Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-03

AUTHORS

Inmaculada Segura, Clara L Essmann, Stefan Weinges, Amparo Acker-Palmer

ABSTRACT

Dendritic spines are small protrusions emerging from dendrites that receive excitatory input. The process of spine morphogenesis occurs both in the developing brain and during synaptic plasticity. Molecules regulating the cytoskeleton are involved in spine formation and maintenance. Here we show that reverse signaling by the transmembrane ligands for Eph receptors, ephrinBs, is required for correct spine morphogenesis. The molecular mechanism underlying this function of ephrinBs involves the SH2 and SH3 domain-containing adaptor protein Grb4 and the G protein-coupled receptor kinase-interacting protein (GIT) 1. Grb4 binds by its SH2 domain to Tyr392 in the synaptic localization domain of GIT1. Phosphorylation of Tyr392 and the recruitment of GIT1 to synapses are regulated by ephrinB activation. Disruption of this pathway in cultured rat hippocampal neurons impairs spine morphogenesis and synapse formation. We thus show an important role for ephrinB reverse signaling in spine formation and have mapped the downstream pathway involved in this process. More... »

PAGES

301-310

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn1858

DOI

http://dx.doi.org/10.1038/nn1858

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042268473

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17310244


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adaptor Proteins, Signal Transducing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dendritic Spines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryo, Mammalian", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hippocampus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Luminescent Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutagenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Eph Family", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Synapses", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Max Planck Institute of Neurobiology", 
          "id": "https://www.grid.ac/institutes/grid.429510.b", 
          "name": [
            "Max-Planck Institute of Neurobiology, Am Klopferspitz 18, D-82152 Martinsried, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Segura", 
        "givenName": "Inmaculada", 
        "id": "sg:person.0771157447.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771157447.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute of Neurobiology", 
          "id": "https://www.grid.ac/institutes/grid.429510.b", 
          "name": [
            "Max-Planck Institute of Neurobiology, Am Klopferspitz 18, D-82152 Martinsried, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Essmann", 
        "givenName": "Clara L", 
        "id": "sg:person.01104631153.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104631153.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute of Neurobiology", 
          "id": "https://www.grid.ac/institutes/grid.429510.b", 
          "name": [
            "Max-Planck Institute of Neurobiology, Am Klopferspitz 18, D-82152 Martinsried, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weinges", 
        "givenName": "Stefan", 
        "id": "sg:person.01105406047.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105406047.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute of Neurobiology", 
          "id": "https://www.grid.ac/institutes/grid.429510.b", 
          "name": [
            "Max-Planck Institute of Neurobiology, Am Klopferspitz 18, D-82152 Martinsried, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Acker-Palmer", 
        "givenName": "Amparo", 
        "id": "sg:person.01335633713.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335633713.09"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1146/annurev.physiol.64.081501.160008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008031532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/89460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010430249", 
          "https://doi.org/10.1038/89460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/89460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010430249", 
          "https://doi.org/10.1038/89460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200306033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013138593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3553-04.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015330407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35093123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016114423", 
          "https://doi.org/10.1038/35093123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35093123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016114423", 
          "https://doi.org/10.1038/35093123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.9.5542", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023676759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1432-1033.2003.03428.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025052726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.144.3.575", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025546421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m307317200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026594183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.neuro.24.1.1071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027559872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.4338-05.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028081486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m511756200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028709307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m511756200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028709307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(01)00550-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030069210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032251157", 
