Caenorhabditis elegans TRPA-1 functions in mechanosensation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-04-22

AUTHORS

Katie S Kindt, Veena Viswanath, Lindsey Macpherson, Kathleen Quast, Hongzhen Hu, Ardem Patapoutian, William R Schafer

ABSTRACT

Members of the transient receptor potential (TRP) ion channel family mediate diverse sensory transduction processes in both vertebrates and invertebrates. In particular, members of the TRPA subfamily have distinct thermosensory roles in Drosophila, and mammalian TRPA1 is postulated to have a function in noxious cold sensation and mechanosensation. Here we show that mutations in trpa-1, the C. elegans ortholog of mouse Trpa1, confer specific defects in mechanosensory behaviors related to nose-touch responses and foraging. trpa-1 is expressed and functions in sensory neurons required for these mechanosensory behaviors, and contributes to neural responses of these cells to touch, particularly after repeated mechanical stimulation. Furthermore, mechanical pressure can activate C. elegans TRPA-1 heterologously expressed in mammalian cells. Collectively, these data demonstrate that trpa-1 encodes an ion channel that can be activated in response to mechanical pressure and is required for mechanosensory neuron function, suggesting a possible role in mechanosensory transduction or modulation. More... »

PAGES

568-577

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn1886

DOI

http://dx.doi.org/10.1038/nn1886

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031553419

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17450139


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals, Genetically Modified", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CHO Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caenorhabditis elegans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caenorhabditis elegans Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cricetinae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cricetulus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Green Fluorescent Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Head Movements", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mechanoreceptors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mechanotransduction, Cellular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Potentials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons, Afferent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Patch-Clamp Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reflex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Touch", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transient Receptor Potential Channels", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Biology, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.266100.3", 
          "name": [
            "MRC Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK", 
            "Division of Biology, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kindt", 
        "givenName": "Katie S", 
        "id": "sg:person.01264104107.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264104107.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Present address: Allergan, Inc., 2525 Dupont Drive, Irvine, California 92623, USA.", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Genomics Institute of the Novartis Research Foundation, 10675 John Hopkins Road, 92121, San Diego, California, USA", 
            "Present address: Allergan, Inc., 2525 Dupont Drive, Irvine, California 92623, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Viswanath", 
        "givenName": "Veena", 
        "id": "sg:person.01055260342.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055260342.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cell Biology, ICND202, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.214007.0", 
          "name": [
            "Department of Cell Biology, ICND202, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Macpherson", 
        "givenName": "Lindsey", 
        "id": "sg:person.01314650770.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314650770.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Biology, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.266100.3", 
          "name": [
            "Division of Biology, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Quast", 
        "givenName": "Kathleen", 
        "id": "sg:person.01215152334.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215152334.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genomics Institute of the Novartis Research Foundation, 10675 John Hopkins Road, 92121, San Diego, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.418185.1", 
          "name": [
            "Genomics Institute of the Novartis Research Foundation, 10675 John Hopkins Road, 92121, San Diego, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hu", 
        "givenName": "Hongzhen", 
        "id": "sg:person.016245602762.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016245602762.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cell Biology, ICND202, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.214007.0", 
          "name": [
            "Genomics Institute of the Novartis Research Foundation, 10675 John Hopkins Road, 92121, San Diego, California, USA", 
            "Department of Cell Biology, ICND202, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Patapoutian", 
        "givenName": "Ardem", 
        "id": "sg:person.01367225306.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367225306.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Biology, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.266100.3", 
          "name": [
            "MRC Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK", 
            "Division of Biology, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schafer", 
