Microglia: active sensor and versatile effector cells in the normal and pathologic brain View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-11

AUTHORS

Uwe-Karsten Hanisch, Helmut Kettenmann

ABSTRACT

Microglial cells constitute the resident macrophage population of the CNS. Recent in vivo studies have shown that microglia carry out active tissue scanning, which challenges the traditional notion of 'resting' microglia in the normal brain. Transformation of microglia to reactive states in response to pathology has been known for decades as microglial activation, but seems to be more diverse and dynamic than ever anticipated--in both transcriptional and nontranscriptional features and functional consequences. This may help to explain why engagement of microglia can be either neuroprotective or neurotoxic, resulting in containment or aggravation of disease progression. Moreover, little is known about the heterogeneity of microglial responses in different pathologic contexts that results from regional adaptations or from the progression of a disease. In this review, we focus on several key observations that illustrate the multi-faceted activities of microglia in the normal and pathologic brain. More... »

PAGES

1387-1394

References to SciGraph publications

  • 2006-09. Modulation of microglial pro-inflammatory and neurotoxic activity for the treatment of Parkinson’s disease in THE AAPS JOURNAL
  • 2007-04. Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease in NATURE MEDICINE
  • 2005-06. ATP mediates rapid microglial response to local brain injury in vivo in NATURE NEUROSCIENCE
  • 2005-12. Monocyte and macrophage heterogeneity in NATURE REVIEWS IMMUNOLOGY
  • 2005-12. Resolution of inflammation: the beginning programs the end in NATURE IMMUNOLOGY
  • 2006. Role of microglia in inflammation-mediated degeneration of dopaminergic neurons: neuroprotective effect of Interleukin 10 in PARKINSON’S DISEASE AND RELATED DISORDERS
  • 2006-12. The P2Y12 receptor regulates microglial activation by extracellular nucleotides in NATURE NEUROSCIENCE
  • 2007-01. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms in NATURE REVIEWS NEUROSCIENCE
  • 2004-12. Microglia in METABOLIC BRAIN DISEASE
  • 2006-02. Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood in NATURE NEUROSCIENCE
  • 2006-07. Control of microglial neurotoxicity by the fractalkine receptor in NATURE NEUROSCIENCE
  • 2005-02. Experimental autoimmune encephalomyelitis repressed by microglial paralysis in NATURE MEDICINE
  • 2003-09. Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS in NATURE REVIEWS NEUROSCIENCE
  • 2006-08. Purinergic signaling and microglia in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2006-03. Particularities of the vasculature can promote the organ specificity of autoimmune attack in NATURE IMMUNOLOGY
  • 2007-05. Innate immunity of the newborn: basic mechanisms and clinical correlates in NATURE REVIEWS IMMUNOLOGY
  • 2007-03. Cooperation of Toll-like receptor signals in innate immune defence in NATURE REVIEWS IMMUNOLOGY
  • 2000-11. Distinct Physiologic Properties of Microglia and Blood-Borne Cells in Rat Brain Slices After Permanent Middle Cerebral Artery Occlusion in JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nn1997