          "https://doi.org/10.1038/nn964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032251157", 
          "https://doi.org/10.1038/nn964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.20.17.6354-6363.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032566018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.12.5.667", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033186233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(01)00553-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036992935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037079838", 
          "https://doi.org/10.1038/nn994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037079838", 
          "https://doi.org/10.1038/nn994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(02)00488-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040536139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041018583", 
          "https://doi.org/10.1038/ncb1045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041018583", 
          "https://doi.org/10.1038/ncb1045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)00197-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044793043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(01)00440-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046368936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e05-02-0131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046630906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e05-02-0131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046630906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90404-e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048620882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-6273(92)90245-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048967754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050119611", 
          "https://doi.org/10.1038/nature01273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050119611", 
          "https://doi.org/10.1038/nature01273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200211002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050377448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.3.1303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051210034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051258574", 
          "https://doi.org/10.1038/nn1164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051258574", 
          "https://doi.org/10.1038/nn1164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(02)01168-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052312721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.23.13438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052331357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053258316", 
          "https://doi.org/10.1038/nn1487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053258316", 
          "https://doi.org/10.1038/nn1487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053258316", 
          "https://doi.org/10.1038/nn1487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1069081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062445879"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-03", 
    "datePublishedReg": "2007-03-01", 
    "description": "Dendritic spines are small protrusions emerging from dendrites that receive excitatory input. The process of spine morphogenesis occurs both in the developing brain and during synaptic plasticity. Molecules regulating the cytoskeleton are involved in spine formation and maintenance. Here we show that reverse signaling by the transmembrane ligands for Eph receptors, ephrinBs, is required for correct spine morphogenesis. The molecular mechanism underlying this function of ephrinBs involves the SH2 and SH3 domain-containing adaptor protein Grb4 and the G protein-coupled receptor kinase-interacting protein (GIT) 1. Grb4 binds by its SH2 domain to Tyr392 in the synaptic localization domain of GIT1. Phosphorylation of Tyr392 and the recruitment of GIT1 to synapses are regulated by ephrinB activation. Disruption of this pathway in cultured rat hippocampal neurons impairs spine morphogenesis and synapse formation. We thus show an important role for ephrinB reverse signaling in spine formation and have mapped the downstream pathway involved in this process.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nn1858", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1118362", 
        "issn": [
          "1097-6256", 
          "1546-1726"
        ], 
        "name": "Nature Neuroscience", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation", 
    "pagination": "301-310", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c9589a76239ebeab93305182f0a5ccc8472a881fe572caa7898045813595f0a2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17310244"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9809671"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nn1858"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1042268473"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nn1858", 
      "https://app.dimensions.ai/details/publication/pub.1042268473"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:45", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/nn1858"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nn1858'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nn1858'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nn1858'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nn1858'


