Notch signaling in the mammalian central nervous system: insights from mouse mutants View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-05-25

AUTHORS

Keejung Yoon, Nicholas Gaiano

ABSTRACT

The Notch pathway, although originally identified in fruit flies, is now among the most heavily studied in mammalian biology. In mice, loss-of-function and gain-of-function work has demonstrated that Notch signaling is essential both during development and in the adult in a multitude of tissues. Prominent among these is the CNS, where Notch has been implicated in processes ranging from neural stem cell regulation to learning and memory. Here we review the role of Notch in the mammalian CNS by focusing specifically on mutations generated in mice. These mutations have provided critical insight into Notch function in the CNS and have led to the identification of promising new directions that are likely to generate important discoveries in the future. More... »

PAGES

709-715

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nn1475

DOI

http://dx.doi.org/10.1038/nn1475

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006282544

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15917835


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