    DOI

    http://dx.doi.org/10.1038/nn1997

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006831469

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17965659


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain Diseases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Microglia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Biological", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of G\u00f6ttingen", 
              "id": "https://www.grid.ac/institutes/grid.7450.6", 
              "name": [
                "Institute of Neuropathology, University of G\u00f6ttingen, Robert-Koch-Stra\u00dfe 40, D-37075 G\u00f6ttingen, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hanisch", 
            "givenName": "Uwe-Karsten", 
            "id": "sg:person.0713335233.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713335233.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Max Delbr\u00fcck Center for Molecular Medicine", 
              "id": "https://www.grid.ac/institutes/grid.419491.0", 
              "name": [
                "Cellular Neuroscience, Max Delbr\u00fcck Center for Molecular Medicine, Robert-R\u00f6ssle-Stra\u00dfe 10, D-13092 Berlin, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kettenmann", 
            "givenName": "Helmut", 
            "id": "sg:person.01321401763.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321401763.44"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1097/00004647-200011000-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000665398", 
              "https://doi.org/10.1097/00004647-200011000-00003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-200011000-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000665398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00004647-200011000-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000665398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.177.4.2051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002279127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tins.2005.12.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002770331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1460-9568.2003.02663.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004804463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn2038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004977965", 
              "https://doi.org/10.1038/nrn2038"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn2038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004977965", 
              "https://doi.org/10.1038/nrn2038"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1555", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005024045", 
              "https://doi.org/10.1038/nm1555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2007.02.055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005441422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1306", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005972726", 
              "https://doi.org/10.1038/ni1306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1306", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005972726", 
              "https://doi.org/10.1038/ni1306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.4371-06.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006115366"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1460-9568.2002.02287.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006233991"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.04-1517fje", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007570139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1808-05.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008184119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0896-6273(04)00069-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008621909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1189/jlb.0504272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008662355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1629", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008854607", 
              "https://doi.org/10.1038/nn1629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1629", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008854607", 
              "https://doi.org/10.1038/nn1629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nbd.2003.11.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008876601"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.173.6.3916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008927643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.brainresrev.2006.11.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009705897"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1276", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009927742", 
              "https://doi.org/10.1038/ni1276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1276", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009927742", 
              "https://doi.org/10.1038/ni1276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011537546", 
              "https://doi.org/10.1038/nri2038"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)00023-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012421191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012994687", 
              "https://doi.org/10.1038/nri1733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1733", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012994687", 
              "https://doi.org/10.1038/nri1733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.20191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015282586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awl206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015927577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2275-06.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016058842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.brainresrev.2007.03.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016568416"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mcn.2007.04.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016603934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-0365", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019019177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awl263", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019270489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0166-2236(96)10049-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019601232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn1195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019705995", 
              "https://doi.org/10.1038/nrn1195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn1195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019705995", 
              "https://doi.org/10.1038/nrn1195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2004.02954.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020344444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20051529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020464518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20051529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020464518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021332650", 
              "https://doi.org/10.1038/nn1715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021332650", 
              "https://doi.org/10.1038/nn1715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci26836", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022644985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0169-328x(99)00016-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023105610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tins.2006.07.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023597634"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1248/bpb.25.945", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025799441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1521-4141(200107)31:7<2104::aid-immu2104>3.0.co;2-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025864022"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.20459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026085963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028961315", 
              "https://doi.org/10.1038/nm1177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028961315", 
              "https://doi.org/10.1038/nm1177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.94.8.4080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029885226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.10637", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030018242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.172.4.1025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030148652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.e06-10-0975", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031104672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/revneuro.2002.13.3.221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031122800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.20562", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031511080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.20562", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031511080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2451-04.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031774215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.5321-06.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033008560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1076/jhin.11.4.325.8531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033242913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-211-45295-0_56", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034247583", 
