916
7 N7f7dcec0ee574c1d8ec94bb2693392d8
8 N934d22c2792d414c9500fa7128637178
9 Nada81f803a814e3e820f73fa0ff6373b
10 Ncb50350fa12246a098fee9913ec6008d
11 Nd045d7b9728d485882f5ecee24a9204c
12 Nee6c759b8af14d57809b60f3a95160fa
13 Nf630021074964d04a8ed67fbb25361df
14 anzsrc-for:11
15 anzsrc-for:1112
16 schema:author N6ac956b91de74db98225a949ccded366
17 schema:citation sg:pub.10.1038/35077241
18 sg:pub.10.1038/nm1467
19 sg:pub.10.1038/nm1486
20 sg:pub.10.1038/nmat1775
21 sg:pub.10.1038/nnano.2009.202
22 sg:pub.10.1038/nnano.2009.231
23 sg:pub.10.1038/nnano.2009.333
24 sg:pub.10.1038/nrc1477
25 sg:pub.10.1038/nrc1949
26 sg:pub.10.1038/nrclinonc.2009.217
27 sg:pub.10.1038/onc.2008.59
28 https://doi.org/10.1002/(sici)1522-2586(199902)9:2<329::aid-jmri27>3.0.co;2-z
29 https://doi.org/10.1002/adfm.200902388
30 https://doi.org/10.1002/adma.200401904
31 https://doi.org/10.1002/anie.200390352
32 https://doi.org/10.1002/anie.200604775
33 https://doi.org/10.1002/mrm.1910290108
34 https://doi.org/10.1016/0005-2736(94)90003-5
35 https://doi.org/10.1016/0005-2736(94)90350-6
36 https://doi.org/10.1016/j.biochi.2007.10.004
37 https://doi.org/10.1016/j.chembiol.2007.03.010
38 https://doi.org/10.1016/j.ejpb.2008.09.026
39 https://doi.org/10.1016/j.mri.2005.12.033
40 https://doi.org/10.1016/j.semcancer.2004.08.001
41 https://doi.org/10.1016/s0076-6879(09)65012-6
42 https://doi.org/10.1016/s0304-8853(98)00556-3
43 https://doi.org/10.1016/s1074-5521(00)00014-4
44 https://doi.org/10.1016/s1535-6108(04)00111-4
45 https://doi.org/10.1016/s1535-6108(04)00117-5
46 https://doi.org/10.1016/s1748-0132(07)70084-1
47 https://doi.org/10.1021/cr030067f
48 https://doi.org/10.1021/ja0516460
49 https://doi.org/10.1073/pnas.0606749103
50 https://doi.org/10.1073/pnas.0703919104
51 https://doi.org/10.1073/pnas.0907240107
52 https://doi.org/10.1074/mcp.t100003-mcp200
53 https://doi.org/10.1101/gad.1874010
54 https://doi.org/10.1128/mcb.12.3.954
55 https://doi.org/10.1148/radiol.2392042110
56 https://doi.org/10.1148/radiol.2411050942
57 https://doi.org/10.1158/0008-5472.can-05-4463
58 https://doi.org/10.1158/0008-5472.can-07-0602
59 https://doi.org/10.1172/jci38988
60 https://doi.org/10.1515/bc.2004.040
61 https://doi.org/10.1515/bc.2008.115
62 https://doi.org/10.2174/138161207780162962
63 https://doi.org/10.4161/cc.6.1.3669
64 schema:datePublished 2011-09
65 schema:datePublishedReg 2011-09-01
66 schema:description The tumour microenvironment regulates tumour progression and the spread of cancer in the body. Targeting the stromal cells that surround cancer cells could, therefore, improve the effectiveness of existing cancer treatments. Here, we show that magnetic nanoparticle clusters encapsulated inside a liposome can, under the influence of an external magnet, target both the tumour and its microenvironment. We use the outstanding T2 contrast properties (r2=573-1,286 s(-1) mM(-1)) of these ferri-liposomes, which are ∼95 nm in diameter, to non-invasively monitor drug delivery in vivo. We also visualize the targeting of the tumour microenvironment by the drug-loaded ferri-liposomes and the uptake of a model probe by cells. Furthermore, we used the ferri-liposomes to deliver a cathepsin protease inhibitor to a mammary tumour and its microenvironment in a mouse, which substantially reduced the size of the tumour compared with systemic delivery of the same drug.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree false
70 schema:isPartOf N7a0ff0c2c2164ff8ac6c48f77f012c40
71 Nbd696234572541f7b931d423b6776f60
72 sg:journal.1037429
73 schema:name Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment
74 schema:pagination 594
75 schema:productId N29a3802d09834c02af60d0b5a9e0c9d6
76 N3bb7cb4f949c40aeb28780d9ccc2f6ee
77 Na7cc97635573441dacc86336616aa9ea
78 Naba91c7fe86349eabccb760fa2ed5361
79 Nca0fe3daff284b46b9081b322be9a0f2
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003346543
81 https://doi.org/10.1038/nnano.2011.112
82 schema:sdDatePublished 2019-04-11T01:48
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher N01bd9096ed2242b8a90e1ff2dd62abdc
85 schema:url https://www.nature.com/articles/nnano.2011.112
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N01bd9096ed2242b8a90e1ff2dd62abdc schema:name Springer Nature - SN SciGraph project
90 rdf:type schema:Organization
91 N12d0f8166cf94f799be34941bedaf0dd rdf:first sg:person.01037277751.02
92 rdf:rest Nbdd80975534c492aad655132dec0f65e
