Ontology type: schema:ScholarlyArticle
2007-11
AUTHORSJohn Jacob, Anna L Ferri, Christopher Milton, Fabrice Prin, Patrick Pla, Wei Lin, Anthony Gavalas, Siew-Lan Ang, James Briscoe
ABSTRACTIn many regions of the developing CNS, distinct cell types are born at different times. The means by which discrete and stereotyped temporal switches in cellular identities are acquired remains poorly understood. To address this, we have examined how visceral motor neurons (VMNs) and serotonergic neurons, two neuronal subtypes, are sequentially generated from a common progenitor pool in the vertebrate hindbrain. We found that the forkhead transcription factor Foxa2, acting in progenitors, is essential for the transition from VMN to serotonergic neurogenesis. Loss-of-function and gain-of-function experiments indicated that Foxa2 activates the switch through a temporal cross-repressive interaction with paired-like homeobox 2b (Phox2b), the VMN progenitor determinant. This mechanism bears a marked resemblance to the cross-repression between neighboring domains of transcription factors that establish discrete progenitor identities along the spatial axes. Moreover, the subsequent differentiation of central serotonergic neurons required both the suppression of VMN neurogenesis and the induction of downstream intrinsic determinants of serotonergic identity by Foxa2. More... »
PAGES1433-1439
http://scigraph.springernature.com/pub.10.1038/nn1985
DOIhttp://dx.doi.org/10.1038/nn1985
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/17922007
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"sameAs": [
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],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T18:56",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
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"type": "ScholarlyArticle",
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]Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nn1985'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nn1985'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nn1985'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nn1985'
This table displays all metadata directly associated to this object as RDF triples.
360 TRIPLES
21 PREDICATES
99 URIs
41 LITERALS
29 BLANK NODES