        "givenName": "William R", 
        "id": "sg:person.016032615777.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016032615777.05"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ng1513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017245930", 
          "https://doi.org/10.1038/ng1513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1362", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004779862", 
          "https://doi.org/10.1038/nn1362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/4151039a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044277491", 
          "https://doi.org/10.1038/4151039a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039689814", 
          "https://doi.org/10.1038/nature03066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1843", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015824551", 
          "https://doi.org/10.1038/nn1843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012032691", 
          "https://doi.org/10.1038/nn1347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn1141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004168886", 
          "https://doi.org/10.1038/nrn1141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020694555", 
          "https://doi.org/10.1038/nature05544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/378082a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020359124", 
          "https://doi.org/10.1038/378082a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025103202", 
          "https://doi.org/10.1038/nbt1037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/423822a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047717110", 
          "https://doi.org/10.1038/423822a"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-04-22", 
    "datePublishedReg": "2007-04-22", 
    "description": "Members of the transient receptor potential (TRP) ion channel family mediate diverse sensory transduction processes in both vertebrates and invertebrates. In particular, members of the TRPA subfamily have distinct thermosensory roles in Drosophila, and mammalian TRPA1 is postulated to have a function in noxious cold sensation and mechanosensation. Here we show that mutations in trpa-1, the C. elegans ortholog of mouse Trpa1, confer specific defects in mechanosensory behaviors related to nose-touch responses and foraging. trpa-1 is expressed and functions in sensory neurons required for these mechanosensory behaviors, and contributes to neural responses of these cells to touch, particularly after repeated mechanical stimulation. Furthermore, mechanical pressure can activate C. elegans TRPA-1 heterologously expressed in mammalian cells. Collectively, these data demonstrate that trpa-1 encodes an ion channel that can be activated in response to mechanical pressure and is required for mechanosensory neuron function, suggesting a possible role in mechanosensory transduction or modulation.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/nn1886", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2491074", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2485605", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2759346", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2485875", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1118362", 
        "issn": [
          "1097-6256", 
          "1546-1726"
        ], 
        "name": "Nature Neuroscience", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "keywords": [
      "TRPA-1", 
      "mechanosensory behaviors", 
      "transient receptor potential (TRP) ion channel family", 
      "ion channel family", 
      "nose touch response", 
      "sensory transduction process", 
      "mammalian cells", 
      "mammalian TRPA1", 
      "transduction processes", 
      "channel family", 
      "mechanosensory transduction", 
      "ion channels", 
      "mouse TRPA1", 
      "specific defects", 
      "mechanosensation", 
      "noxious cold sensation", 
      "possible role", 
      "sensory neurons", 
      "Drosophila", 
      "Caenorhabditis", 
      "neuron function", 
      "elegans", 
      "cold sensation", 
      "vertebrates", 
      "invertebrates", 
      "cells", 
      "foraging", 
      "trpA", 
      "transduction", 
      "mechanical stimulation", 
      "neural responses", 
      "members", 
      "TRPA1", 
      "mutations", 
      "function", 
      "role", 
      "response", 
      "mechanical pressure", 
      "family", 
      "neurons", 
      "stimulation", 
      "sensation", 
      "modulation", 
      "defects", 
      "pressure", 
      "process", 
      "channels", 
      "data", 
      "behavior", 
      "receptor potential (TRP) ion channel family", 
      "potential (TRP) ion channel family", 
      "diverse sensory transduction processes", 
      "distinct thermosensory roles", 
      "thermosensory roles", 
      "confer specific defects", 
      "elegans TRPA-1", 
      "mechanosensory neuron function", 
      "TRPA-1 functions"
    ], 
    "name": "Caenorhabditis elegans TRPA-1 functions in mechanosensation", 
    "pagination": "568-577", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031553419"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nn1886"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17450139"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nn1886", 
      "https://app.dimensions.ai/details/publication/pub.1031553419"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_443.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/nn1886"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nn1886'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nn1886'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nn1886'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nn1886'


 

This table displays all metadata directly associated to this object as RDF triples.