93 N1ea9937c39a6401993c63bd8373b2064 rdf:first sg:person.01010331064.90
94 rdf:rest N37e2f61ad8da44ee83dcc64d6f34a2e1
95 N29a3802d09834c02af60d0b5a9e0c9d6 schema:name nlm_unique_id
96 schema:value 101283273
97 rdf:type schema:PropertyValue
98 N3102a85aed694d019304ab1c3e652012 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Neoplasms
100 rdf:type schema:DefinedTerm
101 N32473ee7695d4958b414cdf15d9ae6d9 rdf:first sg:person.01011161123.78
102 rdf:rest Nba4ce03c30764437a7b34adfe8c3a6e2
103 N37e2f61ad8da44ee83dcc64d6f34a2e1 rdf:first sg:person.013107422277.47
104 rdf:rest N3a6eced6262b481284acd14de3055726
105 N39136da9bb9c4acc9d193e8f6a78b52a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Tumor Microenvironment
107 rdf:type schema:DefinedTerm
108 N3a6eced6262b481284acd14de3055726 rdf:first sg:person.01126306461.45
109 rdf:rest rdf:nil
110 N3b0b253b4188447aa64a004819bba710 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Antineoplastic Agents
112 rdf:type schema:DefinedTerm
113 N3bb7cb4f949c40aeb28780d9ccc2f6ee schema:name readcube_id
114 schema:value 0ff0c64ae0066597a6b50c6c988d185bd0a92bbfed6ee80a24240930f28b4c4b
115 rdf:type schema:PropertyValue
116 N5389842810424be78c09f324d4626767 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Mice
118 rdf:type schema:DefinedTerm
119 N548c806dee7342819ea07165bab7f385 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Cells, Cultured
121 rdf:type schema:DefinedTerm
122 N54df765b0cc64eb8bd72f6f57ee22916 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Animals
124 rdf:type schema:DefinedTerm
125 N6ac956b91de74db98225a949ccded366 rdf:first sg:person.0670241364.73
126 rdf:rest Na0e4d0f7573e414e9c07ef4885075e92
127 N6d65cfe04bb14bad96d3b9190cfd6fde rdf:first sg:person.01322471166.44
128 rdf:rest N1ea9937c39a6401993c63bd8373b2064
129 N7a0ff0c2c2164ff8ac6c48f77f012c40 schema:issueNumber 9
130 rdf:type schema:PublicationIssue
131 N7f7dcec0ee574c1d8ec94bb2693392d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Tumor Cells, Cultured
133 rdf:type schema:DefinedTerm
134 N934d22c2792d414c9500fa7128637178 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Liposomes
136 rdf:type schema:DefinedTerm
137 Na0e4d0f7573e414e9c07ef4885075e92 rdf:first sg:person.014775007341.55
138 rdf:rest Nc4a7e141b65e417faa3f4ff9477ab6a0
139 Na7cc97635573441dacc86336616aa9ea schema:name doi
140 schema:value 10.1038/nnano.2011.112
141 rdf:type schema:PropertyValue
142 Naba91c7fe86349eabccb760fa2ed5361 schema:name dimensions_id
143 schema:value pub.1003346543
144 rdf:type schema:PropertyValue
145 Nada81f803a814e3e820f73fa0ff6373b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Magnetic Resonance Imaging
147 rdf:type schema:DefinedTerm
148 Nb62c5aceb66a4a9fadd7d30a331920cd rdf:first sg:person.07456715137.22
149 rdf:rest N6d65cfe04bb14bad96d3b9190cfd6fde
150 Nb89e67ec7d564cadbbe7b78dca96f99a rdf:first sg:person.01235144764.24
151 rdf:rest N32473ee7695d4958b414cdf15d9ae6d9
152 Nba4ce03c30764437a7b34adfe8c3a6e2 rdf:first sg:person.01351373364.13
153 rdf:rest Ncbd33cb195834aa8986341db161029cf
154 Nbd696234572541f7b931d423b6776f60 schema:volumeNumber 6
155 rdf:type schema:PublicationVolume
156 Nbdd80975534c492aad655132dec0f65e rdf:first sg:person.0733557012.00
157 rdf:rest Nb89e67ec7d564cadbbe7b78dca96f99a
158 Nc4a7e141b65e417faa3f4ff9477ab6a0 rdf:first sg:person.0771164551.28
159 rdf:rest Nee921fad18fd4f32941c5b34c1bdeda9
160 Nca0fe3daff284b46b9081b322be9a0f2 schema:name pubmed_id
161 schema:value 21822252
162 rdf:type schema:PropertyValue
163 Ncb50350fa12246a098fee9913ec6008d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Nanoparticles
165 rdf:type schema:DefinedTerm
166 Ncbd33cb195834aa8986341db161029cf rdf:first sg:person.01063164407.39
167 rdf:rest Nb62c5aceb66a4a9fadd7d30a331920cd
168 Nd045d7b9728d485882f5ecee24a9204c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Magnets
170 rdf:type schema:DefinedTerm
171 Nee6c759b8af14d57809b60f3a95160fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Drug Delivery Systems
173 rdf:type schema:DefinedTerm
174 Nee921fad18fd4f32941c5b34c1bdeda9 rdf:first sg:person.01332227051.19
175 rdf:rest N12d0f8166cf94f799be34941bedaf0dd
176 Nf630021074964d04a8ed67fbb25361df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Humans
178 rdf:type schema:DefinedTerm
179 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
180 schema:name Medical and Health Sciences
181 rdf:type schema:DefinedTerm
182 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