 

This table displays all metadata directly associated to this object as RDF triples.

277 TRIPLES      21 PREDICATES      82 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nn1858 schema:about N01216e1314924e1e8c9c8fb9a5e095be
2 N039417c584644437bf1e6fdbd28041a8
3 N065b98838e5d4f7495a8ce06a063db23
4 N0d7c534982214691abd2a6b1585492c4
5 N160046c5c7b443b385989f4bad109e49
6 N169ba41c2bc249618a3066806b9b82f7
7 N1cf32af604704839874a28f84b9a6b0c
8 N1f91e4e29d344723b22eff8efa819a60
9 N4ff7c963f182417aa5001b029baf43fb
10 N51e3e5f5796c4853b5ccf1c1c20f486d
11 N583f12b64b7a4227a42474ad6c812644
12 N5c4d3376e199435696e99bd29bcdd657
13 N5d175edf7c3e4b57811c91490c989701
14 N65de51044b1645fc9fe6d6e3cbd90655
15 N70d3f7471d4c42fab76ac4ba391bb500
16 N7620f08e26f34fcf939f1367f5fd4de7
17 N7831bbc7f0b549abb2d232f607b25166
18 Na5708970751c430ebe7732be0d408711
19 Nb3bb05ae57f04df2bf43cf64530169aa
20 Nd0b55b47bbfd4ce184db3b9a88af48fa
21 anzsrc-for:06
22 anzsrc-for:0601
23 schema:author N6e19e57120274900bfa2a2f46df86f27
24 schema:citation sg:pub.10.1038/35093123
25 sg:pub.10.1038/89460
26 sg:pub.10.1038/nature01273
27 sg:pub.10.1038/ncb1045
28 sg:pub.10.1038/nn1164
29 sg:pub.10.1038/nn1487
30 sg:pub.10.1038/nn964
31 sg:pub.10.1038/nn994
32 https://doi.org/10.1016/0092-8674(93)90404-e
33 https://doi.org/10.1016/0896-6273(92)90245-9
34 https://doi.org/10.1016/s0092-8674(00)00197-5
35 https://doi.org/10.1016/s0896-6273(01)00440-8
36 https://doi.org/10.1016/s0896-6273(01)00550-5
37 https://doi.org/10.1016/s0896-6273(01)00553-0
38 https://doi.org/10.1016/s0896-6273(02)01168-6
39 https://doi.org/10.1016/s1097-2765(02)00488-4
40 https://doi.org/10.1046/j.1432-1033.2003.03428.x
41 https://doi.org/10.1073/pnas.96.23.13438
42 https://doi.org/10.1074/jbc.273.3.1303
43 https://doi.org/10.1074/jbc.274.9.5542
44 https://doi.org/10.1074/jbc.m307317200
45 https://doi.org/10.1074/jbc.m511756200
46 https://doi.org/10.1083/jcb.144.3.575
47 https://doi.org/10.1083/jcb.200211002
48 https://doi.org/10.1083/jcb.200306033
49 https://doi.org/10.1091/mbc.e05-02-0131
50 https://doi.org/10.1101/gad.12.5.667
51 https://doi.org/10.1126/science.1069081
52 https://doi.org/10.1128/mcb.20.17.6354-6363.2000
53 https://doi.org/10.1146/annurev.neuro.24.1.1071
54 https://doi.org/10.1146/annurev.physiol.64.081501.160008
55 https://doi.org/10.1523/jneurosci.3553-04.2005
56 https://doi.org/10.1523/jneurosci.4338-05.2006
57 schema:datePublished 2007-03
58 schema:datePublishedReg 2007-03-01
59 schema:description Dendritic spines are small protrusions emerging from dendrites that receive excitatory input. The process of spine morphogenesis occurs both in the developing brain and during synaptic plasticity. Molecules regulating the cytoskeleton are involved in spine formation and maintenance. Here we show that reverse signaling by the transmembrane ligands for Eph receptors, ephrinBs, is required for correct spine morphogenesis. The molecular mechanism underlying this function of ephrinBs involves the SH2 and SH3 domain-containing adaptor protein Grb4 and the G protein-coupled receptor kinase-interacting protein (GIT) 1. Grb4 binds by its SH2 domain to Tyr392 in the synaptic localization domain of GIT1. Phosphorylation of Tyr392 and the recruitment of GIT1 to synapses are regulated by ephrinB activation. Disruption of this pathway in cultured rat hippocampal neurons impairs spine morphogenesis and synapse formation. We thus show an important role for ephrinB reverse signaling in spine formation and have mapped the downstream pathway involved in this process.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree false
63 schema:isPartOf N1092bbbbabaf456aa15afd864b3ae7b7
64 N1fc538f12f2e4e5fb144002a2237a0e6
65 sg:journal.1118362
66 schema:name Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation
67 schema:pagination 301-310
68 schema:productId N51f92851f96b43059e00acf8117e3293
69 N5804af87af00411d890e5c3c53e1a8ca
70 N61b945ed253d42f4996316be17d47699
71 Nad1602a8849b40fb9d4df6c9e6ac5cc2
72 Nc58234cf62b84572bb09d93df717b75f
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042268473
74 https://doi.org/10.1038/nn1858
75 schema:sdDatePublished 2019-04-10T19:45
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher N72bf165d9bee46579f55e56723de3cfe
78 schema:url http://www.nature.com/articles/nn1858
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N01216e1314924e1e8c9c8fb9a5e095be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Membrane Proteins
84 rdf:type schema:DefinedTerm
85 N039417c584644437bf1e6fdbd28041a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Oncogene Proteins
87 rdf:type schema:DefinedTerm
88 N065b98838e5d4f7495a8ce06a063db23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Luminescent Proteins
90 rdf:type schema:DefinedTerm
91 N0d7c534982214691abd2a6b1585492c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Mutagenesis
93 rdf:type schema:DefinedTerm
94 N1092bbbbabaf456aa15afd864b3ae7b7 schema:issueNumber 3
