Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-01-25

AUTHORS

Oliver T. Bruns, Harald Ittrich, Kersten Peldschus, Michael G. Kaul, Ulrich I. Tromsdorf, Joachim Lauterwasser, Marija S. Nikolic, Birgit Mollwitz, Martin Merkel, Nadja C. Bigall, Sameer Sapra, Rudolph Reimer, Heinz Hohenberg, Horst Weller, Alexander Eychmüller, Gerhard Adam, Ulrike Beisiegel, Joerg Heeren

ABSTRACT

Semiconductor quantum dots and superparamagnetic iron oxide nanocrystals have physical properties that are well suited for biomedical imaging. Previously, we have shown that iron oxide nanocrystals embedded within the lipid core of micelles show optimized characteristics for quantitative imaging. Here, we embed quantum dots and superparamagnetic iron oxide nanocrystals in the core of lipoproteins—micelles that transport lipids and other hydrophobic substances in the blood—and show that it is possible to image and quantify the kinetics of lipoprotein metabolism in vivo using fluorescence and dynamic magnetic resonance imaging. The lipoproteins were taken up by liver cells in wild-type mice and displayed defective clearance in knock-out mice lacking a lipoprotein receptor or its ligand, indicating that the nanocrystals did not influence the specificity of the metabolic process. Using this strategy it is possible to study the clearance of lipoproteins in metabolic disorders and to improve the contrast in clinical imaging. More... »

PAGES

193-201

Journal

TITLE

Nature Nanotechnology

ISSUE

3

VOLUME

4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nnano.2008.405

DOI

http://dx.doi.org/10.1038/nnano.2008.405

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027775537

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19265850


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