183 schema:name Oncology and Carcinogenesis
184 rdf:type schema:DefinedTerm
185 sg:grant.2501621 http://pending.schema.org/fundedItem sg:pub.10.1038/nnano.2011.112
186 rdf:type schema:MonetaryGrant
187 sg:grant.3773876 http://pending.schema.org/fundedItem sg:pub.10.1038/nnano.2011.112
188 rdf:type schema:MonetaryGrant
189 sg:grant.5386684 http://pending.schema.org/fundedItem sg:pub.10.1038/nnano.2011.112
190 rdf:type schema:MonetaryGrant
191 sg:journal.1037429 schema:issn 1748-3387
192 1748-3395
193 schema:name Nature Nanotechnology
194 rdf:type schema:Periodical
195 sg:person.01010331064.90 schema:affiliation https://www.grid.ac/institutes/grid.467103.7
196 schema:familyName Psakhye
197 schema:givenName Sergey G.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010331064.90
199 rdf:type schema:Person
200 sg:person.01011161123.78 schema:affiliation https://www.grid.ac/institutes/grid.5963.9
201 schema:familyName Reinheckel
202 schema:givenName Thomas
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011161123.78
204 rdf:type schema:Person
205 sg:person.01037277751.02 schema:affiliation https://www.grid.ac/institutes/grid.415877.8
206 schema:familyName Naiden
207 schema:givenName Evgeniy P.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037277751.02
209 rdf:type schema:Person
210 sg:person.01063164407.39 schema:affiliation https://www.grid.ac/institutes/grid.7708.8
211 schema:familyName Zeiser
212 schema:givenName Robert
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063164407.39
214 rdf:type schema:Person
215 sg:person.01126306461.45 schema:affiliation https://www.grid.ac/institutes/grid.11375.31
216 schema:familyName Vasiljeva
217 schema:givenName Olga
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126306461.45
219 rdf:type schema:Person
220 sg:person.01235144764.24 schema:affiliation https://www.grid.ac/institutes/grid.5963.9
221 schema:familyName Babes
222 schema:givenName Liane
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235144764.24
224 rdf:type schema:Person
225 sg:person.013107422277.47 schema:affiliation https://www.grid.ac/institutes/grid.8954.0
226 schema:familyName Turk
227 schema:givenName Boris
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013107422277.47
229 rdf:type schema:Person
230 sg:person.01322471166.44 schema:affiliation https://www.grid.ac/institutes/grid.11375.31
231 schema:familyName Turk
232 schema:givenName Vito
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322471166.44
234 rdf:type schema:Person
235 sg:person.01332227051.19 schema:affiliation https://www.grid.ac/institutes/grid.415877.8
236 schema:familyName Itin
237 schema:givenName Volya I.
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332227051.19
239 rdf:type schema:Person
240 sg:person.01351373364.13 schema:affiliation https://www.grid.ac/institutes/grid.5963.9
241 schema:familyName Peters
242 schema:givenName Christoph
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351373364.13
244 rdf:type schema:Person
245 sg:person.014775007341.55 schema:affiliation https://www.grid.ac/institutes/grid.11375.31
246 schema:familyName Mikac
247 schema:givenName Ursa
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014775007341.55
249 rdf:type schema:Person
250 sg:person.0670241364.73 schema:affiliation https://www.grid.ac/institutes/grid.11375.31
251 schema:familyName Mikhaylov
252 schema:givenName Georgy
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670241364.73
254 rdf:type schema:Person
255 sg:person.0733557012.00 schema:affiliation https://www.grid.ac/institutes/grid.11375.31
256 schema:familyName Psakhye
257 schema:givenName Ivan
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733557012.00
259 rdf:type schema:Person
260 sg:person.07456715137.22 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
261 schema:familyName Bogyo
262 schema:givenName Matthew
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07456715137.22
264 rdf:type schema:Person
265 sg:person.0771164551.28 schema:affiliation https://www.grid.ac/institutes/grid.415877.8
266 schema:familyName Magaeva
267 schema:givenName Anna A.
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771164551.28
269 rdf:type schema:Person
270 sg:pub.10.1038/35077241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037985715
271 https://doi.org/10.1038/35077241
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/nm1467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029680915