318 TRIPLES      22 PREDICATES      118 URIs      99 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nn1886 schema:about N05600a84b6fe4824815772224768356d
2 N088b56d6f1c941079db7d1f8b5160e4c
3 N0e97943398da448eb40e7e2669a0142d
4 N126f5db2f2694945a39c67995016a40e
5 N14e3fd4934be4f30a72c008d828f0408
6 N2840657b59c947f0a70a8adcc1de101f
7 N2c58c6c2e277446980d7a044ee808232
8 N2c69bf88339c4eb0bc340f57065ae049
9 N48e7374967dd4fa3af72ec54ef9bc415
10 N5a46e34327a64fab9b75eefc1496374e
11 N702acff5859b48f3a830d45e6c1d1f76
12 N7560ba74d5144499834ddba061e3bc50
13 N803c0b809eae47e09249fc909b3c183d
14 N94c2adb443144cb3b559d0da2df45f53
15 N9745fba48db64bfd93b8def0956392e4
16 Nba370c13fdc4454fbb5e0e8f552b0811
17 Nc753c1981935407b9d42cc1625ba391d
18 Nd53b73633f8b4502998d4e032434e1ec
19 Nd7d40d23add2474e8dc46e681f8b0acc
20 Ndbb582d98b6b465eb46df3692c7295e9
21 Nde2abc3e031944fb9fe90683b58bde47
22 Ne536059c53d042bda34d1ee9105c7415
23 Nfe12e52f9bd84f079d19166070cee5b8
24 anzsrc-for:11
25 anzsrc-for:1109
26 schema:author Nb07d8130b5544b0ebe04d9be02e0a419
27 schema:citation sg:pub.10.1038/378082a0
28 sg:pub.10.1038/4151039a
29 sg:pub.10.1038/423822a
30 sg:pub.10.1038/nature03066
31 sg:pub.10.1038/nature05544
32 sg:pub.10.1038/nbt1037
33 sg:pub.10.1038/ng1513
34 sg:pub.10.1038/nn1347
35 sg:pub.10.1038/nn1362
36 sg:pub.10.1038/nn1843
37 sg:pub.10.1038/nrn1141
38 schema:datePublished 2007-04-22
39 schema:datePublishedReg 2007-04-22
40 schema:description Members of the transient receptor potential (TRP) ion channel family mediate diverse sensory transduction processes in both vertebrates and invertebrates. In particular, members of the TRPA subfamily have distinct thermosensory roles in Drosophila, and mammalian TRPA1 is postulated to have a function in noxious cold sensation and mechanosensation. Here we show that mutations in trpa-1, the C. elegans ortholog of mouse Trpa1, confer specific defects in mechanosensory behaviors related to nose-touch responses and foraging. trpa-1 is expressed and functions in sensory neurons required for these mechanosensory behaviors, and contributes to neural responses of these cells to touch, particularly after repeated mechanical stimulation. Furthermore, mechanical pressure can activate C. elegans TRPA-1 heterologously expressed in mammalian cells. Collectively, these data demonstrate that trpa-1 encodes an ion channel that can be activated in response to mechanical pressure and is required for mechanosensory neuron function, suggesting a possible role in mechanosensory transduction or modulation.
41 schema:genre article
42 schema:inLanguage en
43 schema:isAccessibleForFree false
44 schema:isPartOf N84cd89cc2f2f4e03b7d5b43210c16369
45 Na1f01140e268444da4bc3f46fc7ba1a2
46 sg:journal.1118362
47 schema:keywords Caenorhabditis
48 Drosophila
49 TRPA-1
50 TRPA-1 functions
51 TRPA1
52 behavior
53 cells
54 channel family
55 channels
56 cold sensation
57 confer specific defects
58 data
59 defects
60 distinct thermosensory roles
61 diverse sensory transduction processes
62 elegans
63 elegans TRPA-1
64 family
65 foraging
66 function
67 invertebrates
68 ion channel family
69 ion channels
70 mammalian TRPA1
71 mammalian cells
72 mechanical pressure
73 mechanical stimulation
74 mechanosensation
75 mechanosensory behaviors
76 mechanosensory neuron function
77 mechanosensory transduction
78 members
79 modulation
80 mouse TRPA1
81 mutations
82 neural responses
83 neuron function
84 neurons
85 nose touch response
86 noxious cold sensation
87 possible role
88 potential (TRP) ion channel family
89 pressure
90 process
91 receptor potential (TRP) ion channel family
92 response
93 role
94 sensation
95 sensory neurons
96 sensory transduction process
97 specific defects
98 stimulation
99 thermosensory roles