              "https://doi.org/10.1007/978-3-211-45295-0_56"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1088417", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034380276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.175.1.342", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034427592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(92)90500-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034836912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(92)90500-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034836912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.0953-816x.2001.01793.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035209840"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2249.2005.02934.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035252138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.20535", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035461514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/exnr.2000.7618", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036815072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0165-5728(00)00239-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037802785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1208/aapsj080369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038414581", 
              "https://doi.org/10.1208/aapsj080369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.20482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038504595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.20482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038504595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.brainresrev.2004.12.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039684183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.2234031100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039848645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.20468", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040216532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mcn.2005.10.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040513941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mcn.2005.10.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040513941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1805", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040834299", 
              "https://doi.org/10.1038/nn1805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1805", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040834299", 
              "https://doi.org/10.1038/nn1805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0165-0173(99)00024-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040838990"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.05-5106com", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041184828"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2007.01.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042207199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2531-06.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042530449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0969-9961(02)00008-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043370342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0969-9961(02)00008-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043370342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.20462", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044029315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.jcbfm.9600362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045734412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.jcbfm.9600362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045734412"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1254/jphs.94.203", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045838866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1472", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046138818", 
              "https://doi.org/10.1038/nn1472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1472", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046138818", 
              "https://doi.org/10.1038/nn1472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1472", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046138818", 
              "https://doi.org/10.1038/nn1472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mcn.2005.03.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046367844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mcn.2005.03.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046367844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.1198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046761722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/b:mebr.0000043984.73063.d8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046919957", 
              "https://doi.org/10.1023/b:mebr.0000043984.73063.d8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.20659", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047386904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.20659", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047386904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1110647", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047502402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.10057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047994851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.5360-06.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048131984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nbd.2004.09.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049109059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.4540-04.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049775522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.jcbfm.9600495", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050300590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.jcbfm.9600495", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050300590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051451357", 
              "https://doi.org/10.1038/nri2075"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00424-006-0064-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051500154", 
              "https://doi.org/10.1007/s00424-006-0064-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00424-006-0064-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051500154", 
              "https://doi.org/10.1007/s00424-006-0064-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.it.2006.11.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051587674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.20332", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052285355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.20332", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052285355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.10306", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052859344"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awf015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053412776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.jnen.0000178445.33972.a9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060330607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1092864", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062449226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.290.5497.1768", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062572307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/135245850000600108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063988606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/135245850000600108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063988606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/135245850000600108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063988606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.167.9.5004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074944291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.172.11.7144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1076842257"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.16-08-02508.1996", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082954712"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2007-11", 
        "datePublishedReg": "2007-11-01", 
        "description": "Microglial cells constitute the resident macrophage population of the CNS. Recent in vivo studies have shown that microglia carry out active tissue scanning, which challenges the traditional notion of 'resting' microglia in the normal brain. Transformation of microglia to reactive states in response to pathology has been known for decades as microglial activation, but seems to be more diverse and dynamic than ever anticipated--in both transcriptional and nontranscriptional features and functional consequences. This may help to explain why engagement of microglia can be either neuroprotective or neurotoxic, resulting in containment or aggravation of disease progression. Moreover, little is known about the heterogeneity of microglial responses in different pathologic contexts that results from regional adaptations or from the progression of a disease. In this review, we focus on several key observations that illustrate the multi-faceted activities of microglia in the normal and pathologic brain.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nn1997", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1118362", 
            "issn": [
              "1097-6256", 
              "1546-1726"
            ], 
            "name": "Nature Neuroscience", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "11", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "name": "Microglia: active sensor and versatile effector cells in the normal and pathologic brain", 
        "pagination": "1387-1394", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "208a920cf9d4175725a4df57d0466505ea86db295f3e8130d886e276077f12fe"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "17965659"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9809671"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nn1997"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1006831469"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nn1997", 
          "https://app.dimensions.ai/details/publication/pub.1006831469"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T23:11", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000421.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/nn1997"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nn1997'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nn1997'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nn1997'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nn1997'