274 https://doi.org/10.1038/nm1467
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/nm1486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008398170
277 https://doi.org/10.1038/nm1486
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/nmat1775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051729402
280 https://doi.org/10.1038/nmat1775
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/nnano.2009.202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004208062
283 https://doi.org/10.1038/nnano.2009.202
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/nnano.2009.231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049780763
286 https://doi.org/10.1038/nnano.2009.231
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/nnano.2009.333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000762723
289 https://doi.org/10.1038/nnano.2009.333
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/nrc1477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043686693
292 https://doi.org/10.1038/nrc1477
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/nrc1949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048514583
295 https://doi.org/10.1038/nrc1949
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/nrclinonc.2009.217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050343581
298 https://doi.org/10.1038/nrclinonc.2009.217
299 rdf:type schema:CreativeWork
300 sg:pub.10.1038/onc.2008.59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040547254
301 https://doi.org/10.1038/onc.2008.59
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1002/(sici)1522-2586(199902)9:2<329::aid-jmri27>3.0.co;2-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1006307526
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1002/adfm.200902388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000434776
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1002/adma.200401904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039426729
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1002/anie.200390352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045660562
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1002/anie.200604775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045155632
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1002/mrm.1910290108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027185937
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/0005-2736(94)90003-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032576323
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/0005-2736(94)90350-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047833690
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.biochi.2007.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031789355
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.chembiol.2007.03.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039054935
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/j.ejpb.2008.09.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014446491
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/j.mri.2005.12.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023679721
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/j.semcancer.2004.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050759655
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/s0076-6879(09)65012-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013646991
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/s0304-8853(98)00556-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012493104
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/s1074-5521(00)00014-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029767516
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/s1535-6108(04)00111-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046267653
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/s1535-6108(04)00117-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030138419
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/s1748-0132(07)70084-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014382756
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1021/cr030067f schema:sameAs https://app.dimensions.ai/details/publication/pub.1053363526
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1021/ja0516460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055838815
