Three-dimensional tissue culture based on magnetic cell levitation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-04

AUTHORS

Glauco R. Souza, Jennifer R. Molina, Robert M. Raphael, Michael G. Ozawa, Daniel J. Stark, Carly S. Levin, Lawrence F. Bronk, Jeyarama S. Ananta, Jami Mandelin, Maria-Magdalena Georgescu, James A. Bankson, Juri G. Gelovani, T. C. Killian, Wadih Arap, Renata Pasqualini

ABSTRACT

Cell culture is an essential tool in drug discovery, tissue engineering and stem cell research. Conventional tissue culture produces two-dimensional cell growth with gene expression, signalling and morphology that can be different from those found in vivo, and this compromises its clinical relevance. Here, we report a three-dimensional tissue culture based on magnetic levitation of cells in the presence of a hydrogel consisting of gold, magnetic iron oxide nanoparticles and filamentous bacteriophage. By spatially controlling the magnetic field, the geometry of the cell mass can be manipulated, and multicellular clustering of different cell types in co-culture can be achieved. Magnetically levitated human glioblastoma cells showed similar protein expression profiles to those observed in human tumour xenografts. Taken together, these results indicate that levitated three-dimensional culture with magnetized phage-based hydrogels more closely recapitulates in vivo protein expression and may be more feasible for long-term multicellular studies. More... »

PAGES

291

References to SciGraph publications

  • 2008-10. Mechanics of mesenchymal contribution to clefting force in branching morphogenesis in BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
  • 2000-09. Mechanical control of cyclic AMP signalling and gene transcription through integrins in NATURE CELL BIOLOGY
  • 1997-12. Mitogens as motogens in JOURNAL OF NEURO-ONCOLOGY
  • 2003-08. Cell culture: Biology's new dimension in NATURE
  • 2007-10. The third dimension bridges the gap between cell culture and live tissue in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2004-04. Designing materials for biology and medicine in NATURE
  • 2006-03. Capturing complex 3D tissue physiology in vitro in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2008-03. Remote control of cellular behaviour with magnetic nanoparticles in NATURE NANOTECHNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nnano.2010.23

    DOI

    http://dx.doi.org/10.1038/nnano.2010.23

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044843350

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20228788


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