     

    This table displays all metadata directly associated to this object as RDF triples.

    418 TRIPLES      21 PREDICATES      134 URIs      27 LITERALS      15 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nn1997 schema:about N2c5d14ea29ac434697e080c5d810c2df
    2 N32012be351b544af98482eed19c86b69
    3 N719996c216ac40f883eff7fd4667dee3
    4 N751220b086f8488c9f87ff7788b19fce
    5 N834a85d8b0764e8c922c16ad767d375e
    6 Nfd572079e8974011b56edfe4dab60e04
    7 anzsrc-for:11
    8 anzsrc-for:1109
    9 schema:author Nc4f9b33f6daa4b879f4fcd7ebc1aa384
    10 schema:citation sg:pub.10.1007/978-3-211-45295-0_56
    11 sg:pub.10.1007/s00424-006-0064-7
    12 sg:pub.10.1023/b:mebr.0000043984.73063.d8
    13 sg:pub.10.1038/ni1276
    14 sg:pub.10.1038/ni1306
    15 sg:pub.10.1038/nm1177
    16 sg:pub.10.1038/nm1555
    17 sg:pub.10.1038/nn1472
    18 sg:pub.10.1038/nn1629
    19 sg:pub.10.1038/nn1715
    20 sg:pub.10.1038/nn1805
    21 sg:pub.10.1038/nri1733
    22 sg:pub.10.1038/nri2038
    23 sg:pub.10.1038/nri2075
    24 sg:pub.10.1038/nrn1195
    25 sg:pub.10.1038/nrn2038
    26 sg:pub.10.1097/00004647-200011000-00003
    27 sg:pub.10.1208/aapsj080369
    28 https://doi.org/10.1002/1521-4141(200107)31:7<2104::aid-immu2104>3.0.co;2-3
    29 https://doi.org/10.1002/glia.10057
    30 https://doi.org/10.1002/glia.10306
    31 https://doi.org/10.1002/glia.20191
    32 https://doi.org/10.1002/glia.20332
    33 https://doi.org/10.1002/glia.20459
    34 https://doi.org/10.1002/glia.20462
    35 https://doi.org/10.1002/glia.20468
    36 https://doi.org/10.1002/glia.20535
    37 https://doi.org/10.1002/jnr.10637
    38 https://doi.org/10.1002/jnr.1198
    39 https://doi.org/10.1002/jnr.20482
    40 https://doi.org/10.1002/jnr.20562
    41 https://doi.org/10.1002/jnr.20659
    42 https://doi.org/10.1006/exnr.2000.7618
    43 https://doi.org/10.1016/0166-2236(96)10049-7
    44 https://doi.org/10.1016/0306-4522(92)90500-2
    45 https://doi.org/10.1016/j.brainresrev.2004.12.009
    46 https://doi.org/10.1016/j.brainresrev.2006.11.002
    47 https://doi.org/10.1016/j.brainresrev.2007.03.012
    48 https://doi.org/10.1016/j.febslet.2007.01.009
    49 https://doi.org/10.1016/j.it.2006.11.004
    50 https://doi.org/10.1016/j.mcn.2005.03.005
    51 https://doi.org/10.1016/j.mcn.2005.10.006
    52 https://doi.org/10.1016/j.mcn.2007.04.009
    53 https://doi.org/10.1016/j.nbd.2003.11.007
    54 https://doi.org/10.1016/j.nbd.2004.09.019
    55 https://doi.org/10.1016/j.neuroscience.2007.02.055
    56 https://doi.org/10.1016/j.tins.2005.12.005
    57 https://doi.org/10.1016/j.tins.2006.07.001
    58 https://doi.org/10.1016/s0165-0173(99)00024-7
    59 https://doi.org/10.1016/s0165-5728(00)00239-3
    60 https://doi.org/10.1016/s0169-328x(99)00016-9
    61 https://doi.org/10.1016/s0896-6273(04)00069-8
    62 https://doi.org/10.1016/s0969-9961(02)00008-6
    63 https://doi.org/10.1016/s1074-7613(00)00023-6
    64 https://doi.org/10.1038/sj.jcbfm.9600362
    65 https://doi.org/10.1038/sj.jcbfm.9600495
    66 https://doi.org/10.1046/j.0953-816x.2001.01793.x
    67 https://doi.org/10.1046/j.1460-9568.2002.02287.x
    68 https://doi.org/10.1046/j.1460-9568.2003.02663.x
    69 https://doi.org/10.1073/pnas.2234031100
    70 https://doi.org/10.1073/pnas.94.8.4080
    71 https://doi.org/10.1076/jhin.11.4.325.8531
    72 https://doi.org/10.1084/jem.172.4.1025
    73 https://doi.org/10.1084/jem.20051529
    74 https://doi.org/10.1091/mbc.e06-10-0975
    75 https://doi.org/10.1093/brain/awf015
    76 https://doi.org/10.1093/brain/awl206
    77 https://doi.org/10.1093/brain/awl263
    78 https://doi.org/10.1096/fj.04-1517fje
    79 https://doi.org/10.1096/fj.05-5106com
    80 https://doi.org/10.1097/00004647-200011000-00003
    81 https://doi.org/10.1097/01.jnen.0000178445.33972.a9
    82 https://doi.org/10.1111/j.1365-2249.2005.02934.x
    83 https://doi.org/10.1111/j.1471-4159.2004.02954.x
    84 https://doi.org/10.1126/science.1088417
    85 https://doi.org/10.1126/science.1092864
    86 https://doi.org/10.1126/science.1110647
    87 https://doi.org/10.1126/science.290.5497.1768
    88 https://doi.org/10.1158/0008-5472.can-06-0365
    89 https://doi.org/10.1172/jci26836
    90 https://doi.org/10.1177/135245850000600108
    91 https://doi.org/10.1189/jlb.0504272
    92 https://doi.org/10.1248/bpb.25.945
    93 https://doi.org/10.1254/jphs.94.203
    94 https://doi.org/10.1515/revneuro.2002.13.3.221
    95 https://doi.org/10.1523/jneurosci.16-08-02508.1996
    96 https://doi.org/10.1523/jneurosci.1808-05.2005
    97 https://doi.org/10.1523/jneurosci.2275-06.2006
    98 https://doi.org/10.1523/jneurosci.2451-04.2004
    99 https://doi.org/10.1523/jneurosci.2531-06.2006
    100 https://doi.org/10.1523/jneurosci.4371-06.2007
    101 https://doi.org/10.1523/jneurosci.4540-04.2005
    102 https://doi.org/10.1523/jneurosci.5321-06.2007
    103 https://doi.org/10.1523/jneurosci.5360-06.2007
    104 https://doi.org/10.4049/jimmunol.167.9.5004
    105 https://doi.org/10.4049/jimmunol.172.11.7144
    106 https://doi.org/10.4049/jimmunol.173.6.3916
    107 https://doi.org/10.4049/jimmunol.175.1.342
    108 https://doi.org/10.4049/jimmunol.177.4.2051
    109 schema:datePublished 2007-11
    110 schema:datePublishedReg 2007-11-01
    111 schema:description Microglial cells constitute the resident macrophage population of the CNS. Recent in vivo studies have shown that microglia carry out active tissue scanning, which challenges the traditional notion of 'resting' microglia in the normal brain. Transformation of microglia to reactive states in response to pathology has been known for decades as microglial activation, but seems to be more diverse and dynamic than ever anticipated--in both transcriptional and nontranscriptional features and functional consequences. This may help to explain why engagement of microglia can be either neuroprotective or neurotoxic, resulting in containment or aggravation of disease progression. Moreover, little is known about the heterogeneity of microglial responses in different pathologic contexts that results from regional adaptations or from the progression of a disease. In this review, we focus on several key observations that illustrate the multi-faceted activities of microglia in the normal and pathologic brain.