100 transduction
101 transduction processes
102 transient receptor potential (TRP) ion channel family
103 trpA
104 vertebrates
105 schema:name Caenorhabditis elegans TRPA-1 functions in mechanosensation
106 schema:pagination 568-577
107 schema:productId N85db3b3930454c5ea33baaef2ef5bf84
108 Nc3ec043bb7094fb7821c1bb40161e55f
109 Nee2cf0a10d3d47a2be207f9153655b29
110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031553419
111 https://doi.org/10.1038/nn1886
112 schema:sdDatePublished 2022-01-01T18:17
113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
114 schema:sdPublisher N2a9af3d695134207ad4b9ed4d8d4c172
115 schema:url https://doi.org/10.1038/nn1886
116 sgo:license sg:explorer/license/
117 sgo:sdDataset articles
118 rdf:type schema:ScholarlyArticle
119 N05600a84b6fe4824815772224768356d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Cricetinae
121 rdf:type schema:DefinedTerm
122 N088b56d6f1c941079db7d1f8b5160e4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Transient Receptor Potential Channels
124 rdf:type schema:DefinedTerm
125 N0e97943398da448eb40e7e2669a0142d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Mutation
127 rdf:type schema:DefinedTerm
128 N126f5db2f2694945a39c67995016a40e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Membrane Potentials
130 rdf:type schema:DefinedTerm
131 N14e3fd4934be4f30a72c008d828f0408 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Mechanoreceptors
133 rdf:type schema:DefinedTerm
134 N1e10044b51ca4c4281d5b767022de9c6 rdf:first sg:person.01215152334.48
135 rdf:rest Nfaac95ff9bbf4f0cb5c65a78075bd395
136 N2840657b59c947f0a70a8adcc1de101f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Caenorhabditis elegans Proteins
138 rdf:type schema:DefinedTerm
139 N2a9af3d695134207ad4b9ed4d8d4c172 schema:name Springer Nature - SN SciGraph project
140 rdf:type schema:Organization
141 N2c58c6c2e277446980d7a044ee808232 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Transfection
143 rdf:type schema:DefinedTerm
144 N2c69bf88339c4eb0bc340f57065ae049 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Mice
146 rdf:type schema:DefinedTerm
147 N48e7374967dd4fa3af72ec54ef9bc415 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Reflex
149 rdf:type schema:DefinedTerm
150 N5a46e34327a64fab9b75eefc1496374e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Molecular Sequence Data
152 rdf:type schema:DefinedTerm
153 N702acff5859b48f3a830d45e6c1d1f76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Animals, Genetically Modified
155 rdf:type schema:DefinedTerm
156 N7560ba74d5144499834ddba061e3bc50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Head Movements
158 rdf:type schema:DefinedTerm
159 N7b0f715f1896451484b16f46f7ee4a86 rdf:first sg:person.01367225306.34
160 rdf:rest Nf40eeafd894545f8af10df88fc64cf02
161 N803c0b809eae47e09249fc909b3c183d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Touch
163 rdf:type schema:DefinedTerm
164 N84cd89cc2f2f4e03b7d5b43210c16369 schema:issueNumber 5
165 rdf:type schema:PublicationIssue
166 N85db3b3930454c5ea33baaef2ef5bf84 schema:name doi
167 schema:value 10.1038/nn1886
168 rdf:type schema:PropertyValue
169 N94c2adb443144cb3b559d0da2df45f53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Models, Biological
171 rdf:type schema:DefinedTerm
172 N9745fba48db64bfd93b8def0956392e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Green Fluorescent Proteins
174 rdf:type schema:DefinedTerm
175 Na1f01140e268444da4bc3f46fc7ba1a2 schema:volumeNumber 10
176 rdf:type schema:PublicationVolume
177 Nb07d8130b5544b0ebe04d9be02e0a419 rdf:first sg:person.01264104107.28
178 rdf:rest Nba626f4a14c246aca8a7b50109714fb9
179 Nba370c13fdc4454fbb5e0e8f552b0811 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Cricetulus
