Local self-renewal can sustain CNS microglia maintenance and function throughout adult life View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-12

AUTHORS

Bahareh Ajami, Jami L Bennett, Charles Krieger, Wolfram Tetzlaff, Fabio M V Rossi

ABSTRACT

Microgliosis is a common response to multiple types of damage in the CNS. However, the origin of the cells involved in this process is still controversial and the relative importance of local expansion versus recruitment of microglia progenitors from the bloodstream is unclear. Here, we investigated the origin of microglia using chimeric animals obtained by parabiosis. We found no evidence of microglia progenitor recruitment from the circulation in denervation or CNS neurodegenerative disease, suggesting that maintenance and local expansion of microglia are solely dependent on the self-renewal of CNS resident cells in these models. More... »

PAGES

1538-1543

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn2014

DOI

http://dx.doi.org/10.1038/nn2014

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045731969

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18026097


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

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N-Triples is a line-based linked data format ideal for batch operations.

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Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nn2014'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nn2014'


 

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