    112 schema:genre research_article
    113 schema:inLanguage en
    114 schema:isAccessibleForFree false
    115 schema:isPartOf N2fa122b4630240618c3eaeb51a339733
    116 N68e37fbdc47249ab88e25f2397cda8e5
    117 sg:journal.1118362
    118 schema:name Microglia: active sensor and versatile effector cells in the normal and pathologic brain
    119 schema:pagination 1387-1394
    120 schema:productId N2edde5bc107a4941b5ab6f22bb43a92c
    121 N845c37faeaed4ad68ae5b2d72dec3503
    122 Nc85015f80d324885b8be2f8fb5245b8c
    123 Nd0eee97a0cf4411c9b6579c2b66823c9
    124 Ne8d018369e834ab09b4324a24e15e973
    125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006831469
    126 https://doi.org/10.1038/nn1997
    127 schema:sdDatePublished 2019-04-10T23:11
    128 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    129 schema:sdPublisher N410dd13ee18f4f8781ab6e271d65b660
    130 schema:url http://www.nature.com/articles/nn1997
    131 sgo:license sg:explorer/license/
    132 sgo:sdDataset articles
    133 rdf:type schema:ScholarlyArticle
    134 N2c5d14ea29ac434697e080c5d810c2df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Brain
    136 rdf:type schema:DefinedTerm
    137 N2edde5bc107a4941b5ab6f22bb43a92c schema:name doi
    138 schema:value 10.1038/nn1997
    139 rdf:type schema:PropertyValue
    140 N2fa122b4630240618c3eaeb51a339733 schema:volumeNumber 10
    141 rdf:type schema:PublicationVolume
    142 N32012be351b544af98482eed19c86b69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Microglia
    144 rdf:type schema:DefinedTerm
    145 N39bc297227f14469a06b7a0cae001971 rdf:first sg:person.01321401763.44
    146 rdf:rest rdf:nil
    147 N410dd13ee18f4f8781ab6e271d65b660 schema:name Springer Nature - SN SciGraph project
    148 rdf:type schema:Organization
    149 N68e37fbdc47249ab88e25f2397cda8e5 schema:issueNumber 11
    150 rdf:type schema:PublicationIssue
    151 N719996c216ac40f883eff7fd4667dee3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Humans
    153 rdf:type schema:DefinedTerm
    154 N751220b086f8488c9f87ff7788b19fce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Brain Diseases
    156 rdf:type schema:DefinedTerm
    157 N834a85d8b0764e8c922c16ad767d375e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Animals
    159 rdf:type schema:DefinedTerm
    160 N845c37faeaed4ad68ae5b2d72dec3503 schema:name nlm_unique_id
    161 schema:value 9809671
    162 rdf:type schema:PropertyValue
    163 Nc4f9b33f6daa4b879f4fcd7ebc1aa384 rdf:first sg:person.0713335233.38
    164 rdf:rest N39bc297227f14469a06b7a0cae001971
    165 Nc85015f80d324885b8be2f8fb5245b8c schema:name dimensions_id
    166 schema:value pub.1006831469
    167 rdf:type schema:PropertyValue
    168 Nd0eee97a0cf4411c9b6579c2b66823c9 schema:name readcube_id
    169 schema:value 208a920cf9d4175725a4df57d0466505ea86db295f3e8130d886e276077f12fe
    170 rdf:type schema:PropertyValue
    171 Ne8d018369e834ab09b4324a24e15e973 schema:name pubmed_id
    172 schema:value 17965659
    173 rdf:type schema:PropertyValue
    174 Nfd572079e8974011b56edfe4dab60e04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Models, Biological
    176 rdf:type schema:DefinedTerm
    177 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    178 schema:name Medical and Health Sciences
    179 rdf:type schema:DefinedTerm
    180 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    181 schema:name Neurosciences
    182 rdf:type schema:DefinedTerm
    183 sg:journal.1118362 schema:issn 1097-6256
    184 1546-1726
    185 schema:name Nature Neuroscience
    186 rdf:type schema:Periodical
    187 sg:person.01321401763.44 schema:affiliation https://www.grid.ac/institutes/grid.419491.0
    188 schema:familyName Kettenmann
    189 schema:givenName Helmut
    190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321401763.44
    191 rdf:type schema:Person
    192 sg:person.0713335233.38 schema:affiliation https://www.grid.ac/institutes/grid.7450.6
    193 schema:familyName Hanisch
    194 schema:givenName Uwe-Karsten
    195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713335233.38
    196 rdf:type schema:Person
    197 sg:pub.10.1007/978-3-211-45295-0_56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034247583
    198 https://doi.org/10.1007/978-3-211-45295-0_56
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1007/s00424-006-0064-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051500154
    201 https://doi.org/10.1007/s00424-006-0064-7
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1023/b:mebr.0000043984.73063.d8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046919957
    204 https://doi.org/10.1023/b:mebr.0000043984.73063.d8
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1038/ni1276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009927742
    207 https://doi.org/10.1038/ni1276
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/ni1306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005972726
    210 https://doi.org/10.1038/ni1306
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1038/nm1177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028961315
    213 https://doi.org/10.1038/nm1177
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/nm1555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005024045
    216 https://doi.org/10.1038/nm1555
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/nn1472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046138818
    219 https://doi.org/10.1038/nn1472
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/nn1629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008854607
    222 https://doi.org/10.1038/nn1629
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/nn1715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021332650
    225 https://doi.org/10.1038/nn1715
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/nn1805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040834299
    228 https://doi.org/10.1038/nn1805
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/nri1733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012994687
    231 https://doi.org/10.1038/nri1733
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/nri2038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011537546