95 rdf:type schema:PublicationIssue
96 N160046c5c7b443b385989f4bad109e49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Signal Transduction
98 rdf:type schema:DefinedTerm
99 N169ba41c2bc249618a3066806b9b82f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Synapses
101 rdf:type schema:DefinedTerm
102 N1cf32af604704839874a28f84b9a6b0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Cell Cycle Proteins
104 rdf:type schema:DefinedTerm
105 N1f91e4e29d344723b22eff8efa819a60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Transfection
107 rdf:type schema:DefinedTerm
108 N1fc538f12f2e4e5fb144002a2237a0e6 schema:volumeNumber 10
109 rdf:type schema:PublicationVolume
110 N46318d1354fc4f428348b4de496df3c0 rdf:first sg:person.01105406047.44
111 rdf:rest N77c77bebc8014a8da100d8b58db6d9f7
112 N4ff7c963f182417aa5001b029baf43fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Receptors, Eph Family
114 rdf:type schema:DefinedTerm
115 N51e3e5f5796c4853b5ccf1c1c20f486d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Time Factors
117 rdf:type schema:DefinedTerm
118 N51f92851f96b43059e00acf8117e3293 schema:name pubmed_id
119 schema:value 17310244
120 rdf:type schema:PropertyValue
121 N5804af87af00411d890e5c3c53e1a8ca schema:name dimensions_id
122 schema:value pub.1042268473
123 rdf:type schema:PropertyValue
124 N583f12b64b7a4227a42474ad6c812644 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Humans
126 rdf:type schema:DefinedTerm
127 N5c4d3376e199435696e99bd29bcdd657 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Cells, Cultured
129 rdf:type schema:DefinedTerm
130 N5d175edf7c3e4b57811c91490c989701 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Animals
132 rdf:type schema:DefinedTerm
133 N61b945ed253d42f4996316be17d47699 schema:name doi
134 schema:value 10.1038/nn1858
135 rdf:type schema:PropertyValue
136 N65de51044b1645fc9fe6d6e3cbd90655 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Neurons
138 rdf:type schema:DefinedTerm
139 N65ebe8e4454b4dc699ba2cbe21da86e5 rdf:first sg:person.01104631153.09
140 rdf:rest N46318d1354fc4f428348b4de496df3c0
141 N6e19e57120274900bfa2a2f46df86f27 rdf:first sg:person.0771157447.01
142 rdf:rest N65ebe8e4454b4dc699ba2cbe21da86e5
143 N70d3f7471d4c42fab76ac4ba391bb500 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Embryo, Mammalian
145 rdf:type schema:DefinedTerm
146 N72bf165d9bee46579f55e56723de3cfe schema:name Springer Nature - SN SciGraph project
147 rdf:type schema:Organization
148 N7620f08e26f34fcf939f1367f5fd4de7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Dendritic Spines
150 rdf:type schema:DefinedTerm
151 N77c77bebc8014a8da100d8b58db6d9f7 rdf:first sg:person.01335633713.09
152 rdf:rest rdf:nil
153 N7831bbc7f0b549abb2d232f607b25166 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Rats, Sprague-Dawley
155 rdf:type schema:DefinedTerm
156 Na5708970751c430ebe7732be0d408711 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Hippocampus
158 rdf:type schema:DefinedTerm
159 Nad1602a8849b40fb9d4df6c9e6ac5cc2 schema:name nlm_unique_id
160 schema:value 9809671
161 rdf:type schema:PropertyValue
162 Nb3bb05ae57f04df2bf43cf64530169aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Rats
164 rdf:type schema:DefinedTerm
165 Nc58234cf62b84572bb09d93df717b75f schema:name readcube_id
166 schema:value c9589a76239ebeab93305182f0a5ccc8472a881fe572caa7898045813595f0a2
167 rdf:type schema:PropertyValue
168 Nd0b55b47bbfd4ce184db3b9a88af48fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Adaptor Proteins, Signal Transducing
170 rdf:type schema:DefinedTerm
171 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
172 schema:name Biological Sciences
173 rdf:type schema:DefinedTerm
174 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
175 schema:name Biochemistry and Cell Biology
176 rdf:type schema:DefinedTerm
177 sg:journal.1118362 schema:issn 1097-6256
178 1546-1726
179 schema:name Nature Neuroscience
180 rdf:type schema:Periodical
181 sg:person.01104631153.09 schema:affiliation https://www.grid.ac/institutes/grid.429510.b
182 schema:familyName Essmann
183 schema:givenName Clara L
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104631153.09
185 rdf:type schema:Person
186 sg:person.01105406047.44 schema:affiliation https://www.grid.ac/institutes/grid.429510.b
187 schema:familyName Weinges
188 schema:givenName Stefan
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105406047.44
190 rdf:type schema:Person
191 sg:person.01335633713.09 schema:affiliation https://www.grid.ac/institutes/grid.429510.b
192 schema:familyName Acker-Palmer
193 schema:givenName Amparo
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335633713.09
195 rdf:type schema:Person
196 sg:person.0771157447.01 schema:affiliation https://www.grid.ac/institutes/grid.429510.b
197 schema:familyName Segura
198 schema:givenName Inmaculada
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771157447.01
200 rdf:type schema:Person
