Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-12

AUTHORS

Matthew E Klein, Daniel T Lioy, Lin Ma, Soren Impey, Gail Mandel, Richard H Goodman

ABSTRACT

Both increases and decreases in methyl CpG-binding protein 2 (MeCP2) levels cause neurodevelopmental defects. We found that MeCP2 translation is regulated by microRNA 132 (miR132). Block of miR132-mediated repression increased MeCP2 and brain-derived neurotrophic factor (BDNF) levels in cultured rat neurons and the loss of MeCP2 reduced BDNF and miR132 levels in vivo. This feedback loop may provide a mechanism for homeostatic control of MeCP2 expression. More... »

PAGES

1513-1514

Journal

TITLE

Nature Neuroscience

ISSUE

12

VOLUME

10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn2010

DOI

http://dx.doi.org/10.1038/nn2010

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049880443

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17994015


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