    234 https://doi.org/10.1038/nri2038
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/nri2075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051451357
    237 https://doi.org/10.1038/nri2075
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/nrn1195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019705995
    240 https://doi.org/10.1038/nrn1195
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/nrn2038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004977965
    243 https://doi.org/10.1038/nrn2038
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1097/00004647-200011000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000665398
    246 https://doi.org/10.1097/00004647-200011000-00003
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1208/aapsj080369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038414581
    249 https://doi.org/10.1208/aapsj080369
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1002/1521-4141(200107)31:7<2104::aid-immu2104>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025864022
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1002/glia.10057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047994851
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1002/glia.10306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052859344
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1002/glia.20191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015282586
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1002/glia.20332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052285355
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1002/glia.20459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026085963
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1002/glia.20462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044029315
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1002/glia.20468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040216532
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1002/glia.20535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035461514
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1002/jnr.10637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030018242
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1002/jnr.1198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046761722
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1002/jnr.20482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038504595
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1002/jnr.20562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031511080
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1002/jnr.20659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047386904
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1006/exnr.2000.7618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036815072
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/0166-2236(96)10049-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019601232
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/0306-4522(92)90500-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034836912
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.brainresrev.2004.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039684183
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/j.brainresrev.2006.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009705897
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/j.brainresrev.2007.03.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016568416
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/j.febslet.2007.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042207199
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/j.it.2006.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051587674
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/j.mcn.2005.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046367844
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/j.mcn.2005.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040513941
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/j.mcn.2007.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016603934
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/j.nbd.2003.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008876601
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/j.nbd.2004.09.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049109059
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/j.neuroscience.2007.02.055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005441422
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/j.tins.2005.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002770331
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/j.tins.2006.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023597634
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/s0165-0173(99)00024-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040838990
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/s0165-5728(00)00239-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037802785
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/s0169-328x(99)00016-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023105610
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/s0896-6273(04)00069-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008621909
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/s0969-9961(02)00008-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043370342
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/s1074-7613(00)00023-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012421191
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1038/sj.jcbfm.9600362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045734412
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1038/sj.jcbfm.9600495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050300590
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1046/j.0953-816x.2001.01793.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035209840
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1046/j.1460-9568.2002.02287.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006233991