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1073/pnas.0606749103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005844467
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1073/pnas.0703919104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040809227
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1073/pnas.0907240107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034722244
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1074/mcp.t100003-mcp200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004993626
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1101/gad.1874010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024172521
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1128/mcb.12.3.954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034836584
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1148/radiol.2392042110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007402384
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1148/radiol.2411050942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012890855
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1158/0008-5472.can-05-4463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000979987
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1158/0008-5472.can-07-0602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051986813
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1172/jci38988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046612312
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1515/bc.2004.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007212613
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1515/bc.2008.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006391813
370 rdf:type schema:CreativeWork
371 https://doi.org/10.2174/138161207780162962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069166146
372 rdf:type schema:CreativeWork
373 https://doi.org/10.4161/cc.6.1.3669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298925
374 rdf:type schema:CreativeWork
375 https://www.grid.ac/institutes/grid.11375.31 schema:alternateName Jožef Stefan Institute
376 schema:name Center of Excellence CIPKEBIP, SI-1000 Ljubljana, Slovenia
377 Centre of Excellence EN-FIST, SI-1000 Ljubljana, Slovenia
378 Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, SI-1000 Ljubljana, Slovenia
379 Department of Condensed Matter Physics, Jozef Stefan Institute, SI-1000 Ljubljana, Slovenia
380 rdf:type schema:Organization
381 https://www.grid.ac/institutes/grid.168010.e schema:alternateName Stanford University
382 schema:name Department of Pathology, Microbiology and Immunology, Stanford University School of Medicine, California 94305, USA
383 rdf:type schema:Organization
384 https://www.grid.ac/institutes/grid.415877.8 schema:alternateName Siberian Branch of the Russian Academy of Sciences
385 schema:name Tomsk Scientific Center, Siberian Branch of Russian Academy of Sciences, Tomsk 634055, Russia
386 rdf:type schema:Organization
387 https://www.grid.ac/institutes/grid.467103.7 schema:alternateName Institute of Strength Physics and Materials Science
388 schema:name Institute of Strength Physics and Materials Science, Tomsk 634021, Russia
389 Tomsk Scientific Center, Siberian Branch of Russian Academy of Sciences, Tomsk 634055, Russia
390 rdf:type schema:Organization
391 https://www.grid.ac/institutes/grid.5963.9 schema:alternateName University of Freiburg
392 schema:name BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-Universität Freiburg, Freiburg 79104, Germany
393 Institut für Molekulare Medizin und Zellforschung, Albert-Ludwigs-Universität Freiburg, Freiburg 79104, Germany
394 rdf:type schema:Organization
395 https://www.grid.ac/institutes/grid.7708.8 schema:alternateName University Medical Center Freiburg
396 schema:name Department of Hematology and Oncology, University Medical Center Freiburg, Freiburg 79106, Germany
397 rdf:type schema:Organization
398 https://www.grid.ac/institutes/grid.8954.0 schema:alternateName University of Ljubljana
399 schema:name Center of Excellence CIPKEBIP, SI-1000 Ljubljana, Slovenia
400 Center of Excellence Nanosciences and Nanotechnology, SI-1000 Ljubljana, Slovenia
401 Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, SI-1000 Ljubljana, Slovenia
402 Faculty of Chemistry and Chemical Technology, University of Ljubljana, SI-1000 Ljubljana, Slovenia
403 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...