Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-03

AUTHORS

Ennio Tasciotti, Xuewu Liu, Rohan Bhavane, Kevin Plant, Ashley D. Leonard, B. Katherine Price, Mark Ming-Cheng Cheng, Paolo Decuzzi, James M. Tour, Fredika Robertson, Mauro Ferrari

ABSTRACT

Many nanosized particulate systems are being developed as intravascular carriers to increase the levels of therapeutic agents delivered to targets, with the fewest side effects. The surface of these carriers is often functionalized with biological recognition molecules for specific, targeted delivery. However, there are a series of biological barriers in the body that prevent these carriers from localizing at their targets at sufficiently high therapeutic concentrations. Here we show a multistage delivery system that can carry, release over time and deliver two types of nanoparticles into primary endothelial cells. The multistage delivery system is based on biodegradable and biocompatible mesoporous silicon particles that have well-controlled shapes, sizes and pores. The use of this system is envisioned to open new avenues for avoiding biological barriers and delivering more than one therapeutic agent to the target at a time, in a time-controlled fashion. More... »

PAGES

151-157

Journal

TITLE

Nature Nanotechnology

ISSUE

3

VOLUME

3

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nnano.2008.34

    DOI

    http://dx.doi.org/10.1038/nnano.2008.34

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007459374

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18654487


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nnano.2008.34'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nnano.2008.34'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nnano.2008.34'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nnano.2008.34'


     

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