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1046/j.1460-9568.2003.02663.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004804463
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1073/pnas.2234031100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039848645
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1073/pnas.94.8.4080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029885226
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1076/jhin.11.4.325.8531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033242913
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1084/jem.172.4.1025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030148652
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1084/jem.20051529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020464518
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1091/mbc.e06-10-0975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031104672
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1093/brain/awf015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053412776
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1093/brain/awl206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015927577
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1093/brain/awl263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019270489
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1096/fj.04-1517fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1007570139
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1096/fj.05-5106com schema:sameAs https://app.dimensions.ai/details/publication/pub.1041184828
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1097/00004647-200011000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000665398
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1097/01.jnen.0000178445.33972.a9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060330607
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1111/j.1365-2249.2005.02934.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035252138
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1111/j.1471-4159.2004.02954.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020344444
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1126/science.1088417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034380276
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1126/science.1092864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062449226
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1126/science.1110647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047502402
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1126/science.290.5497.1768 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062572307
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1158/0008-5472.can-06-0365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019019177
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1172/jci26836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022644985
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1177/135245850000600108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063988606
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1189/jlb.0504272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008662355
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1248/bpb.25.945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025799441
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1254/jphs.94.203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045838866
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1515/revneuro.2002.13.3.221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031122800
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1523/jneurosci.16-08-02508.1996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082954712
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1523/jneurosci.1808-05.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008184119
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1523/jneurosci.2275-06.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016058842
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1523/jneurosci.2451-04.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031774215
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1523/jneurosci.2531-06.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042530449
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1523/jneurosci.4371-06.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006115366
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1523/jneurosci.4540-04.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049775522
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1523/jneurosci.5321-06.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033008560
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1523/jneurosci.5360-06.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048131984
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.4049/jimmunol.167.9.5004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074944291
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.4049/jimmunol.172.11.7144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076842257
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.4049/jimmunol.173.6.3916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008927643
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.4049/jimmunol.175.1.342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034427592
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.4049/jimmunol.177.4.2051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002279127
    412 rdf:type schema:CreativeWork
    413 https://www.grid.ac/institutes/grid.419491.0 schema:alternateName Max Delbrück Center for Molecular Medicine
    414 schema:name Cellular Neuroscience, Max Delbrück Center for Molecular Medicine, Robert-Rössle-Straße 10, D-13092 Berlin, Germany.
    415 rdf:type schema:Organization
    416 https://www.grid.ac/institutes/grid.7450.6 schema:alternateName University of Göttingen
    417 schema:name Institute of Neuropathology, University of Göttingen, Robert-Koch-Straße 40, D-37075 Göttingen, Germany.
    418 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...