181 rdf:type schema:DefinedTerm
182 Nba626f4a14c246aca8a7b50109714fb9 rdf:first sg:person.01055260342.20
183 rdf:rest Nde555fd89b91475187f67d18850fccf9
184 Nc3ec043bb7094fb7821c1bb40161e55f schema:name pubmed_id
185 schema:value 17450139
186 rdf:type schema:PropertyValue
187 Nc753c1981935407b9d42cc1625ba391d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Mechanotransduction, Cellular
189 rdf:type schema:DefinedTerm
190 Nd53b73633f8b4502998d4e032434e1ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name CHO Cells
192 rdf:type schema:DefinedTerm
193 Nd7d40d23add2474e8dc46e681f8b0acc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Gene Expression
195 rdf:type schema:DefinedTerm
196 Ndbb582d98b6b465eb46df3692c7295e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Patch-Clamp Techniques
198 rdf:type schema:DefinedTerm
199 Nde2abc3e031944fb9fe90683b58bde47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Caenorhabditis elegans
201 rdf:type schema:DefinedTerm
202 Nde555fd89b91475187f67d18850fccf9 rdf:first sg:person.01314650770.54
203 rdf:rest N1e10044b51ca4c4281d5b767022de9c6
204 Ne536059c53d042bda34d1ee9105c7415 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Animals
206 rdf:type schema:DefinedTerm
207 Nee2cf0a10d3d47a2be207f9153655b29 schema:name dimensions_id
208 schema:value pub.1031553419
209 rdf:type schema:PropertyValue
210 Nf40eeafd894545f8af10df88fc64cf02 rdf:first sg:person.016032615777.05
211 rdf:rest rdf:nil
212 Nfaac95ff9bbf4f0cb5c65a78075bd395 rdf:first sg:person.016245602762.57
213 rdf:rest N7b0f715f1896451484b16f46f7ee4a86
214 Nfe12e52f9bd84f079d19166070cee5b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Neurons, Afferent
216 rdf:type schema:DefinedTerm
217 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
218 schema:name Medical and Health Sciences
219 rdf:type schema:DefinedTerm
220 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
221 schema:name Neurosciences
222 rdf:type schema:DefinedTerm
223 sg:grant.2485605 http://pending.schema.org/fundedItem sg:pub.10.1038/nn1886
224 rdf:type schema:MonetaryGrant
225 sg:grant.2485875 http://pending.schema.org/fundedItem sg:pub.10.1038/nn1886
226 rdf:type schema:MonetaryGrant
227 sg:grant.2491074 http://pending.schema.org/fundedItem sg:pub.10.1038/nn1886
228 rdf:type schema:MonetaryGrant
229 sg:grant.2759346 http://pending.schema.org/fundedItem sg:pub.10.1038/nn1886
230 rdf:type schema:MonetaryGrant
231 sg:journal.1118362 schema:issn 1097-6256
232 1546-1726
233 schema:name Nature Neuroscience
234 schema:publisher Springer Nature
235 rdf:type schema:Periodical
236 sg:person.01055260342.20 schema:affiliation grid-institutes:None
237 schema:familyName Viswanath
238 schema:givenName Veena
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055260342.20
240 rdf:type schema:Person
241 sg:person.01215152334.48 schema:affiliation grid-institutes:grid.266100.3
242 schema:familyName Quast
243 schema:givenName Kathleen
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215152334.48
245 rdf:type schema:Person
246 sg:person.01264104107.28 schema:affiliation grid-institutes:grid.266100.3
247 schema:familyName Kindt
248 schema:givenName Katie S
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264104107.28
250 rdf:type schema:Person
251 sg:person.01314650770.54 schema:affiliation grid-institutes:grid.214007.0
252 schema:familyName Macpherson
253 schema:givenName Lindsey
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314650770.54
255 rdf:type schema:Person
256 sg:person.01367225306.34 schema:affiliation grid-institutes:grid.214007.0
257 schema:familyName Patapoutian
258 schema:givenName Ardem
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367225306.34
260 rdf:type schema:Person
