Agouti-related peptide–expressing neurons are mandatory for feeding View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-10

AUTHORS

Eva Gropp, Marya Shanabrough, Erzsebet Borok, Allison W Xu, Ruth Janoschek, Thorsten Buch, Leona Plum, Nina Balthasar, Brigitte Hampel, Ari Waisman, Gregory S Barsh, Tamas L Horvath, Jens C Brüning

ABSTRACT

Multiple hormones controlling energy homeostasis regulate the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP) in the arcuate nucleus of the hypothalamus. Nevertheless, inactivation of the genes encoding NPY and/or AgRP has no impact on food intake in mice. Here we demonstrate that induced selective ablation of AgRP-expressing neurons in adult mice results in acute reduction of feeding, demonstrating direct evidence for a critical role of these neurons in the regulation of energy homeostasis. More... »

PAGES

1289-1291

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn1548

DOI

http://dx.doi.org/10.1038/nn1548

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053682098

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16158063


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