201 sg:pub.10.1038/35093123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016114423
202 https://doi.org/10.1038/35093123
203 rdf:type schema:CreativeWork
204 sg:pub.10.1038/89460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010430249
205 https://doi.org/10.1038/89460
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/nature01273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050119611
208 https://doi.org/10.1038/nature01273
209 rdf:type schema:CreativeWork
210 sg:pub.10.1038/ncb1045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041018583
211 https://doi.org/10.1038/ncb1045
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/nn1164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051258574
214 https://doi.org/10.1038/nn1164
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/nn1487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053258316
217 https://doi.org/10.1038/nn1487
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/nn964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032251157
220 https://doi.org/10.1038/nn964
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/nn994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037079838
223 https://doi.org/10.1038/nn994
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/0092-8674(93)90404-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1048620882
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/0896-6273(92)90245-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048967754
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0092-8674(00)00197-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044793043
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/s0896-6273(01)00440-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046368936
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/s0896-6273(01)00550-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030069210
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/s0896-6273(01)00553-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036992935
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/s0896-6273(02)01168-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052312721
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/s1097-2765(02)00488-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040536139
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1046/j.1432-1033.2003.03428.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025052726
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1073/pnas.96.23.13438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052331357
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1074/jbc.273.3.1303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051210034
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1074/jbc.274.9.5542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023676759
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1074/jbc.m307317200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026594183
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1074/jbc.m511756200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028709307
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1083/jcb.144.3.575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025546421
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1083/jcb.200211002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050377448
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1083/jcb.200306033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013138593
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1091/mbc.e05-02-0131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046630906
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1101/gad.12.5.667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033186233
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1126/science.1069081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062445879
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1128/mcb.20.17.6354-6363.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032566018
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1146/annurev.neuro.24.1.1071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027559872
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1146/annurev.physiol.64.081501.160008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008031532
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1523/jneurosci.3553-04.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015330407
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1523/jneurosci.4338-05.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028081486
274 rdf:type schema:CreativeWork
275 https://www.grid.ac/institutes/grid.429510.b schema:alternateName Max Planck Institute of Neurobiology
276 schema:name Max-Planck Institute of Neurobiology, Am Klopferspitz 18, D-82152 Martinsried, Germany.
277 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...