261 sg:person.016032615777.05 schema:affiliation grid-institutes:grid.266100.3
262 schema:familyName Schafer
263 schema:givenName William R
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016032615777.05
265 rdf:type schema:Person
266 sg:person.016245602762.57 schema:affiliation grid-institutes:grid.418185.1
267 schema:familyName Hu
268 schema:givenName Hongzhen
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016245602762.57
270 rdf:type schema:Person
271 sg:pub.10.1038/378082a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020359124
272 https://doi.org/10.1038/378082a0
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/4151039a schema:sameAs https://app.dimensions.ai/details/publication/pub.1044277491
275 https://doi.org/10.1038/4151039a
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/423822a schema:sameAs https://app.dimensions.ai/details/publication/pub.1047717110
278 https://doi.org/10.1038/423822a
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/nature03066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039689814
281 https://doi.org/10.1038/nature03066
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/nature05544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020694555
284 https://doi.org/10.1038/nature05544
285 rdf:type schema:CreativeWork
286 sg:pub.10.1038/nbt1037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025103202
287 https://doi.org/10.1038/nbt1037
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/ng1513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017245930
290 https://doi.org/10.1038/ng1513
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/nn1347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012032691
293 https://doi.org/10.1038/nn1347
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/nn1362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004779862
296 https://doi.org/10.1038/nn1362
297 rdf:type schema:CreativeWork
298 sg:pub.10.1038/nn1843 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015824551
299 https://doi.org/10.1038/nn1843
300 rdf:type schema:CreativeWork
301 sg:pub.10.1038/nrn1141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004168886
302 https://doi.org/10.1038/nrn1141
303 rdf:type schema:CreativeWork
304 grid-institutes:None schema:alternateName Present address: Allergan, Inc., 2525 Dupont Drive, Irvine, California 92623, USA.
305 schema:name Genomics Institute of the Novartis Research Foundation, 10675 John Hopkins Road, 92121, San Diego, California, USA
306 Present address: Allergan, Inc., 2525 Dupont Drive, Irvine, California 92623, USA.
307 rdf:type schema:Organization
308 grid-institutes:grid.214007.0 schema:alternateName Department of Cell Biology, ICND202, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, California, USA
309 schema:name Department of Cell Biology, ICND202, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, California, USA
310 Genomics Institute of the Novartis Research Foundation, 10675 John Hopkins Road, 92121, San Diego, California, USA
311 rdf:type schema:Organization
312 grid-institutes:grid.266100.3 schema:alternateName Division of Biology, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, California, USA
313 schema:name Division of Biology, University of California, San Diego, 9500 Gilman Drive, 92093, La Jolla, California, USA
314 MRC Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK
315 rdf:type schema:Organization
316 grid-institutes:grid.418185.1 schema:alternateName Genomics Institute of the Novartis Research Foundation, 10675 John Hopkins Road, 92121, San Diego, California, USA
317 schema:name Genomics Institute of the Novartis Research Foundation, 10675 John Hopkins Road, 92121, San Diego, California, USA
318 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...